KU_SOLUE
ID KU_SOLUE Reviewed; 267 AA.
AC Q021H8;
DT 24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 14-NOV-2006, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Non-homologous end joining protein Ku {ECO:0000255|HAMAP-Rule:MF_01875};
GN Name=ku {ECO:0000255|HAMAP-Rule:MF_01875}; OrderedLocusNames=Acid_3438;
OS Solibacter usitatus (strain Ellin6076).
OC Bacteria; Acidobacteria; Bryobacterales; Solibacteraceae;
OC Candidatus Solibacter.
OX NCBI_TaxID=234267;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ellin6076;
RX PubMed=19201974; DOI=10.1128/aem.02294-08;
RA Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M.,
RA Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B.,
RA Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C.,
RA Davidsen T.M., DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S.,
RA Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P.,
RA Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q.,
RA Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R.,
RA Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R.;
RT "Three genomes from the phylum Acidobacteria provide insight into the
RT lifestyles of these microorganisms in soils.";
RL Appl. Environ. Microbiol. 75:2046-2056(2009).
CC -!- FUNCTION: With LigD forms a non-homologous end joining (NHEJ) DNA
CC repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds
CC linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA
CC nor ssDNA. Recruits and stimulates the ligase activity of LigD.
CC {ECO:0000255|HAMAP-Rule:MF_01875}.
CC -!- SUBUNIT: Homodimer. Interacts with LigD. {ECO:0000255|HAMAP-
CC Rule:MF_01875}.
CC -!- SIMILARITY: Belongs to the prokaryotic Ku family. {ECO:0000255|HAMAP-
CC Rule:MF_01875}.
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DR EMBL; CP000473; ABJ84411.1; -; Genomic_DNA.
DR RefSeq; WP_011685172.1; NC_008536.1.
DR AlphaFoldDB; Q021H8; -.
DR STRING; 234267.Acid_3438; -.
DR EnsemblBacteria; ABJ84411; ABJ84411; Acid_3438.
DR KEGG; sus:Acid_3438; -.
DR eggNOG; COG1273; Bacteria.
DR HOGENOM; CLU_048975_1_0_0; -.
DR OMA; HAMRWPD; -.
DR OrthoDB; 1724780at2; -.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:UniProtKB-UniRule.
DR CDD; cd00789; KU_like; 1.
DR Gene3D; 2.40.290.10; -; 1.
DR HAMAP; MF_01875; Prokaryotic_Ku; 1.
DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR InterPro; IPR009187; Prok_Ku.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR PANTHER; PTHR41251; PTHR41251; 1.
DR Pfam; PF02735; Ku; 1.
DR PIRSF; PIRSF006493; Prok_Ku; 1.
DR SMART; SM00559; Ku78; 1.
DR SUPFAM; SSF100939; SSF100939; 1.
DR TIGRFAMs; TIGR02772; Ku_bact; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA recombination; DNA repair; DNA-binding.
FT CHAIN 1..267
FT /note="Non-homologous end joining protein Ku"
FT /id="PRO_0000389198"
FT DOMAIN 10..190
FT /note="Ku"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01875"
SQ SEQUENCE 267 AA; 30236 MW; 20BD29ABB322797F CRC64;
MAAIVWKGFI SFGLVSFPVR LNAAARPETI HFHMLHKKDE SRVKEVWYCA DENKPIDRAE
IVKGYEVRKG EYVVIEDEDL KKIAPPTATT MDILQFVKSD QVDPIYFESS YYVGAEEGGG
KAYALFVAAL DATKEDAIAK LSMHNREHIV LIRASDNALV LHTLYYPNEL HKANRSETPK
TKYTAKELEL AQSLVSQLTA PFKPQEFHDE YRENVEHLIE QKRKGGKITA VKQPRKAPVI
DLMEALKRSV KAAESKRKKP AGKRKAA