ID   KV3A6_MOUSE             Reviewed;         132 AA.
AC   P01658;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   23-FEB-2022, entry version 94.
DE   RecName: Full=Ig kappa chain V-III region MOPC 321;
DE   Flags: Precursor;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   PROTEIN SEQUENCE OF 1-37 (PRECURSOR PROTEIN).
RX   PubMed=98179; DOI=10.1021/bi00605a022;
RA   Burstein Y., Schechter I.;
RT   "Primary structures of N-terminal extra peptide segments linked to the
RT   variable and constant regions of immunoglobulin light chain precursors:
RT   implications on the organization and controlled expression of
RT   immunoglobulin genes.";
RL   Biochemistry 17:2392-2400(1978).
RN   [2]
RP   PROTEIN SEQUENCE OF 21-132.
RX   PubMed=4120629; DOI=10.1021/bi00728a027;
RA   McKean D.J., Potter M., Hood L.E.;
RT   "Mouse immunoglobulin chains. Partial amino acid sequence of a kappa
RT   chain.";
RL   Biochemistry 12:749-759(1973).
CC   -!- MISCELLANEOUS: The partial sequence of the C region of this Bence-Jones
CC       protein was also determined. It differs from that reported for mouse
CC       MOPC 21 only in the transposition of two nearby residues.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; A90412; KVMS32.
DR   MaxQB; P01658; -.
DR   PRIDE; P01658; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P01658; protein.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0019814; C:immunoglobulin complex; IEA:UniProtKB-KW.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   Adaptive immunity; Bence-Jones protein; Direct protein sequencing;
KW   Disulfide bond; Immunity; Immunoglobulin; Reference proteome; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000269|PubMed:4120629"
FT   CHAIN           21..132
FT                   /note="Ig kappa chain V-III region MOPC 321"
FT                   /id="PRO_0000015186"
FT   REGION          21..43
FT                   /note="Framework-1"
FT   REGION          44..58
FT                   /note="Complementarity-determining-1"
FT   REGION          59..73
FT                   /note="Framework-2"
FT   REGION          74..80
FT                   /note="Complementarity-determining-2"
FT   REGION          81..112
FT                   /note="Framework-3"
FT   REGION          113..121
FT                   /note="Complementarity-determining-3"
FT   REGION          122..131
FT                   /note="Framework-4"
FT   DISULFID        43..112
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   NON_TER         132
SQ   SEQUENCE   132 AA;  14525 MW;  9F3B809BB773FBE9 CRC64;
     METDTLLLWV LLLWVPGSTG DIVLTQSPAS LAVSLGQRAT ISCRASKSVN TYGNSFMZWY
     ZZKPGZPPKL LIYRASNLZS GIPARFSGSG SRTBFTLTIB PVZABDVATY FCZZSBZBPW
     TFGSGTKLEI KR