ID   KU_STRGG                Reviewed;         395 AA.
AC   B1W0D5;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Non-homologous end joining protein Ku {ECO:0000255|HAMAP-Rule:MF_01875};
GN   Name=ku {ECO:0000255|HAMAP-Rule:MF_01875}; OrderedLocusNames=SGR_2195;
OS   Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=455632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 4626 / NBRC 13350;
RX   PubMed=18375553; DOI=10.1128/jb.00204-08;
RA   Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA   Yamashita A., Hattori M., Horinouchi S.;
RT   "Genome sequence of the streptomycin-producing microorganism Streptomyces
RT   griseus IFO 13350.";
RL   J. Bacteriol. 190:4050-4060(2008).
CC   -!- FUNCTION: With LigD forms a non-homologous end joining (NHEJ) DNA
CC       repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds
CC       linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA
CC       nor ssDNA. Recruits and stimulates the ligase activity of LigD.
CC       {ECO:0000255|HAMAP-Rule:MF_01875}.
CC   -!- SUBUNIT: Homodimer. Interacts with LigD. {ECO:0000255|HAMAP-
CC       Rule:MF_01875}.
CC   -!- SIMILARITY: Belongs to the prokaryotic Ku family. {ECO:0000255|HAMAP-
CC       Rule:MF_01875}.
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DR   EMBL; AP009493; BAG19024.1; -; Genomic_DNA.
DR   RefSeq; WP_012379039.1; NC_010572.1.
DR   AlphaFoldDB; B1W0D5; -.
DR   STRING; 455632.SGR_2195; -.
DR   EnsemblBacteria; BAG19024; BAG19024; SGR_2195.
DR   GeneID; 6212891; -.
DR   KEGG; sgr:SGR_2195; -.
DR   PATRIC; fig|455632.4.peg.2232; -.
DR   eggNOG; COG1273; Bacteria.
DR   HOGENOM; CLU_048975_1_1_11; -.
DR   OMA; IRYRKVC; -.
DR   OrthoDB; 1724780at2; -.
DR   Proteomes; UP000001685; Chromosome.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:UniProtKB-UniRule.
DR   CDD; cd00789; KU_like; 1.
DR   Gene3D; 2.40.290.10; -; 1.
DR   HAMAP; MF_01875; Prokaryotic_Ku; 1.
DR   InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR   InterPro; IPR009187; Prok_Ku.
DR   InterPro; IPR016194; SPOC-like_C_dom_sf.
DR   PANTHER; PTHR41251; PTHR41251; 1.
DR   Pfam; PF02735; Ku; 1.
DR   SMART; SM00559; Ku78; 1.
DR   SUPFAM; SSF100939; SSF100939; 1.
DR   TIGRFAMs; TIGR02772; Ku_bact; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA recombination; DNA repair; DNA-binding.
FT   CHAIN           1..395
FT                   /note="Non-homologous end joining protein Ku"
FT                   /id="PRO_0000389200"
FT   DOMAIN          9..181
FT                   /note="Ku"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01875"
FT   REGION          252..395
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        253..267
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        282..298
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        307..395
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   395 AA;  41672 MW;  E6D3DC5D001322ED CRC64;
     MRSIWNGAIS FGLVSIPIKL VNATENHSIS FRQIHLADGG RIRYRKVCEL DEQEVSGSET
     GKAYEDADGT MIPITDEDLA QLPLPTAKTI EIVAFVPADR IDPLQMDAAY YLSANGVPAA
     KPYTLLREAL KRSNRVAVAK YALRGRERLG MLRVVGEVIA LHGLLWPDEI RPPEDAAPDG
     DITVRDAELD LADTLMSTLG EVDMDSLHDD YREAVEELAA AKASGESVPP AEPEDTGGEV
     IDLIAALENS VRAARTSRDD EGAGGDGGDM ADVHPIGRGA KASSKTSGQS SGKAARTTKT
     ARRTTHRTPT GKTVTRSGDS TAEKSAPKSS GAKKSTAKKS TAKKTAAQKT TARKTTAKKT
     TAKGTTGTTA AAKKRTSSGG GTAKKSASSR KRTSA