KXDL1_DROME
ID KXDL1_DROME Reviewed; 212 AA.
AC Q9VTY4;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=KxDL motif-containing protein CG10681;
GN ORFNames=CG10681;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Ovary;
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A.,
RA Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A.,
RA Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S.,
RA Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.;
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- INTERACTION:
CC Q9VTY4; Q9W0Q3: BORCS6; NbExp=4; IntAct=EBI-195214, EBI-15108681;
CC Q9VTY4; O97420: CG14818; NbExp=4; IntAct=EBI-195214, EBI-99679;
CC Q9VTY4; Q8IG84: Tm1; NbExp=4; IntAct=EBI-195214, EBI-499181;
CC -!- SIMILARITY: Belongs to the KXD1 family. {ECO:0000305}.
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DR EMBL; AE014296; AAF49911.1; -; Genomic_DNA.
DR EMBL; BT004913; AAO49166.1; -; mRNA.
DR RefSeq; NP_001261766.1; NM_001274837.1.
DR RefSeq; NP_648580.1; NM_140323.2.
DR AlphaFoldDB; Q9VTY4; -.
DR SMR; Q9VTY4; -.
DR BioGRID; 64775; 6.
DR IntAct; Q9VTY4; 11.
DR STRING; 7227.FBpp0075689; -.
DR PaxDb; Q9VTY4; -.
DR DNASU; 39425; -.
DR EnsemblMetazoa; FBtr0075957; FBpp0075689; FBgn0036291.
DR EnsemblMetazoa; FBtr0332634; FBpp0304880; FBgn0036291.
DR GeneID; 39425; -.
DR KEGG; dme:Dmel_CG10681; -.
DR UCSC; CG10681-RA; d. melanogaster.
DR FlyBase; FBgn0036291; CG10681.
DR VEuPathDB; VectorBase:FBgn0036291; -.
DR eggNOG; KOG3443; Eukaryota.
DR GeneTree; ENSGT00530000064192; -.
DR HOGENOM; CLU_094353_0_0_1; -.
DR InParanoid; Q9VTY4; -.
DR OMA; QSDVETM; -.
DR OrthoDB; 1612645at2759; -.
DR PhylomeDB; Q9VTY4; -.
DR BioGRID-ORCS; 39425; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 39425; -.
DR PRO; PR:Q9VTY4; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0036291; Expressed in saliva-secreting gland and 24 other tissues.
DR ExpressionAtlas; Q9VTY4; baseline and differential.
DR Genevisible; Q9VTY4; DM.
DR GO; GO:0099078; C:BORC complex; IBA:GO_Central.
DR GO; GO:0032418; P:lysosome localization; IBA:GO_Central.
DR InterPro; IPR039843; KXD1-like.
DR InterPro; IPR019371; Uncharacterised_KxDL.
DR PANTHER; PTHR13511; PTHR13511; 1.
DR Pfam; PF10241; KxDL; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..212
FT /note="KxDL motif-containing protein CG10681"
FT /id="PRO_0000295265"
FT REGION 128..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..144
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 212 AA; 23411 MW; AC86615C6E1BE86C CRC64;
MSHLGLADVH QSEDATPDLE SFTGFGNSAA EAFIQSLAGM VNQGDVETMI RAQKQMLQRF
EKTNEMLLNC NALSQSRLKS ASEDFKRHVK CLSEMKKDLD YIFRKIRIIK QKLQSQFPAI
YAEVQPQRSS LAEEAEDDTE AQAKKTAETP APAAAKPVLS TKKSAATIEY VQMEEAVDNG
TVEIENELIK RVCSVETANP NDSSDCTSED TG
