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KU_PARP8
ID   KU_PARP8                Reviewed;         307 AA.
AC   B2JMF6;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Non-homologous end joining protein Ku {ECO:0000255|HAMAP-Rule:MF_01875};
GN   Name=ku {ECO:0000255|HAMAP-Rule:MF_01875}; OrderedLocusNames=Bphy_5208;
OS   Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 /
OS   STM815) (Burkholderia phymatum).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=391038;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17167 / CIP 108236 / LMG 21445 / STM815;
RX   PubMed=25197461; DOI=10.4056/sigs.4861021;
RA   Moulin L., Klonowska A., Caroline B., Booth K., Vriezen J.A., Melkonian R.,
RA   James E.K., Young J.P., Bena G., Hauser L., Land M., Kyrpides N., Bruce D.,
RA   Chain P., Copeland A., Pitluck S., Woyke T., Lizotte-Waniewski M.,
RA   Bristow J., Riley M.;
RT   "Complete genome sequence of Burkholderia phymatum STM815(T), a broad host
RT   range and efficient nitrogen-fixing symbiont of Mimosa species.";
RL   Stand. Genomic Sci. 9:763-774(2014).
CC   -!- FUNCTION: With LigD forms a non-homologous end joining (NHEJ) DNA
CC       repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds
CC       linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA
CC       nor ssDNA. Recruits and stimulates the ligase activity of LigD.
CC       {ECO:0000255|HAMAP-Rule:MF_01875}.
CC   -!- SUBUNIT: Homodimer. Interacts with LigD. {ECO:0000255|HAMAP-
CC       Rule:MF_01875}.
CC   -!- SIMILARITY: Belongs to the prokaryotic Ku family. {ECO:0000255|HAMAP-
CC       Rule:MF_01875}.
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DR   EMBL; CP001044; ACC74291.1; -; Genomic_DNA.
DR   RefSeq; WP_012404455.1; NZ_CADFGH010000008.1.
DR   AlphaFoldDB; B2JMF6; -.
DR   SMR; B2JMF6; -.
DR   STRING; 391038.Bphy_5208; -.
DR   PRIDE; B2JMF6; -.
DR   EnsemblBacteria; ACC74291; ACC74291; Bphy_5208.
DR   KEGG; bph:Bphy_5208; -.
DR   eggNOG; COG1273; Bacteria.
DR   HOGENOM; CLU_048975_0_1_4; -.
DR   OMA; HAMRWPD; -.
DR   OrthoDB; 1724780at2; -.
DR   Proteomes; UP000001192; Chromosome 2.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.40.290.10; -; 1.
DR   HAMAP; MF_01875; Prokaryotic_Ku; 1.
DR   InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR   InterPro; IPR009187; Prok_Ku.
DR   InterPro; IPR016194; SPOC-like_C_dom_sf.
DR   PANTHER; PTHR41251; PTHR41251; 1.
DR   Pfam; PF02735; Ku; 1.
DR   PIRSF; PIRSF006493; Prok_Ku; 1.
DR   SMART; SM00559; Ku78; 1.
DR   SUPFAM; SSF100939; SSF100939; 1.
DR   TIGRFAMs; TIGR02772; Ku_bact; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA recombination; DNA repair; DNA-binding; Reference proteome.
FT   CHAIN           1..307
FT                   /note="Non-homologous end joining protein Ku"
FT                   /id="PRO_0000389179"
FT   DOMAIN          11..179
FT                   /note="Ku"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01875"
FT   REGION          257..307
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   307 AA;  33563 MW;  359F8FBFF3C81DC2 CRC64;
     MAARSIASLS LSFGLVSIPV KLYSATESSS DVRFNLLAPD GSRVRQQYIS ESSGAVVERS
     SMKKGYEFEK DRFVVFTADE LKALEESASH VVEIVAFIPE KSIDPVYYDK AYYIAPDRRG
     GKPYSLLQQA LAESGRCALA KWASKGKTRI VQVRPSADGL VFQQLLFADE VRSMKDLNIE
     HVDVSASELK LAMQIIEQGT EDHYDPAAYE DEEKKRILAA IDRKIEGKQV ISNERADVPA
     EGGEVIDLME ALRASLRGGA KAKPAAAPRR KAPEPVAGMA EATRARKPAA RAPKSPAEAP
     AKVRARK
 
 
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