KV5A1_MOUSE
ID KV5A1_MOUSE Reviewed; 149 AA.
AC P01633;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=Immunoglobulin kappa chain variable 6-17 {ECO:0000312|MGI:MGI:1330833};
DE AltName: Full=Ig kappa chain V-V region MPC11;
DE AltName: Full=Ig kappa chain V19-17;
DE Flags: Precursor;
GN Name=Igkv6-17 {ECO:0000312|MGI:MGI:1330833};
GN Synonyms=Igk-V19-17 {ECO:0000305};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-71.
RX PubMed=6288267; DOI=10.1016/0092-8674(82)90184-2;
RA Kelley D.E., Coleclough C., Perry R.P.;
RT "Functional significance and evolutionary development of the 5'-terminal
RT regions of immunoglobulin variable-region genes.";
RL Cell 29:681-689(1982).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-149.
RX PubMed=6245773; DOI=10.1139/o80-024;
RA Rabbitts T.H., Hamlyn P.H., Matthyssens G., Roe B.A.;
RT "The variability, arrangement, and rearrangement of immunoglobulin genes.";
RL Can. J. Biochem. 58:176-187(1980).
RN [3]
RP PROTEIN SEQUENCE OF 30-149.
RX PubMed=418775; DOI=10.1042/bj1710337;
RA Smith G.P.;
RT "Sequence of the full-length immunoglobulin kappa-chain of mouse myeloma
RT MPC 11.";
RL Biochem. J. 171:337-347(1978).
CC -!- MISCELLANEOUS: The mature chain has 12 additional residues at its amino
CC end, due to a tandem duplication of 36 nucleotides after the codon for
CC residue 36. Residue 42 corresponds to the N-terminal residue of typical
CC kappa chains.
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DR EMBL; J00561; AAA38776.1; -; Genomic_DNA.
DR PIR; A90823; KVMS11.
DR PIR; PQ0265; PQ0265.
DR AlphaFoldDB; P01633; -.
DR SMR; P01633; -.
DR MaxQB; P01633; -.
DR PeptideAtlas; P01633; -.
DR PRIDE; P01633; -.
DR ProteomicsDB; 263683; -.
DR MGI; MGI:1330833; Igkv6-17.
DR InParanoid; P01633; -.
DR PhylomeDB; P01633; -.
DR ChiTaRS; Igkv6-17; mouse.
DR PRO; PR:P01633; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P01633; protein.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0019814; C:immunoglobulin complex; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW Adaptive immunity; Direct protein sequencing; Immunity; Immunoglobulin;
KW Reference proteome; Repeat; Signal.
FT SIGNAL 1..29
FT /evidence="ECO:0000269|PubMed:418775"
FT CHAIN 30..149
FT /note="Immunoglobulin kappa chain variable 6-17"
FT /id="PRO_0000015189"
FT REPEAT 26..35
FT REPEAT 38..47
FT REGION 42..64
FT /note="Framework-1"
FT REGION 65..75
FT /note="Complementarity-determining-1"
FT REGION 76..90
FT /note="Framework-2"
FT REGION 91..97
FT /note="Complementarity-determining-2"
FT REGION 98..129
FT /note="Framework-3"
FT REGION 130..138
FT /note="Complementarity-determining-3"
FT REGION 139..148
FT /note="Framework-4"
FT NON_TER 149
SQ SEQUENCE 149 AA; 16434 MW; B0480C87B682AC3E CRC64;
MHHTSMGIKM ESQIQVFVFV FLWLSGVDGD IVMTQFAGVD GDIVMTQSHK FMSTSVGDRV
SITCKASQDV STTVAWYQQK PGQSPKLLIY SASYRYTGVP DRFTGSGSGT DFTFTISSVQ
AEDLAVYYCQ QHYSTPPTFG GGTKLEIKR
