ID   KV2A6_MOUSE             Reviewed;         113 AA.
AC   P01630;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Ig kappa chain V-II region 7S34.1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=6409088; DOI=10.1042/bj2110173;
RA   Chang J.-Y., Herbst H., Aebersold R., Braun D.G.;
RT   "A new isotype sequence (V kappa 27) of the variable region of kappa-light
RT   chains from a mouse hybridoma-derived anti-(streptococcal group A
RT   polysaccharide) antibody containing an additional cysteine residue.
RT   Application of the dimethylaminoazobenzene isothiocyanate technique for the
RT   isolation of peptides.";
RL   Biochem. J. 211:173-180(1983).
CC   -!- MISCELLANEOUS: This chain is from a hybridoma-derived monoclonal
CC       antibody against the streptococcal group A polysaccharide.
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DR   PIR; A01913; KVMS7S.
DR   PDB; 5YD3; X-ray; 1.35 A; A/C/E/G=1-112.
DR   PDB; 5YD4; X-ray; 1.35 A; A/C/E/G=1-112.
DR   PDB; 5YD5; X-ray; 1.96 A; A/C=1-112.
DR   PDBsum; 5YD3; -.
DR   PDBsum; 5YD4; -.
DR   PDBsum; 5YD5; -.
DR   AlphaFoldDB; P01630; -.
DR   SMR; P01630; -.
DR   MaxQB; P01630; -.
DR   PRIDE; P01630; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P01630; protein.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0019814; C:immunoglobulin complex; IEA:UniProtKB-KW.
DR   GO; GO:0003823; F:antigen binding; IEA:UniProtKB-KW.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Adaptive immunity; Direct protein sequencing; Disulfide bond;
KW   Hybridoma; Immunity; Immunoglobulin; Monoclonal antibody;
KW   Reference proteome.
FT   CHAIN           1..>113
FT                   /note="Ig kappa chain V-II region 7S34.1"
FT                   /id="PRO_0000059775"
FT   REGION          1..23
FT                   /note="Framework-1"
FT   REGION          24..39
FT                   /note="Complementarity-determining-1"
FT   REGION          40..54
FT                   /note="Framework-2"
FT   REGION          55..61
FT                   /note="Complementarity-determining-2"
FT   REGION          62..93
FT                   /note="Framework-3"
FT   REGION          94..102
FT                   /note="Complementarity-determining-3"
FT   REGION          103..112
FT                   /note="Framework-4"
FT   DISULFID        23..93
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   NON_TER         113
FT   STRAND          9..13
FT                   /evidence="ECO:0007829|PDB:5YD3"
FT   STRAND          19..27
FT                   /evidence="ECO:0007829|PDB:5YD3"
FT   STRAND          38..43
FT                   /evidence="ECO:0007829|PDB:5YD3"
FT   STRAND          49..54
FT                   /evidence="ECO:0007829|PDB:5YD3"
FT   TURN            55..57
FT                   /evidence="ECO:0007829|PDB:5YD3"
FT   STRAND          67..71
FT                   /evidence="ECO:0007829|PDB:5YD3"
FT   STRAND          73..80
FT                   /evidence="ECO:0007829|PDB:5YD3"
FT   HELIX           85..87
FT                   /evidence="ECO:0007829|PDB:5YD3"
FT   STRAND          89..95
FT                   /evidence="ECO:0007829|PDB:5YD3"
FT   STRAND          97..100
FT                   /evidence="ECO:0007829|PDB:5YD3"
FT   STRAND          107..111
FT                   /evidence="ECO:0007829|PDB:5YD3"
SQ   SEQUENCE   113 AA;  12496 MW;  42C019D10ADA3C91 CRC64;
     DIVMTQTAPS ALVTPGESVS ISCRSSKSLL HSNGNTYLYW FLQRPGQCPQ LLIYRMSNLA
     SGVPDRFSGS GSGTAFTLRI SRVEAEDVGV YYCMQQREYP YTFGGGTKLE IKR