ID   KXD1_VANPO              Reviewed;         265 AA.
AC   A7TE86;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit KXD1;
DE            Short=BLOC-1 subunit KXD1;
DE   AltName: Full=KxDL homolog;
GN   Name=KXD1; ORFNames=Kpol_1002p55;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Component of the biogenesis of lysosome-related organelles
CC       complex-1 (BLOC-1) involved in endosomal cargo sorting. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC       complex-1 (BLOC-1). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the KXD1 family. {ECO:0000305}.
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DR   EMBL; DS480379; EDO19408.1; -; Genomic_DNA.
DR   RefSeq; XP_001647266.1; XM_001647216.1.
DR   AlphaFoldDB; A7TE86; -.
DR   STRING; 436907.A7TE86; -.
DR   EnsemblFungi; EDO19408; EDO19408; Kpol_1002p55.
DR   GeneID; 5547758; -.
DR   KEGG; vpo:Kpol_1002p55; -.
DR   eggNOG; ENOG502S1H5; Eukaryota.
DR   HOGENOM; CLU_099155_0_0_1; -.
DR   InParanoid; A7TE86; -.
DR   OrthoDB; 1469363at2759; -.
DR   PhylomeDB; A7TE86; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019371; Uncharacterised_KxDL.
DR   Pfam; PF10241; KxDL; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Endosome; Reference proteome; Transport.
FT   CHAIN           1..265
FT                   /note="Biogenesis of lysosome-related organelles complex 1
FT                   subunit KXD1"
FT                   /id="PRO_0000410669"
FT   REGION          1..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          79..111
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          196..245
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   265 AA;  29006 MW;  4EA7B0F993C63FEA CRC64;
     MSSDGEEGSF EGSQLVSQSP SINSQTYAIP IPEGMLDQLD ISSSSSSAGG RDDEDEEDDD
     ADVDVGVGSE CLVGVTGQDR LIIGSGDDSD NGDGDEVHDN AHATSDVSST AELNHVCSEE
     TEDMDNVDEG LLDDIMNNTG GGGFVNGFEF HESEPMFDVS KYVFETLIQA INSADFSESL
     AFQTKTSAVI NAKSLELKQL INMSKDRLVD LQDKFEKGVQ TSNRIKRNLK MSREKIQFLN
     DEFRTNYPIE FNQARDKIIE RTIDS