ID   ARCA_VIBC1              Reviewed;         406 AA.
AC   A7MSD7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Arginine deiminase {ECO:0000255|HAMAP-Rule:MF_00242};
DE            Short=ADI {ECO:0000255|HAMAP-Rule:MF_00242};
DE            EC=3.5.3.6 {ECO:0000255|HAMAP-Rule:MF_00242};
DE   AltName: Full=Arginine dihydrolase {ECO:0000255|HAMAP-Rule:MF_00242};
DE            Short=AD {ECO:0000255|HAMAP-Rule:MF_00242};
GN   Name=arcA {ECO:0000255|HAMAP-Rule:MF_00242};
GN   OrderedLocusNames=VIBHAR_03644;
OS   Vibrio campbellii (strain ATCC BAA-1116).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=2902295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1116 / BB120;
RG   The Vibrio harveyi Genome Sequencing Project;
RA   Bassler B., Clifton S.W., Fulton L., Delehaunty K., Fronick C.,
RA   Harrison M., Markivic C., Fulton R., Tin-Wollam A.-M., Shah N., Pepin K.,
RA   Nash W., Thiruvilangam P., Bhonagiri V., Waters C., Tu K.C., Irgon J.,
RA   Wilson R.K.;
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-arginine = L-citrulline + NH4(+);
CC         Xref=Rhea:RHEA:19597, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:32682, ChEBI:CHEBI:57743; EC=3.5.3.6;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00242};
CC   -!- PATHWAY: Amino-acid degradation; L-arginine degradation via ADI
CC       pathway; carbamoyl phosphate from L-arginine: step 1/2.
CC       {ECO:0000255|HAMAP-Rule:MF_00242}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00242}.
CC   -!- SIMILARITY: Belongs to the arginine deiminase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00242}.
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DR   EMBL; CP000789; ABU72558.1; -; Genomic_DNA.
DR   RefSeq; WP_005432859.1; NC_022269.1.
DR   AlphaFoldDB; A7MSD7; -.
DR   SMR; A7MSD7; -.
DR   EnsemblBacteria; ABU72558; ABU72558; VIBHAR_03644.
DR   GeneID; 57822555; -.
DR   GeneID; 67376156; -.
DR   KEGG; vha:VIBHAR_03644; -.
DR   PATRIC; fig|338187.25.peg.2592; -.
DR   OMA; WPARHDE; -.
DR   OrthoDB; 592329at2; -.
DR   UniPathway; UPA00254; UER00364.
DR   Proteomes; UP000008152; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016990; F:arginine deiminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019547; P:arginine catabolic process to ornithine; IEA:UniProtKB-UniPathway.
DR   GO; GO:0018101; P:protein citrullination; IEA:GOC.
DR   HAMAP; MF_00242; Arg_deiminase; 1.
DR   InterPro; IPR003876; Arg_deiminase.
DR   PIRSF; PIRSF006356; Arg_deiminase; 1.
DR   PRINTS; PR01466; ARGDEIMINASE.
DR   TIGRFAMs; TIGR01078; arcA; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism; Cytoplasm; Hydrolase.
FT   CHAIN           1..406
FT                   /note="Arginine deiminase"
FT                   /id="PRO_1000005731"
FT   ACT_SITE        396
FT                   /note="Amidino-cysteine intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00242"
SQ   SEQUENCE   406 AA;  45713 MW;  275AF17E7D99EB9D CRC64;
     MSKLYVGSEV GQLRRVLLNR PERALTHLTP SNCHELLFDD VLAVEAAGEE HDAFARTLRE
     QDVEVLLLHD LLVETLAVPE AKQWLLNTQI SDFRYGPTFA RDLRQYFAEM DDEHLASILL
     GGLAYSELPI KSSSMLPKMK RPLDFVIEPL PNHLFTRDTS CWVYGGVSLN PMMMPARQRE
     TNHLRAIYRW HPTFAGQDFI NYFGDEDQHY DNANVEGGDV LVIGKGAVLI GMSERTTPQG
     VENLAASLFK SGQAKEVIAI DLPKHRSCMH LDTVMTHMDV DTFSVYPEIM RKDLDTWRLT
     PKGNGEMHVE ASHNYLHAIE SALGLDQLKI ITTGGDSYEA EREQWNDANN VLTVKPGVVI
     GYERNVYTNE KYDKAGIEVL TIPGNELGRG RGGARCMSCP IERDDI