ID   KXDL1_BOVIN             Reviewed;         176 AA.
AC   Q3SZV2;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=KxDL motif-containing protein 1;
GN   Name=KXD1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: As part of the BORC complex may play a role in lysosomes
CC       movement and localization at the cell periphery. Associated with the
CC       cytosolic face of lysosomes, the BORC complex may recruit ARL8B and
CC       couple lysosomes to microtubule plus-end-directed kinesin motor. May
CC       also be involved in the biogenesis of lysosome-related organelles such
CC       as melanosomes. {ECO:0000250|UniProtKB:Q80XH1,
CC       ECO:0000250|UniProtKB:Q9BQD3}.
CC   -!- SUBUNIT: Component of the BLOC-one-related complex (BORC) which is
CC       composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and
CC       SNAPIN. Associates with the BLOC-1 complex. Interacts with BLOC1S1.
CC       Interacts with DTNBP1/BLOC1S7 (via coiled-coil domain).
CC       {ECO:0000250|UniProtKB:Q80XH1, ECO:0000250|UniProtKB:Q9BQD3}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q9BQD3}.
CC   -!- SIMILARITY: Belongs to the KXD1 family. {ECO:0000305}.
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DR   EMBL; BC102692; AAI02693.1; -; mRNA.
DR   RefSeq; NP_001029777.1; NM_001034605.2.
DR   AlphaFoldDB; Q3SZV2; -.
DR   SMR; Q3SZV2; -.
DR   STRING; 9913.ENSBTAP00000013943; -.
DR   PaxDb; Q3SZV2; -.
DR   PRIDE; Q3SZV2; -.
DR   GeneID; 534253; -.
DR   KEGG; bta:534253; -.
DR   CTD; 79036; -.
DR   eggNOG; KOG3443; Eukaryota.
DR   InParanoid; Q3SZV2; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0099078; C:BORC complex; ISS:UniProtKB.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032418; P:lysosome localization; ISS:UniProtKB.
DR   GO; GO:0016192; P:vesicle-mediated transport; ISS:UniProtKB.
DR   InterPro; IPR039843; KXD1-like.
DR   InterPro; IPR019371; Uncharacterised_KxDL.
DR   PANTHER; PTHR13511; PTHR13511; 1.
DR   Pfam; PF10241; KxDL; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Lysosome; Membrane; Reference proteome.
FT   CHAIN           1..176
FT                   /note="KxDL motif-containing protein 1"
FT                   /id="PRO_0000295258"
FT   REGION          95..176
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        117..147
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BQD3"
SQ   SEQUENCE   176 AA;  19635 MW;  B340982461F06A0A CRC64;
     MDPPDSASRV FSSRILSMVN ADDVSAIILA QKNMLDRFEK TNEMLLNFNN LSSARLQQMN
     ERFLHHTRTL VEMKRDLDSI FRRIRTLKGK LARQHPEAFS HIPEASLLED EDEDPIPPST
     TTTIATSEQS TGSCDTSPDT VSPSLSPGFE DLSHIRPGSP AINGRSHTDD EEMPGE