KXD1_YEAST
ID KXD1_YEAST Reviewed; 218 AA.
AC P53158; D6VU65;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit KXD1;
DE Short=BLOC-1 subunit KXD1;
DE AltName: Full=KxDL homolog;
GN Name=KXD1; OrderedLocusNames=YGL079W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9290212;
RX DOI=10.1002/(sici)1097-0061(19970915)13:11<1077::aid-yea152>3.0.co;2-y;
RA Rieger M., Brueckner M., Schaefer M., Mueller-Auer S.;
RT "Sequence analysis of 203 kilobases from Saccharomyces cerevisiae
RT chromosome VII.";
RL Yeast 13:1077-1090(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169869;
RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL Nature 387:81-84(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [6]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [7]
RP IDENTIFICATION IN THE BLOC-1 COMPLEX, AND FUNCTION.
RX PubMed=21159114; DOI=10.1111/j.1600-0854.2010.01151.x;
RA Hayes M.J., Bryon K., Satkurunathan J., Levine T.P.;
RT "Yeast homologues of three BLOC-1 subunits highlight KxDL proteins as
RT conserved interactors of BLOC-1.";
RL Traffic 12:260-268(2011).
CC -!- FUNCTION: Component of the biogenesis of lysosome-related organelles
CC complex-1 (BLOC-1) involved in endosomal cargo sorting.
CC {ECO:0000269|PubMed:21159114}.
CC -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC complex-1 (BLOC-1) composed of at least BLI1, BLS1, CNL1, KXD1, SNN1
CC and VAB2. {ECO:0000269|PubMed:21159114}.
CC -!- SUBCELLULAR LOCATION: Endosome {ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: Present with 1630 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the KXD1 family. {ECO:0000305}.
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DR EMBL; Z72601; CAA96784.1; -; Genomic_DNA.
DR EMBL; AY558485; AAS56811.1; -; Genomic_DNA.
DR EMBL; BK006941; DAA08026.1; -; Genomic_DNA.
DR PIR; S64086; S64086.
DR RefSeq; NP_011436.1; NM_001180944.1.
DR AlphaFoldDB; P53158; -.
DR SMR; P53158; -.
DR BioGRID; 33171; 93.
DR ComplexPortal; CPX-1153; BLOC-1 complex.
DR DIP; DIP-5247N; -.
DR IntAct; P53158; 7.
DR MINT; P53158; -.
DR STRING; 4932.YGL079W; -.
DR MaxQB; P53158; -.
DR PaxDb; P53158; -.
DR PRIDE; P53158; -.
DR EnsemblFungi; YGL079W_mRNA; YGL079W; YGL079W.
DR GeneID; 852801; -.
DR KEGG; sce:YGL079W; -.
DR SGD; S000003047; KXD1.
DR VEuPathDB; FungiDB:YGL079W; -.
DR eggNOG; ENOG502S1H5; Eukaryota.
DR HOGENOM; CLU_099155_0_0_1; -.
DR InParanoid; P53158; -.
DR OMA; PIEYNQS; -.
DR BioCyc; YEAST:G3O-30580-MON; -.
DR PRO; PR:P53158; -.
DR Proteomes; UP000002311; Chromosome VII.
DR RNAct; P53158; protein.
DR GO; GO:0031083; C:BLOC-1 complex; IDA:SGD.
DR GO; GO:0005768; C:endosome; IDA:ComplexPortal.
DR GO; GO:0007032; P:endosome organization; IMP:SGD.
DR GO; GO:0032880; P:regulation of protein localization; IMP:SGD.
DR InterPro; IPR019371; Uncharacterised_KxDL.
DR Pfam; PF10241; KxDL; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Endosome; Reference proteome; Transport.
FT CHAIN 1..218
FT /note="Biogenesis of lysosome-related organelles complex 1
FT subunit KXD1"
FT /id="PRO_0000202759"
FT REGION 1..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 142..192
FT /evidence="ECO:0000255"
FT MOTIF 175..179
FT /note="KxDL"
FT COMPBIAS 16..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 218 AA; 24442 MW; 61541771FBEC8F8C CRC64;
MVTGISEEND DEETFSAVHS STPSINSQSY AIPITEEMSS SFHDSISTTS NSSGSFDSDG
SNVSDVVEQN EMDNESNVDE DLFLDNDIPQ SSNLLPTDAQ DPGPIFDVSR YIFDSLKQSI
DSADFSEALS LQTKTSAVIN SKSLELKQYI DEMKSRLTQL QEKFENGEAT SKKIKRDLET
SRKNIDYLNA ALRVDFPIEF NQAREKILER RLNEDHDC
