ID   KXD1_KLULA              Reviewed;         178 AA.
AC   Q6CMK9;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit KXD1;
DE            Short=BLOC-1 subunit KXD1;
DE   AltName: Full=KxDL homolog;
GN   Name=KXD1; OrderedLocusNames=KLLA0E19427g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the biogenesis of lysosome-related organelles
CC       complex-1 (BLOC-1) involved in endosomal cargo sorting. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC       complex-1 (BLOC-1). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the KXD1 family. {ECO:0000305}.
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DR   EMBL; CR382125; CAG99917.1; -; Genomic_DNA.
DR   RefSeq; XP_454830.1; XM_454830.1.
DR   AlphaFoldDB; Q6CMK9; -.
DR   SMR; Q6CMK9; -.
DR   STRING; 28985.XP_454830.1; -.
DR   EnsemblFungi; CAG99917; CAG99917; KLLA0_E19427g.
DR   GeneID; 2893961; -.
DR   KEGG; kla:KLLA0_E19427g; -.
DR   eggNOG; ENOG502S1H5; Eukaryota.
DR   HOGENOM; CLU_099155_0_0_1; -.
DR   InParanoid; Q6CMK9; -.
DR   OMA; PIEYNQS; -.
DR   Proteomes; UP000000598; Chromosome E.
DR   GO; GO:0031083; C:BLOC-1 complex; IEA:EnsemblFungi.
DR   GO; GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0007032; P:endosome organization; IEA:EnsemblFungi.
DR   GO; GO:0032880; P:regulation of protein localization; IEA:EnsemblFungi.
DR   InterPro; IPR019371; Uncharacterised_KxDL.
DR   Pfam; PF10241; KxDL; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Endosome; Reference proteome; Transport.
FT   CHAIN           1..178
FT                   /note="Biogenesis of lysosome-related organelles complex 1
FT                   subunit KXD1"
FT                   /id="PRO_0000410668"
FT   REGION          28..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          101..130
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   178 AA;  20217 MW;  EB82625F983C8899 CRC64;
     MDEHRSRTPS IDSRNYAIPE ADYLPAGIDI DRNGVSESDD SSDDDAQSSL FPTESSGTLW
     MNQIQDTPMF DSSKFLFESV NNAINDIDFS ESLAIQAKTS ALINSKSREL KGLIKQLQEK
     VDYYNERFKR GAVVSSQLKV NLQMLSKRIA TLDDLFSKQF PIEYNQSKEK VMERTLND