ID   KV10_RABIT              Reviewed;         117 AA.
AC   P01691;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Ig kappa chain V region 12F2;
DE   Flags: Precursor; Fragment;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=6410392; DOI=10.1073/pnas.80.14.4489;
RA   Dreher K.L., Emorine L., Kindt T.J., Max E.E.;
RT   "cDNA clone encoding a complete rabbit immunoglobulin kappa light chain of
RT   b4 allotype.";
RL   Proc. Natl. Acad. Sci. U.S.A. 80:4489-4493(1983).
CC   -!- MISCELLANEOUS: This clone was derived from the rabbit-mouse hybridoma
CC       12F2; the chain produced is a monoclonal antibody against streptococcal
CC       group C vaccine.
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DR   EMBL; K01358; AAB59259.1; ALT_TERM; mRNA.
DR   PIR; A01954; K4RBF2.
DR   AlphaFoldDB; P01691; -.
DR   SMR; P01691; -.
DR   STRING; 9986.ENSOCUP00000024818; -.
DR   eggNOG; ENOG502S3KF; Eukaryota.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0019814; C:immunoglobulin complex; IEA:UniProtKB-KW.
DR   GO; GO:0003823; F:antigen binding; IEA:UniProtKB-KW.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Adaptive immunity; Disulfide bond; Hybridoma; Immunity; Immunoglobulin;
KW   Monoclonal antibody; Reference proteome; Signal.
FT   SIGNAL          <1..6
FT   CHAIN           7..117
FT                   /note="Ig kappa chain V region 12F2"
FT                   /id="PRO_0000015167"
FT   REGION          7..29
FT                   /note="Framework-1"
FT   REGION          30..40
FT                   /note="Complementarity-determining-1"
FT   REGION          41..55
FT                   /note="Framework-2"
FT   REGION          56..62
FT                   /note="Complementarity-determining-2"
FT   REGION          63..94
FT                   /note="Framework-3"
FT   REGION          95..106
FT                   /note="Complementarity-determining-3"
FT   REGION          107..116
FT                   /note="Framework-4"
FT   DISULFID        29..86
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   NON_TER         1
FT   NON_TER         117
SQ   SEQUENCE   117 AA;  12288 MW;  E24A7582389E4439 CRC64;
     LPGARCAYDM TQTPASVEVA VGGTVTIKCQ ASQSISTYLS WYQQKPGQRP KLLIYRASTL
     ASGVSSRFKG SGSGTEFTLT ISGVECADAA TYYCQQGWSS SNVENVFGGG TEVVVKG