KXDL1_XENLA
ID KXDL1_XENLA Reviewed; 180 AA.
AC Q6DDT0;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 49.
DE RecName: Full=KxDL motif-containing protein 1;
GN Name=kxd1;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: As part of a BORC-like complex may play a role in lysosomes
CC movement and localization at the cell periphery. Associated with the
CC cytosolic face of lysosomes, this complex may couple lysosomes to
CC microtubule plus-end-directed kinesin motor. May also be involved in
CC the biogenesis of lysosome-related organelles such as melanosomes.
CC {ECO:0000250|UniProtKB:Q80XH1, ECO:0000250|UniProtKB:Q9BQD3}.
CC -!- SUBUNIT: Associates with the BLOC-1 complex.
CC {ECO:0000250|UniProtKB:Q80XH1}.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q9BQD3}.
CC -!- SIMILARITY: Belongs to the KXD1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH77438.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; BC077438; AAH77438.1; ALT_INIT; mRNA.
DR RefSeq; NP_001086784.1; NM_001093315.1.
DR AlphaFoldDB; Q6DDT0; -.
DR SMR; Q6DDT0; -.
DR DNASU; 446619; -.
DR GeneID; 446619; -.
DR KEGG; xla:446619; -.
DR CTD; 446619; -.
DR Xenbase; XB-GENE-5898631; kxd1.L.
DR OrthoDB; 1612645at2759; -.
DR Proteomes; UP000186698; Chromosome 1L.
DR Bgee; 446619; Expressed in oocyte and 19 other tissues.
DR GO; GO:0099078; C:BORC complex; ISS:UniProtKB.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032418; P:lysosome localization; ISS:UniProtKB.
DR GO; GO:0016192; P:vesicle-mediated transport; ISS:UniProtKB.
DR InterPro; IPR039843; KXD1-like.
DR InterPro; IPR019371; Uncharacterised_KxDL.
DR PANTHER; PTHR13511; PTHR13511; 1.
DR Pfam; PF10241; KxDL; 1.
PE 2: Evidence at transcript level;
KW Lysosome; Membrane; Reference proteome.
FT CHAIN 1..180
FT /note="KxDL motif-containing protein 1"
FT /id="PRO_0000295263"
FT REGION 130..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 180 AA; 20208 MW; 1D72EDE94F7C49C1 CRC64;
MAEQVTEATA SGVFCSRILN MVNTGDVNAI ILAQRHMLDR FEKTNEMLLN FNGLSNVRLQ
QMSDRFAHHT RTLVEMKKDL DIIFRRIRML KGKLAKQYPE SFNNVHESPI LEDDDDFDPT
LKSAATTIAT SEQSTESCDT SPSIISPAMS QDFEDLSQAP SDTPSVNGQI LTDEELVHED