ID   KXD1_ASHGO              Reviewed;         190 AA.
AC   Q755A2;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit KXD1;
DE            Short=BLOC-1 subunit KXD1;
DE   AltName: Full=KxDL homolog;
GN   Name=KXD1; OrderedLocusNames=AFL077C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Component of the biogenesis of lysosome-related organelles
CC       complex-1 (BLOC-1) involved in endosomal cargo sorting. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC       complex-1 (BLOC-1). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the KXD1 family. {ECO:0000305}.
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DR   EMBL; AE016819; AAS53295.1; -; Genomic_DNA.
DR   RefSeq; NP_985471.1; NM_210825.1.
DR   AlphaFoldDB; Q755A2; -.
DR   SMR; Q755A2; -.
DR   STRING; 33169.AAS53295; -.
DR   EnsemblFungi; AAS53295; AAS53295; AGOS_AFL077C.
DR   GeneID; 4621700; -.
DR   KEGG; ago:AGOS_AFL077C; -.
DR   eggNOG; ENOG502S1H5; Eukaryota.
DR   HOGENOM; CLU_099155_0_0_1; -.
DR   InParanoid; Q755A2; -.
DR   OMA; PIEYNQS; -.
DR   Proteomes; UP000000591; Chromosome VI.
DR   GO; GO:0031083; C:BLOC-1 complex; IBA:GO_Central.
DR   GO; GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0007032; P:endosome organization; IBA:GO_Central.
DR   GO; GO:0032880; P:regulation of protein localization; IBA:GO_Central.
DR   InterPro; IPR019371; Uncharacterised_KxDL.
DR   Pfam; PF10241; KxDL; 1.
PE   3: Inferred from homology;
KW   Endosome; Reference proteome; Transport.
FT   CHAIN           1..190
FT                   /note="Biogenesis of lysosome-related organelles complex 1
FT                   subunit KXD1"
FT                   /id="PRO_0000410666"
FT   REGION          1..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        30..44
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   190 AA;  21013 MW;  5531C3BF39311778 CRC64;
     MSDDVDSETR SRTPSISSRQ FIIPEDELAT LDSENSSLDS GGEEASSGGS DAYSAAGGST
     PVFSRLGQHP STFFTGSQVA PIFDTSLYLF ESLTQSLDSV DFSEALSLQT KTSATINSKS
     RELQLLVGEV QTHLRRLQTA FEQGQHTAQR VRHNLRDITR GVESLKQTFA RSYPIEYHQA
     LERAYERRAE