KV2A7_MOUSE
ID KV2A7_MOUSE Reviewed; 113 AA.
AC P01631;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 25-MAY-2022, entry version 122.
DE RecName: Full=Ig kappa chain V-II region 26-10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP PROTEIN SEQUENCE.
RC STRAIN=A/J;
RX PubMed=6404298; DOI=10.1021/bi00274a025;
RA Novotny J., Margolies M.N.;
RT "Amino acid sequence of the light chain variable region from a mouse anti-
RT digoxin hybridoma antibody.";
RL Biochemistry 22:1153-1158(1983).
CC -!- MISCELLANEOUS: This chain was isolated from an IgG2a hybridoma protein
CC that binds digoxin.
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DR PIR; A01914; KVMS26.
DR PIR; A32248; A32248.
DR PIR; B32248; B32248.
DR PIR; C32248; C32248.
DR PIR; F32530; F32530.
DR PIR; H31485; H31485.
DR PIR; PH1030; PH1030.
DR PIR; PH1031; PH1031.
DR PIR; S53750; S53750.
DR PDB; 1BFV; X-ray; 2.10 A; L=5-113.
DR PDB; 1CFV; X-ray; 2.10 A; L=5-113.
DR PDB; 1DLF; X-ray; 1.45 A; L=1-113.
DR PDB; 1MAJ; NMR; -; A=1-113.
DR PDB; 1MAK; NMR; -; A=1-113.
DR PDB; 1N4X; X-ray; 1.70 A; L/M=4-110.
DR PDB; 1SVZ; X-ray; 1.89 A; A/B=1-112.
DR PDB; 1WZ1; X-ray; 1.85 A; L=1-113.
DR PDB; 2BFV; X-ray; 2.50 A; L=5-113.
DR PDB; 2DLF; X-ray; 1.55 A; L=1-113.
DR PDB; 2HKF; X-ray; 2.01 A; L=1-113.
DR PDB; 2HKH; X-ray; 2.10 A; L=1-113.
DR PDB; 2IPT; X-ray; 2.00 A; L=1-113.
DR PDB; 2IQA; X-ray; 2.00 A; A/L=1-113.
DR PDB; 2O5X; X-ray; 2.05 A; L=1-113.
DR PDB; 2O5Y; X-ray; 2.85 A; L=1-113.
DR PDB; 2O5Z; X-ray; 2.40 A; L=1-113.
DR PDB; 2R0W; X-ray; 2.50 A; L=1-113.
DR PDB; 2VQ1; X-ray; 2.50 A; A/E=1-113.
DR PDBsum; 1BFV; -.
DR PDBsum; 1CFV; -.
DR PDBsum; 1DLF; -.
DR PDBsum; 1MAJ; -.
DR PDBsum; 1MAK; -.
DR PDBsum; 1N4X; -.
DR PDBsum; 1SVZ; -.
DR PDBsum; 1WZ1; -.
DR PDBsum; 2BFV; -.
DR PDBsum; 2DLF; -.
DR PDBsum; 2HKF; -.
DR PDBsum; 2HKH; -.
DR PDBsum; 2IPT; -.
DR PDBsum; 2IQA; -.
DR PDBsum; 2O5X; -.
DR PDBsum; 2O5Y; -.
DR PDBsum; 2O5Z; -.
DR PDBsum; 2R0W; -.
DR PDBsum; 2VQ1; -.
DR AlphaFoldDB; P01631; -.
DR SMR; P01631; -.
DR IntAct; P01631; 1.
DR MINT; P01631; -.
DR CPTAC; non-CPTAC-3718; -.
DR EPD; P01631; -.
DR MaxQB; P01631; -.
DR PeptideAtlas; P01631; -.
DR PRIDE; P01631; -.
DR EvolutionaryTrace; P01631; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P01631; protein.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0019814; C:immunoglobulin complex; IEA:UniProtKB-KW.
DR GO; GO:0003823; F:antigen binding; IEA:UniProtKB-KW.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Adaptive immunity; Direct protein sequencing; Disulfide bond;
KW Hybridoma; Immunity; Immunoglobulin; Monoclonal antibody;
KW Reference proteome.
FT CHAIN 1..>113
FT /note="Ig kappa chain V-II region 26-10"
FT /id="PRO_0000059776"
FT REGION 1..23
FT /note="Framework-1"
FT REGION 24..39
FT /note="Complementarity-determining-1"
FT REGION 40..54
FT /note="Framework-2"
FT REGION 55..61
FT /note="Complementarity-determining-2"
FT REGION 62..93
FT /note="Framework-3"
FT REGION 94..102
FT /note="Complementarity-determining-3"
FT REGION 103..112
FT /note="Framework-4"
FT DISULFID 23..93
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT NON_TER 113
FT STRAND 4..7
FT /evidence="ECO:0007829|PDB:1DLF"
FT STRAND 9..13
FT /evidence="ECO:0007829|PDB:1DLF"
FT STRAND 19..27
FT /evidence="ECO:0007829|PDB:1DLF"
FT STRAND 31..34
FT /evidence="ECO:0007829|PDB:1BFV"
FT STRAND 38..43
FT /evidence="ECO:0007829|PDB:1DLF"
FT STRAND 50..54
FT /evidence="ECO:0007829|PDB:1DLF"
FT TURN 55..57
FT /evidence="ECO:0007829|PDB:1DLF"
FT STRAND 67..72
FT /evidence="ECO:0007829|PDB:1DLF"
FT STRAND 75..80
FT /evidence="ECO:0007829|PDB:1DLF"
FT HELIX 85..87
FT /evidence="ECO:0007829|PDB:1DLF"
FT STRAND 89..95
FT /evidence="ECO:0007829|PDB:1DLF"
FT STRAND 97..100
FT /evidence="ECO:0007829|PDB:1DLF"
FT STRAND 107..111
FT /evidence="ECO:0007829|PDB:1DLF"
SQ SEQUENCE 113 AA; 12273 MW; F9F39CE949A84C2A CRC64;
DVVMTQTPLS LPVSLGDQAS ISCRSSQSLV HSNGNTYLNW YLQKAGQSPK LLIYKVSNRF
SGVPDRFSGS GSGTDFTLKI SRVEAEDLGI YFCSQTTHVP PTFGGGTKLE IKR
