KXD1_YEASA
ID KXD1_YEASA Reviewed; 218 AA.
AC E7KCH3;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 1.
DT 25-MAY-2022, entry version 28.
DE RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit KXD1;
DE Short=BLOC-1 subunit KXD1;
DE AltName: Full=KxDL homolog;
GN Name=KXD1; ORFNames=AWRI796_1718;
OS Saccharomyces cerevisiae (strain AWRI796) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=764097;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AWRI796;
RX PubMed=21304888; DOI=10.1371/journal.pgen.1001287;
RA Borneman A.R., Desany B.A., Riches D., Affourtit J.P., Forgan A.H.,
RA Pretorius I.S., Egholm M., Chambers P.J.;
RT "Whole-genome comparison reveals novel genetic elements that characterize
RT the genome of industrial strains of Saccharomyces cerevisiae.";
RL PLoS Genet. 7:E1001287-E1001287(2011).
CC -!- FUNCTION: Component of the biogenesis of lysosome-related organelles
CC complex-1 (BLOC-1) involved in endosomal cargo sorting. {ECO:0000250}.
CC -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC complex-1 (BLOC-1) composed of at least BLI1, BLS1, CNL1, KXD1, SNN1
CC and VAB2. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endosome {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the KXD1 family. {ECO:0000305}.
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DR EMBL; ADVS01000023; EGA75071.1; -; Genomic_DNA.
DR AlphaFoldDB; E7KCH3; -.
DR SMR; E7KCH3; -.
DR HOGENOM; CLU_099155_0_0_1; -.
DR OMA; PIEYNQS; -.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
DR InterPro; IPR019371; Uncharacterised_KxDL.
DR Pfam; PF10241; KxDL; 1.
PE 3: Inferred from homology;
KW Coiled coil; Endosome; Transport.
FT CHAIN 1..218
FT /note="Biogenesis of lysosome-related organelles complex 1
FT subunit KXD1"
FT /id="PRO_0000410674"
FT REGION 1..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 142..192
FT /evidence="ECO:0000255"
FT COMPBIAS 16..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 218 AA; 24442 MW; 61541771FBEC8F8C CRC64;
MVTGISEEND DEETFSAVHS STPSINSQSY AIPITEEMSS SFHDSISTTS NSSGSFDSDG
SNVSDVVEQN EMDNESNVDE DLFLDNDIPQ SSNLLPTDAQ DPGPIFDVSR YIFDSLKQSI
DSADFSEALS LQTKTSAVIN SKSLELKQYI DEMKSRLTQL QEKFENGEAT SKKIKRDLET
SRKNIDYLNA ALRVDFPIEF NQAREKILER RLNEDHDC