KV5A3_MOUSE
ID KV5A3_MOUSE Reviewed; 115 AA.
AC P01635;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Immunoglobulin kappa chain variable 12-41 {ECO:0000312|MGI:MGI:4439772};
DE AltName: Full=Ig kappa chain V-V region K2;
DE Flags: Precursor; Fragment;
GN Name=Igkv12-41 {ECO:0000312|MGI:MGI:4439772};
GN Synonyms=Gm16848 {ECO:0000312|MGI:MGI:4439772};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6767723; DOI=10.1016/s0021-9258(19)85759-9;
RA Nishioka Y., Leder P.;
RT "Organization and complete sequence of identical embryonic and plasmacytoma
RT kappa V-region genes.";
RL J. Biol. Chem. 255:3691-3694(1980).
CC -!- MISCELLANEOUS: The gene was isolated and sequenced separately from two
CC different sources, embryos and cultured plasmacytoma cells that secrete
CC the similar kappa chain MOPC 149.
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DR EMBL; V00778; CAA24155.1; -; Genomic_DNA.
DR PIR; A01918; KVMSK2.
DR PDB; 1A2Y; X-ray; 1.50 A; A=21-115.
DR PDB; 1A7N; X-ray; 2.01 A; L=21-115.
DR PDB; 1A7O; X-ray; 2.00 A; L=21-115.
DR PDB; 1A7P; X-ray; 2.01 A; L=21-115.
DR PDB; 1A7Q; X-ray; 2.00 A; L=21-115.
DR PDB; 1A7R; X-ray; 2.01 A; L=21-115.
DR PDB; 1DVF; X-ray; 1.90 A; A=21-115.
DR PDB; 1KIP; X-ray; 2.10 A; A=21-115.
DR PDB; 1KIQ; X-ray; 1.85 A; A=21-115.
DR PDB; 1QBL; X-ray; 2.26 A; L=21-115.
DR PDB; 1QBM; X-ray; 2.37 A; L=21-115.
DR PDB; 1VFA; X-ray; 1.80 A; A=21-115.
DR PDB; 1VFB; X-ray; 1.80 A; A=21-115.
DR PDB; 1WEJ; X-ray; 1.80 A; L=21-115.
DR PDBsum; 1A2Y; -.
DR PDBsum; 1A7N; -.
DR PDBsum; 1A7O; -.
DR PDBsum; 1A7P; -.
DR PDBsum; 1A7Q; -.
DR PDBsum; 1A7R; -.
DR PDBsum; 1DVF; -.
DR PDBsum; 1KIP; -.
DR PDBsum; 1KIQ; -.
DR PDBsum; 1QBL; -.
DR PDBsum; 1QBM; -.
DR PDBsum; 1VFA; -.
DR PDBsum; 1VFB; -.
DR PDBsum; 1WEJ; -.
DR AlphaFoldDB; P01635; -.
DR SMR; P01635; -.
DR MINT; P01635; -.
DR CPTAC; non-CPTAC-3653; -.
DR MaxQB; P01635; -.
DR PRIDE; P01635; -.
DR Ensembl; ENSMUST00000103369; ENSMUSP00000100170; ENSMUSG00000095007.
DR MGI; MGI:4439772; Igkv12-41.
DR VEuPathDB; HostDB:ENSMUSG00000095007; -.
DR GeneTree; ENSGT00940000153924; -.
DR HOGENOM; CLU_077975_4_1_1; -.
DR OMA; GANCDIM; -.
DR EvolutionaryTrace; P01635; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; P01635; protein.
DR Bgee; ENSMUSG00000095007; Expressed in colon and 24 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0019814; C:immunoglobulin complex; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Adaptive immunity; Disulfide bond; Immunity; Immunoglobulin;
KW Reference proteome; Signal.
FT SIGNAL 1..20
FT CHAIN 21..>115
FT /note="Immunoglobulin kappa chain variable 12-41"
FT /id="PRO_0000015191"
FT REGION 21..43
FT /note="Framework-1"
FT REGION 44..54
FT /note="Complementarity-determining-1"
FT REGION 55..69
FT /note="Framework-2"
FT REGION 70..76
FT /note="Complementarity-determining-2"
FT REGION 77..108
FT /note="Framework-3"
FT REGION 109..>115
FT /note="Complementarity-determining-3"
FT DISULFID 43..108
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT NON_TER 115
FT STRAND 24..27
FT /evidence="ECO:0007829|PDB:1A2Y"
FT STRAND 29..33
FT /evidence="ECO:0007829|PDB:1A2Y"
FT STRAND 39..47
FT /evidence="ECO:0007829|PDB:1A2Y"
FT STRAND 53..58
FT /evidence="ECO:0007829|PDB:1A2Y"
FT STRAND 65..69
FT /evidence="ECO:0007829|PDB:1A2Y"
FT TURN 70..72
FT /evidence="ECO:0007829|PDB:1A2Y"
FT STRAND 82..87
FT /evidence="ECO:0007829|PDB:1A2Y"
FT STRAND 90..97
FT /evidence="ECO:0007829|PDB:1A2Y"
FT HELIX 100..102
FT /evidence="ECO:0007829|PDB:1A2Y"
FT STRAND 104..110
FT /evidence="ECO:0007829|PDB:1A2Y"
FT STRAND 112..115
FT /evidence="ECO:0007829|PDB:1A2Y"
SQ SEQUENCE 115 AA; 12581 MW; 4F41E3D40C539DEC CRC64;
MSVLTQVLAL LLLWLTGARC DIQMTQSPAS LSASVGETVT ITCRASGNIH NYLAWYQQKQ
GKSPQLLVYN AKTLADGVPS RFSGSGSGTQ YSLKINSLQP EDFGSYYCQH FWSTP
