ID   KXDL1_RAT               Reviewed;         177 AA.
AC   Q5M853;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=KxDL motif-containing protein 1;
GN   Name=Kxd1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Thymus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: As part of the BORC complex may play a role in lysosomes
CC       movement and localization at the cell periphery. Associated with the
CC       cytosolic face of lysosomes, the BORC complex may recruit ARL8B and
CC       couple lysosomes to microtubule plus-end-directed kinesin motor. May
CC       also be involved in the biogenesis of lysosome-related organelles such
CC       as melanosomes. {ECO:0000250|UniProtKB:Q80XH1,
CC       ECO:0000250|UniProtKB:Q9BQD3}.
CC   -!- SUBUNIT: Component of the BLOC-one-related complex (BORC) which is
CC       composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and
CC       SNAPIN. Associates with the BLOC-1 complex. Interacts with BLOC1S1.
CC       Interacts with DTNBP1/BLOC1S7 (via coiled-coil domain).
CC       {ECO:0000250|UniProtKB:Q80XH1, ECO:0000250|UniProtKB:Q9BQD3}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q9BQD3}.
CC   -!- SIMILARITY: Belongs to the KXD1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC088216; AAH88216.1; -; mRNA.
DR   RefSeq; NP_001020314.1; NM_001025143.1.
DR   RefSeq; XP_006252985.1; XM_006252923.3.
DR   RefSeq; XP_006252986.1; XM_006252924.1.
DR   AlphaFoldDB; Q5M853; -.
DR   SMR; Q5M853; -.
DR   STRING; 10116.ENSRNOP00000027053; -.
DR   iPTMnet; Q5M853; -.
DR   PhosphoSitePlus; Q5M853; -.
DR   PaxDb; Q5M853; -.
DR   GeneID; 498606; -.
DR   KEGG; rno:498606; -.
DR   UCSC; RGD:1562866; rat.
DR   CTD; 79036; -.
DR   RGD; 1562866; Kxd1.
DR   VEuPathDB; HostDB:ENSRNOG00000019971; -.
DR   eggNOG; KOG3443; Eukaryota.
DR   HOGENOM; CLU_094353_3_0_1; -.
DR   InParanoid; Q5M853; -.
DR   OMA; LRMQQMN; -.
DR   OrthoDB; 1612645at2759; -.
DR   PhylomeDB; Q5M853; -.
DR   TreeFam; TF319035; -.
DR   PRO; PR:Q5M853; -.
DR   Proteomes; UP000002494; Chromosome 16.
DR   Bgee; ENSRNOG00000019971; Expressed in ovary and 20 other tissues.
DR   Genevisible; Q5M853; RN.
DR   GO; GO:0031083; C:BLOC-1 complex; ISO:RGD.
DR   GO; GO:0099078; C:BORC complex; ISS:UniProtKB.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032418; P:lysosome localization; ISS:UniProtKB.
DR   GO; GO:0016192; P:vesicle-mediated transport; ISS:UniProtKB.
DR   InterPro; IPR039843; KXD1-like.
DR   InterPro; IPR019371; Uncharacterised_KxDL.
DR   PANTHER; PTHR13511; PTHR13511; 1.
DR   Pfam; PF10241; KxDL; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Lysosome; Membrane; Reference proteome.
FT   CHAIN           1..177
FT                   /note="KxDL motif-containing protein 1"
FT                   /id="PRO_0000295261"
FT   REGION          92..177
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..147
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BQD3"
SQ   SEQUENCE   177 AA;  19913 MW;  9F3DEABC772FEE76 CRC64;
     MDTPDSASRV FCGRFLSMVN TDDVNAIILA QKNMLDRFEK TNEMLLNFNN LSSVRLQQMS
     ERFMHHTRTL VDMKRDLDSI FRRIRTLKGK LARQHPEAFS HIPEGSLLED EDEDPVPPSI
     TTTIATSEQS TGSCDTSPDT ASPSFSPGFE DLSHIRPGSP AINGHSQTDD EEETREE