ID   KU_COXBR                Reviewed;         274 AA.
AC   A9NBB7;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Non-homologous end joining protein Ku {ECO:0000255|HAMAP-Rule:MF_01875};
GN   Name=ku {ECO:0000255|HAMAP-Rule:MF_01875};
GN   OrderedLocusNames=COXBURSA331_A2134;
OS   Coxiella burnetii (strain RSA 331 / Henzerling II).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales; Coxiellaceae;
OC   Coxiella.
OX   NCBI_TaxID=360115;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RSA 331 / Henzerling II;
RA   Seshadri R., Samuel J.E.;
RT   "Genome sequencing of phylogenetically and phenotypically diverse Coxiella
RT   burnetii isolates.";
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: With LigD forms a non-homologous end joining (NHEJ) DNA
CC       repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds
CC       linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA
CC       nor ssDNA. Recruits and stimulates the ligase activity of LigD.
CC       {ECO:0000255|HAMAP-Rule:MF_01875}.
CC   -!- SUBUNIT: Homodimer. Interacts with LigD. {ECO:0000255|HAMAP-
CC       Rule:MF_01875}.
CC   -!- SIMILARITY: Belongs to the prokaryotic Ku family. {ECO:0000255|HAMAP-
CC       Rule:MF_01875}.
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DR   EMBL; CP000890; ABX77812.1; -; Genomic_DNA.
DR   RefSeq; WP_012220863.1; NC_010117.1.
DR   AlphaFoldDB; A9NBB7; -.
DR   SMR; A9NBB7; -.
DR   KEGG; cbs:COXBURSA331_A2134; -.
DR   HOGENOM; CLU_048975_2_0_6; -.
DR   OMA; IRYRKVC; -.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:UniProtKB-UniRule.
DR   CDD; cd00789; KU_like; 1.
DR   Gene3D; 2.40.290.10; -; 1.
DR   HAMAP; MF_01875; Prokaryotic_Ku; 1.
DR   InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR   InterPro; IPR009187; Prok_Ku.
DR   InterPro; IPR016194; SPOC-like_C_dom_sf.
DR   PANTHER; PTHR41251; PTHR41251; 1.
DR   Pfam; PF02735; Ku; 1.
DR   PIRSF; PIRSF006493; Prok_Ku; 1.
DR   SMART; SM00559; Ku78; 1.
DR   SUPFAM; SSF100939; SSF100939; 1.
DR   TIGRFAMs; TIGR02772; Ku_bact; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA recombination; DNA repair; DNA-binding.
FT   CHAIN           1..274
FT                   /note="Non-homologous end joining protein Ku"
FT                   /id="PRO_0000389181"
FT   DOMAIN          11..195
FT                   /note="Ku"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01875"
SQ   SEQUENCE   274 AA;  31744 MW;  E47BD2A47957DB3C CRC64;
     MAARPLWKGQ ITFGLVNVPV SLYPAVGKTE IHFHLLDSRN MARVRYERVN EETGEEVPWN
     EIVKAYEYNG GDYVIVEEKE LKKAAPESTQ SIEIESFIPR RELDCVYFDK PYYLVPVKNG
     EKGYVILREV LKKTKTVGIA RIVIRSKQYL AAVFPYQKGI MVNLLRFAQE FRKTDELNLP
     TQDIKKYKIT PKELSIAEQL VNAMLTQWKP EKYHDEFRAK IMKWVEAKIK TGKTISIEKE
     EAAPVSTNVV DFMQLLKKSI QEKEKTKKHA SGSR