ID   KXA4_MESEU              Reviewed;          63 AA.
AC   E4VP41;
DT   31-JAN-2018, integrated into UniProtKB/Swiss-Prot.
DT   08-FEB-2011, sequence version 1.
DT   25-MAY-2022, entry version 14.
DE   RecName: Full=Potassium channel toxin MeuTXKalpha4 {ECO:0000303|PubMed:20889474};
DE   AltName: Full=Venom antimicrobial peptide-8 {ECO:0000312|EMBL:ABR21058.1};
DE   Flags: Precursor;
OS   Mesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus.
OX   NCBI_TaxID=34648;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=20889474; DOI=10.1074/mcp.m110.002832;
RA   Zhu S., Peigneur S., Gao B., Luo L., Jin D., Zhao Y., Tytgat J.;
RT   "Molecular diversity and functional evolution of scorpion potassium channel
RT   toxins.";
RL   Mol. Cell. Proteomics 10:M110.002832-M110.002832(2011).
CC   -!- FUNCTION: May block voltage-gated potassium channels (Kv).
CC       {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:20889474}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:20889474}.
CC   -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC       channel inhibitor family. {ECO:0000305}.
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DR   EMBL; EF445083; ABR21058.1; -; mRNA.
DR   AlphaFoldDB; E4VP41; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Disulfide bond; Ion channel impairing toxin;
KW   Potassium channel impairing toxin; Secreted; Signal; Toxin;
KW   Voltage-gated potassium channel impairing toxin.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..63
FT                   /note="Potassium channel toxin MeuTXKalpha4"
FT                   /evidence="ECO:0000305|PubMed:20889474"
FT                   /id="PRO_5003189730"
FT   DISULFID        35..53
FT                   /evidence="ECO:0000250|UniProtKB:P0DL65"
FT   DISULFID        39..59
FT                   /evidence="ECO:0000250|UniProtKB:P0DL65"
FT   DISULFID        43..61
FT                   /evidence="ECO:0000250|UniProtKB:P0DL65"
SQ   SEQUENCE   63 AA;  7104 MW;  DA7A0F98D328D2A5 CRC64;
     MSRLLIFILT AVVLSVIIDI LNNSKVEGQY CCYTCIPDCS KSCQDSGLRF KACIPYRSCL
     CQY