KV5A7_MOUSE
ID KV5A7_MOUSE Reviewed; 130 AA.
AC P01639; P01640;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Immunoglobulin kappa chain variable 9-120 {ECO:0000312|MGI:MGI:3647784};
DE AltName: Full=Ig kappa chain V-V region MOPC 41 {ECO:0000305};
DE Flags: Precursor;
GN Name=Igkv9-120 {ECO:0000312|MGI:MGI:3647784};
GN Synonyms=Gm5571 {ECO:0000312|MGI:MGI:3647784};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=111146; DOI=10.1038/280370a0;
RA Seidman J.G., Max E.E., Leder P.;
RT "A kappa-immunoglobulin gene is formed by site-specific recombination
RT without further somatic mutation.";
RL Nature 280:370-375(1979).
RN [2]
RP PROTEIN SEQUENCE OF 1-33 (PRECURSOR PROTEIN).
RX PubMed=403522; DOI=10.1073/pnas.74.2.716;
RA Burstein Y., Schechter I.;
RT "Amino acid sequence of the NH2-terminal extra piece segments of the
RT precursors of mouse immunoglobulin lambda1-type and kappa-type light
RT chains.";
RL Proc. Natl. Acad. Sci. U.S.A. 74:716-720(1977).
RN [3]
RP PROTEIN SEQUENCE OF 23-130.
RX PubMed=4162931; DOI=10.1126/science.155.3761.465;
RA Gray W.R., Dreyer W.J., Hood L.E.;
RT "Mechanism of antibody synthesis: size differences between mouse kappa
RT chains.";
RL Science 155:465-467(1967).
CC -!- MISCELLANEOUS: This precursor was synthesized in a cell-free system
CC directed by mRNA isolated from myeloma polysomes.
CC -!- MISCELLANEOUS: This is a Bence-Jones protein.
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DR PIR; A93211; KVMSM4.
DR PIR; PL0259; PL0259.
DR PIR; PL0260; PL0260.
DR PIR; PL0261; PL0261.
DR AlphaFoldDB; P01639; -.
DR SMR; P01639; -.
DR CPTAC; non-CPTAC-3539; -.
DR MaxQB; P01639; -.
DR PeptideAtlas; P01639; -.
DR PRIDE; P01639; -.
DR ProteomicsDB; 264812; -.
DR MGI; MGI:3647784; Igkv9-120.
DR InParanoid; P01639; -.
DR PhylomeDB; P01639; -.
DR Reactome; R-MMU-166663; Initial triggering of complement.
DR Reactome; R-MMU-173623; Classical antibody-mediated complement activation.
DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR Reactome; R-MMU-202733; Cell surface interactions at the vascular wall.
DR Reactome; R-MMU-2029481; FCGR activation.
DR Reactome; R-MMU-2029482; Regulation of actin dynamics for phagocytic cup formation.
DR Reactome; R-MMU-2029485; Role of phospholipids in phagocytosis.
DR Reactome; R-MMU-2168880; Scavenging of heme from plasma.
DR Reactome; R-MMU-2454202; Fc epsilon receptor (FCERI) signaling.
DR Reactome; R-MMU-2730905; Role of LAT2/NTAL/LAB on calcium mobilization.
DR Reactome; R-MMU-2871796; FCERI mediated MAPK activation.
DR Reactome; R-MMU-2871809; FCERI mediated Ca+2 mobilization.
DR Reactome; R-MMU-2871837; FCERI mediated NF-kB activation.
DR Reactome; R-MMU-5690714; CD22 mediated BCR regulation.
DR Reactome; R-MMU-977606; Regulation of Complement cascade.
DR Reactome; R-MMU-983695; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
DR ChiTaRS; Igkv9-120; mouse.
DR PRO; PR:P01639; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P01639; protein.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0019814; C:immunoglobulin complex; IEA:UniProtKB-KW.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW Adaptive immunity; Bence-Jones protein; Direct protein sequencing;
KW Disulfide bond; Immunity; Immunoglobulin; Reference proteome; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000269|PubMed:403522,
FT ECO:0000269|PubMed:4162931"
FT CHAIN 23..130
FT /note="Immunoglobulin kappa chain variable 9-120"
FT /id="PRO_0000015194"
FT REGION 23..45
FT /note="Framework-1"
FT REGION 46..56
FT /note="Complementarity-determining-1"
FT REGION 57..71
FT /note="Framework-2"
FT REGION 72..78
FT /note="Complementarity-determining-2"
FT REGION 79..110
FT /note="Framework-3"
FT REGION 111..119
FT /note="Complementarity-determining-3"
FT REGION 120..129
FT /note="Framework-4"
FT DISULFID 45..110
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VARIANT 1..2
FT /note="Missing (in 25% of the molecules)"
FT NON_TER 130
SQ SEQUENCE 130 AA; 14311 MW; 5EFE0FE71D5F1BEC CRC64;
MDMRAPAQIF GFLLLLFQGT RCDIQMTQSP SSLSASLGER VSLTCRASQD IGSSLNWLQQ
EPDGTIKRLI YATSSLDSGV PKRFSGSRSG SDYSLTISSL ESEDFVDYYC LQYASSPWTF
GGGTKLEIKR
