KV2A2_MOUSE
ID KV2A2_MOUSE Reviewed; 120 AA.
AC P01627;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Immunoglobulin kappa variable 2-112 {ECO:0000312|MGI:MGI:3644894};
DE AltName: Full=Ig kappa chain V-II region VKappa167 {ECO:0000305};
DE Flags: Precursor;
GN Name=Igkv2-112 {ECO:0000312|MGI:MGI:3644894};
GN Synonyms=Gm5153 {ECO:0000312|MGI:MGI:3644894};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6791832; DOI=10.1016/0092-8674(81)90230-0;
RA Selsing E., Storb U.;
RT "Somatic mutation of immunoglobulin light-chain variable-region genes.";
RL Cell 25:47-58(1981).
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DR EMBL; J00562; AAA39032.1; -; Genomic_DNA.
DR EMBL; K02415; AAA39051.1; -; Genomic_DNA.
DR PIR; A01909; KVMS67.
DR AlphaFoldDB; P01627; -.
DR SMR; P01627; -.
DR CPTAC; non-CPTAC-3470; -.
DR MaxQB; P01627; -.
DR PRIDE; P01627; -.
DR Ensembl; ENSMUST00000103318; ENSMUSP00000100119; ENSMUSG00000076518.
DR MGI; MGI:3644894; Igkv2-112.
DR VEuPathDB; HostDB:ENSMUSG00000076518; -.
DR GeneTree; ENSGT00940000153770; -.
DR HOGENOM; CLU_077975_4_1_1; -.
DR InParanoid; P01627; -.
DR OMA; GKSYLNW; -.
DR PhylomeDB; P01627; -.
DR Reactome; R-MMU-166663; Initial triggering of complement.
DR Reactome; R-MMU-173623; Classical antibody-mediated complement activation.
DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR Reactome; R-MMU-202733; Cell surface interactions at the vascular wall.
DR Reactome; R-MMU-2029481; FCGR activation.
DR Reactome; R-MMU-2029482; Regulation of actin dynamics for phagocytic cup formation.
DR Reactome; R-MMU-2029485; Role of phospholipids in phagocytosis.
DR Reactome; R-MMU-2168880; Scavenging of heme from plasma.
DR Reactome; R-MMU-2454202; Fc epsilon receptor (FCERI) signaling.
DR Reactome; R-MMU-2730905; Role of LAT2/NTAL/LAB on calcium mobilization.
DR Reactome; R-MMU-2871796; FCERI mediated MAPK activation.
DR Reactome; R-MMU-2871809; FCERI mediated Ca+2 mobilization.
DR Reactome; R-MMU-2871837; FCERI mediated NF-kB activation.
DR Reactome; R-MMU-5690714; CD22 mediated BCR regulation.
DR Reactome; R-MMU-977606; Regulation of Complement cascade.
DR Reactome; R-MMU-983695; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
DR ChiTaRS; Igkv2-112; mouse.
DR PRO; PR:P01627; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; P01627; protein.
DR Bgee; ENSMUSG00000076518; Expressed in spleen and 30 other tissues.
DR ExpressionAtlas; P01627; baseline and differential.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0019814; C:immunoglobulin complex; IEA:UniProtKB-KW.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 4: Predicted;
KW Adaptive immunity; Disulfide bond; Immunity; Immunoglobulin;
KW Reference proteome; Signal.
FT SIGNAL 1..20
FT CHAIN 21..120
FT /note="Immunoglobulin kappa variable 2-112"
FT /id="PRO_0000015185"
FT REGION 21..43
FT /note="Framework-1"
FT REGION 44..59
FT /note="Complementarity-determining-1"
FT REGION 60..74
FT /note="Framework-2"
FT REGION 75..81
FT /note="Complementarity-determining-2"
FT REGION 82..113
FT /note="Framework-3"
FT REGION 114..120
FT /note="Complementarity-determining-3"
FT DISULFID 43..113
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 120 AA; 13280 MW; 63BB571F0E4DE3E8 CRC64;
MRCSLQFLGV LMFWISGVSG DIVITQDELS NPVTSGESVS ISCRSSKSLL YKDGKTYLNW
FLQRPGQSPQ LLIYLMSTRA SGVSDRFSGS GSGTDFTLEI SRVKAEDVGV YYCQQLVEYP
