KV5A2_MOUSE
ID KV5A2_MOUSE Reviewed; 136 AA.
AC P01634;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 25-MAY-2022, entry version 130.
DE RecName: Full=Ig kappa chain V-V region MOPC 21;
DE Flags: Precursor;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=6170937; DOI=10.1093/nar/9.18.4485;
RA Hamlyn P.H., Gait M.J., Milstein C.;
RT "Complete sequence of an immunoglobulin mRNA using specific priming and the
RT dideoxynucleotide method of RNA sequencing.";
RL Nucleic Acids Res. 9:4485-4494(1981).
RN [2]
RP PROTEIN SEQUENCE OF 30-136.
RX PubMed=4638343; DOI=10.1042/bj1280427;
RA Svasti J., Milstein C.;
RT "The complete amino acid sequence of a mouse kappa light chain.";
RL Biochem. J. 128:427-444(1972).
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DR EMBL; V00810; CAA24192.1; ALT_TERM; mRNA.
DR PIR; A93736; KVMS21.
DR PIR; I33932; I33932.
DR PDB; 1IGC; X-ray; 2.60 A; L=30-136.
DR PDB; 1UYW; X-ray; 2.00 A; L/N=30-136.
DR PDB; 3J42; EM; 21.00 A; H/J/L=30-136.
DR PDB; 4KVC; X-ray; 2.31 A; L=30-136.
DR PDBsum; 1IGC; -.
DR PDBsum; 1UYW; -.
DR PDBsum; 3J42; -.
DR PDBsum; 4KVC; -.
DR AlphaFoldDB; P01634; -.
DR SMR; P01634; -.
DR MaxQB; P01634; -.
DR PRIDE; P01634; -.
DR InParanoid; P01634; -.
DR PhylomeDB; P01634; -.
DR EvolutionaryTrace; P01634; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P01634; protein.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0019814; C:immunoglobulin complex; IEA:UniProtKB-KW.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Adaptive immunity; Direct protein sequencing; Immunity;
KW Immunoglobulin; Reference proteome; Signal.
FT SIGNAL 1..29
FT /evidence="ECO:0000269|PubMed:4638343"
FT CHAIN 30..136
FT /note="Ig kappa chain V-V region MOPC 21"
FT /id="PRO_0000015190"
FT REGION 30..52
FT /note="Framework-1"
FT REGION 53..63
FT /note="Complementarity-determining-1"
FT REGION 64..78
FT /note="Framework-2"
FT REGION 79..85
FT /note="Complementarity-determining-2"
FT REGION 86..117
FT /note="Framework-3"
FT REGION 118..126
FT /note="Complementarity-determining-3"
FT REGION 127..136
FT /note="Framework-4"
FT NON_TER 136
FT STRAND 33..36
FT /evidence="ECO:0007829|PDB:4KVC"
FT STRAND 38..42
FT /evidence="ECO:0007829|PDB:4KVC"
FT STRAND 46..60
FT /evidence="ECO:0007829|PDB:4KVC"
FT STRAND 62..67
FT /evidence="ECO:0007829|PDB:4KVC"
FT STRAND 74..78
FT /evidence="ECO:0007829|PDB:4KVC"
FT TURN 79..81
FT /evidence="ECO:0007829|PDB:4KVC"
FT STRAND 91..106
FT /evidence="ECO:0007829|PDB:4KVC"
FT HELIX 109..111
FT /evidence="ECO:0007829|PDB:4KVC"
FT STRAND 113..119
FT /evidence="ECO:0007829|PDB:4KVC"
FT STRAND 121..124
FT /evidence="ECO:0007829|PDB:4KVC"
FT STRAND 131..135
FT /evidence="ECO:0007829|PDB:4KVC"
SQ SEQUENCE 136 AA; 14902 MW; 8CDD85113996D1C2 CRC64;
MHQTSMGIKM ESHTLVFISI LLCLYGADGN IVMTQSPKSM SMSVGERVTL TCKASENVVT
YVSWYQQKPE QSPKLLIYGA SNRYTGVPDR FTGSGSATDF TLTISSVQAE DLADYHCGQG
YSYPYTFGGG TKLEIK
