ID   KV3A9_MOUSE             Reviewed;         131 AA.
AC   P01661;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 116.
DE   RecName: Full=Ig kappa chain V-III region MOPC 63;
DE   Flags: Precursor;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   PROTEIN SEQUENCE OF 1-35 (PRECURSOR PROTEIN).
RX   PubMed=98179; DOI=10.1021/bi00605a022;
RA   Burstein Y., Schechter I.;
RT   "Primary structures of N-terminal extra peptide segments linked to the
RT   variable and constant regions of immunoglobulin light chain precursors:
RT   implications on the organization and controlled expression of
RT   immunoglobulin genes.";
RL   Biochemistry 17:2392-2400(1978).
RN   [2]
RP   PROTEIN SEQUENCE OF 21-131.
RX   PubMed=4691517; DOI=10.1021/bi00728a028;
RA   McKean D.J., Potter M., Hood L.E.;
RT   "Mouse immunoglobulin chains. Pattern of sequence variation among kappa
RT   chains with limited sequence differences.";
RL   Biochemistry 12:760-771(1973).
RN   [3]
RP   SEQUENCE REVISION.
RX   PubMed=99744; DOI=10.1073/pnas.75.8.3913;
RA   McKean D.J., Bell M., Potter M.;
RT   "Mechanisms of antibody diversity: multiple genes encode structurally
RT   related mouse kappa variable regions.";
RL   Proc. Natl. Acad. Sci. U.S.A. 75:3913-3917(1978).
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DR   PIR; B90412; KVMSM6.
DR   PIR; D45722; D45722.
DR   PDB; 1EGJ; X-ray; 2.80 A; L=21-131.
DR   PDBsum; 1EGJ; -.
DR   AlphaFoldDB; P01661; -.
DR   SMR; P01661; -.
DR   MaxQB; P01661; -.
DR   PeptideAtlas; P01661; -.
DR   PRIDE; P01661; -.
DR   PhylomeDB; P01661; -.
DR   EvolutionaryTrace; P01661; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P01661; protein.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0019814; C:immunoglobulin complex; IEA:UniProtKB-KW.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Adaptive immunity; Direct protein sequencing; Disulfide bond;
KW   Immunity; Immunoglobulin; Reference proteome; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000269|PubMed:4691517"
FT   CHAIN           21..131
FT                   /note="Ig kappa chain V-III region MOPC 63"
FT                   /id="PRO_0000015187"
FT   REGION          21..43
FT                   /note="Framework-1"
FT   REGION          44..58
FT                   /note="Complementarity-determining-1"
FT   REGION          59..73
FT                   /note="Framework-2"
FT   REGION          74..80
FT                   /note="Complementarity-determining-2"
FT   REGION          81..112
FT                   /note="Framework-3"
FT   REGION          113..121
FT                   /note="Complementarity-determining-3"
FT   REGION          122..131
FT                   /note="Framework-4"
FT   DISULFID        43..112
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   NON_TER         131
FT   STRAND          24..27
FT                   /evidence="ECO:0007829|PDB:1EGJ"
FT   STRAND          29..31
FT                   /evidence="ECO:0007829|PDB:1EGJ"
FT   STRAND          39..47
FT                   /evidence="ECO:0007829|PDB:1EGJ"
FT   STRAND          57..62
FT                   /evidence="ECO:0007829|PDB:1EGJ"
FT   STRAND          68..73
FT                   /evidence="ECO:0007829|PDB:1EGJ"
FT   TURN            74..76
FT                   /evidence="ECO:0007829|PDB:1EGJ"
FT   STRAND          86..90
FT                   /evidence="ECO:0007829|PDB:1EGJ"
FT   STRAND          92..101
FT                   /evidence="ECO:0007829|PDB:1EGJ"
FT   STRAND          108..114
FT                   /evidence="ECO:0007829|PDB:1EGJ"
FT   STRAND          116..119
FT                   /evidence="ECO:0007829|PDB:1EGJ"
FT   STRAND          126..128
FT                   /evidence="ECO:0007829|PDB:1EGJ"
SQ   SEQUENCE   131 AA;  14291 MW;  D212EC9F08DC880A CRC64;
     METDTLLLWV LLLWVPGSTG NIVLTQSPAS LAVSLGQRAT ISCRASESVD SYGNSFMHWY
     QQKPGQPPKL LIYLASNLES GVPARFSGSG SRTDFTLTID PVEADDAATY YCQQNNEDPW
     TFGGGTKLEI K