ID   KU_SYMTH                Reviewed;         402 AA.
AC   Q67NG0;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Non-homologous end joining protein Ku {ECO:0000255|HAMAP-Rule:MF_01875};
GN   Name=ku {ECO:0000255|HAMAP-Rule:MF_01875}; OrderedLocusNames=STH1798;
OS   Symbiobacterium thermophilum (strain T / IAM 14863).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Symbiobacteriaceae;
OC   Symbiobacterium.
OX   NCBI_TaxID=292459;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T / IAM 14863;
RX   PubMed=15383646; DOI=10.1093/nar/gkh830;
RA   Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K.,
RA   Ikeda H., Hattori M., Beppu T.;
RT   "Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium
RT   that depends on microbial commensalism.";
RL   Nucleic Acids Res. 32:4937-4944(2004).
CC   -!- FUNCTION: With LigD forms a non-homologous end joining (NHEJ) DNA
CC       repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds
CC       linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA
CC       nor ssDNA. Recruits and stimulates the ligase activity of LigD.
CC       {ECO:0000255|HAMAP-Rule:MF_01875}.
CC   -!- SUBUNIT: Homodimer. Interacts with LigD. {ECO:0000255|HAMAP-
CC       Rule:MF_01875}.
CC   -!- SIMILARITY: Belongs to the prokaryotic Ku family. {ECO:0000255|HAMAP-
CC       Rule:MF_01875}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP006840; BAD40783.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q67NG0; -.
DR   STRING; 292459.STH1798; -.
DR   EnsemblBacteria; BAD40783; BAD40783; STH1798.
DR   KEGG; sth:STH1798; -.
DR   eggNOG; COG1273; Bacteria.
DR   HOGENOM; CLU_048975_2_0_9; -.
DR   OMA; IRYRKVC; -.
DR   Proteomes; UP000000417; Chromosome.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:UniProtKB-UniRule.
DR   CDD; cd00789; KU_like; 1.
DR   Gene3D; 2.40.290.10; -; 1.
DR   HAMAP; MF_01875; Prokaryotic_Ku; 1.
DR   InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR   InterPro; IPR009187; Prok_Ku.
DR   InterPro; IPR016194; SPOC-like_C_dom_sf.
DR   PANTHER; PTHR41251; PTHR41251; 1.
DR   Pfam; PF02735; Ku; 1.
DR   SMART; SM00559; Ku78; 1.
DR   SUPFAM; SSF100939; SSF100939; 1.
DR   TIGRFAMs; TIGR02772; Ku_bact; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA recombination; DNA repair; DNA-binding; Reference proteome.
FT   CHAIN           1..402
FT                   /note="Non-homologous end joining protein Ku"
FT                   /id="PRO_0000389201"
FT   DOMAIN          12..185
FT                   /note="Ku"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01875"
FT   REGION          261..402
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        305..362
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   402 AA;  41840 MW;  FBA85D71B31AA319 CRC64;
     MDALRAMWKG TISFGLVTIP VKLYAATESK DLRFNLLHEP CQTPVQYRKY CPTCEREVES
     GEIVKGYEFD RGRYVTLRDE DFESIPLAAR RTLEIVAFVR LEEIDPIYFD KTYYLEPGEG
     GAKAYGLLRH AMEVTGRVAI ARVVLRAKES LAALRVFREG VLAMETMHFP DEVRPVAALT
     GIAQPELRPQ EIEMATGLIE SLTMPFSPER FENTYREALL ELIQAKIAGA PPAEPGPAPE
     QGRVVDLMEA LRASIRAAEA QRAAGGATGG AAGADGTPPA PVARSPEAPA RRAIPGLPGD
     PAASVPGVPA APVPRAPGVT GAPTPGTPPA AVPGVPATAV PGTPGAPVPT APGVPSAPAP
     GTSPTSVPGV QTAPNGAAPP GPFAGSDRAA EVGPDETAPG GP