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KV5A3_MOUSE
ID   KV5A3_MOUSE             Reviewed;         115 AA.
AC   P01635;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 157.
DE   RecName: Full=Immunoglobulin kappa chain variable 12-41 {ECO:0000312|MGI:MGI:4439772};
DE   AltName: Full=Ig kappa chain V-V region K2;
DE   Flags: Precursor; Fragment;
GN   Name=Igkv12-41 {ECO:0000312|MGI:MGI:4439772};
GN   Synonyms=Gm16848 {ECO:0000312|MGI:MGI:4439772};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6767723; DOI=10.1016/s0021-9258(19)85759-9;
RA   Nishioka Y., Leder P.;
RT   "Organization and complete sequence of identical embryonic and plasmacytoma
RT   kappa V-region genes.";
RL   J. Biol. Chem. 255:3691-3694(1980).
CC   -!- MISCELLANEOUS: The gene was isolated and sequenced separately from two
CC       different sources, embryos and cultured plasmacytoma cells that secrete
CC       the similar kappa chain MOPC 149.
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DR   EMBL; V00778; CAA24155.1; -; Genomic_DNA.
DR   PIR; A01918; KVMSK2.
DR   PDB; 1A2Y; X-ray; 1.50 A; A=21-115.
DR   PDB; 1A7N; X-ray; 2.01 A; L=21-115.
DR   PDB; 1A7O; X-ray; 2.00 A; L=21-115.
DR   PDB; 1A7P; X-ray; 2.01 A; L=21-115.
DR   PDB; 1A7Q; X-ray; 2.00 A; L=21-115.
DR   PDB; 1A7R; X-ray; 2.01 A; L=21-115.
DR   PDB; 1DVF; X-ray; 1.90 A; A=21-115.
DR   PDB; 1KIP; X-ray; 2.10 A; A=21-115.
DR   PDB; 1KIQ; X-ray; 1.85 A; A=21-115.
DR   PDB; 1QBL; X-ray; 2.26 A; L=21-115.
DR   PDB; 1QBM; X-ray; 2.37 A; L=21-115.
DR   PDB; 1VFA; X-ray; 1.80 A; A=21-115.
DR   PDB; 1VFB; X-ray; 1.80 A; A=21-115.
DR   PDB; 1WEJ; X-ray; 1.80 A; L=21-115.
DR   PDBsum; 1A2Y; -.
DR   PDBsum; 1A7N; -.
DR   PDBsum; 1A7O; -.
DR   PDBsum; 1A7P; -.
DR   PDBsum; 1A7Q; -.
DR   PDBsum; 1A7R; -.
DR   PDBsum; 1DVF; -.
DR   PDBsum; 1KIP; -.
DR   PDBsum; 1KIQ; -.
DR   PDBsum; 1QBL; -.
DR   PDBsum; 1QBM; -.
DR   PDBsum; 1VFA; -.
DR   PDBsum; 1VFB; -.
DR   PDBsum; 1WEJ; -.
DR   AlphaFoldDB; P01635; -.
DR   SMR; P01635; -.
DR   MINT; P01635; -.
DR   CPTAC; non-CPTAC-3653; -.
DR   MaxQB; P01635; -.
DR   PRIDE; P01635; -.
DR   Ensembl; ENSMUST00000103369; ENSMUSP00000100170; ENSMUSG00000095007.
DR   MGI; MGI:4439772; Igkv12-41.
DR   VEuPathDB; HostDB:ENSMUSG00000095007; -.
DR   GeneTree; ENSGT00940000153924; -.
DR   HOGENOM; CLU_077975_4_1_1; -.
DR   OMA; GANCDIM; -.
DR   EvolutionaryTrace; P01635; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; P01635; protein.
DR   Bgee; ENSMUSG00000095007; Expressed in colon and 24 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0019814; C:immunoglobulin complex; IEA:UniProtKB-KW.
DR   GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Adaptive immunity; Disulfide bond; Immunity; Immunoglobulin;
KW   Reference proteome; Signal.
FT   SIGNAL          1..20
FT   CHAIN           21..>115
FT                   /note="Immunoglobulin kappa chain variable 12-41"
FT                   /id="PRO_0000015191"
FT   REGION          21..43
FT                   /note="Framework-1"
FT   REGION          44..54
FT                   /note="Complementarity-determining-1"
FT   REGION          55..69
FT                   /note="Framework-2"
FT   REGION          70..76
FT                   /note="Complementarity-determining-2"
FT   REGION          77..108
FT                   /note="Framework-3"
FT   REGION          109..>115
FT                   /note="Complementarity-determining-3"
FT   DISULFID        43..108
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   NON_TER         115
FT   STRAND          24..27
FT                   /evidence="ECO:0007829|PDB:1A2Y"
FT   STRAND          29..33
FT                   /evidence="ECO:0007829|PDB:1A2Y"
FT   STRAND          39..47
FT                   /evidence="ECO:0007829|PDB:1A2Y"
FT   STRAND          53..58
FT                   /evidence="ECO:0007829|PDB:1A2Y"
FT   STRAND          65..69
FT                   /evidence="ECO:0007829|PDB:1A2Y"
FT   TURN            70..72
FT                   /evidence="ECO:0007829|PDB:1A2Y"
FT   STRAND          82..87
FT                   /evidence="ECO:0007829|PDB:1A2Y"
FT   STRAND          90..97
FT                   /evidence="ECO:0007829|PDB:1A2Y"
FT   HELIX           100..102
FT                   /evidence="ECO:0007829|PDB:1A2Y"
FT   STRAND          104..110
FT                   /evidence="ECO:0007829|PDB:1A2Y"
FT   STRAND          112..115
FT                   /evidence="ECO:0007829|PDB:1A2Y"
SQ   SEQUENCE   115 AA;  12581 MW;  4F41E3D40C539DEC CRC64;
     MSVLTQVLAL LLLWLTGARC DIQMTQSPAS LSASVGETVT ITCRASGNIH NYLAWYQQKQ
     GKSPQLLVYN AKTLADGVPS RFSGSGSGTQ YSLKINSLQP EDFGSYYCQH FWSTP
 
 
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