ID   KV51_METSE              Reviewed;          90 AA.
AC   P0DMD7;
DT   19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
DT   19-MAR-2014, sequence version 1.
DT   23-FEB-2022, entry version 12.
DE   RecName: Full=U-metritoxin-Msn2a {ECO:0000305};
DE            Short=U-MTTX-Msn2a {ECO:0000305};
DE   AltName: Full=Toxin MsePTx1 {ECO:0000303|PubMed:23895459};
DE   Flags: Precursor;
OS   Metridium senile (Brown sea anemone) (Frilled sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Nynantheae; Metridiidae; Metridium.
OX   NCBI_TaxID=6116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Richardson P., Lucas S., Rokhsar D., Wang M., Lindquist E.A.;
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=23895459; DOI=10.1111/febs.12456;
RA   Orts D.J., Moran Y., Cologna C.T., Peigneur S., Madio B., Praher D.,
RA   Quinton L., De Pauw E., Bicudo J.E., Tytgat J., de Freitas J.C.;
RT   "BcsTx3 is a founder of a novel sea anemone toxin family of potassium
RT   channel blocker.";
RL   FEBS J. 280:4839-4852(2013).
CC   -!- FUNCTION: Neurotoxin (By similarity). Blocks voltage-gated potassium
CC       channel (Kv) (By similarity). In vivo, induces a rapid increase in
CC       swimming speed on zebrafish larvae, as well as death which occurs
CC       between 2 and 18 hours later (By similarity).
CC       {ECO:0000250|UniProtKB:A7RMN1, ECO:0000250|UniProtKB:C0HJC4}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:C0HJC4}.
CC       Nematocyst {ECO:0000250|UniProtKB:C0HJC4}.
CC   -!- PTM: Contains 4 disulfide bonds. {ECO:0000250|UniProtKB:C0HJC4}.
CC   -!- SIMILARITY: Belongs to the sea anemone type 5 potassium channel toxin
CC       family. {ECO:0000305}.
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DR   EMBL; FC839755; -; NOT_ANNOTATED_CDS; mRNA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond;
KW   Ion channel impairing toxin; Nematocyst; Neurotoxin;
KW   Potassium channel impairing toxin; Secreted; Signal; Toxin;
KW   Voltage-gated potassium channel impairing toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..27
FT                   /evidence="ECO:0000305|PubMed:23895459"
FT                   /id="PRO_0000425830"
FT   CHAIN           28..76
FT                   /note="U-metritoxin-Msn2a"
FT                   /evidence="ECO:0000250|UniProtKB:C0HJC4,
FT                   ECO:0000305|PubMed:23895459"
FT                   /id="PRO_0000425831"
FT   PROPEP          77..90
FT                   /evidence="ECO:0000305|PubMed:23895459"
FT                   /id="PRO_0000425832"
SQ   SEQUENCE   90 AA;  10491 MW;  35EDD41B338D1DF5 CRC64;
     MKLQLIVVLL IALVIVSLVD GEMLEKRCKN RLKKCTSNSE CCDKKDRGGR KLRCLTXCDE
     RHCLTYKQCL FYPGLQKVKR LCFTYCRCTI