ID   L1103_FRATN             Reviewed;         282 AA.
AC   A0Q6X4;
DT   11-MAY-2016, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Bacterial lipoprotein FTN_1103;
DE            Short=BLP {ECO:0000303|PubMed:23584588};
DE   Flags: Precursor;
GN   OrderedLocusNames=FTN_1103;
OS   Francisella tularensis subsp. novicida (strain U112).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC   Francisellaceae; Francisella.
OX   NCBI_TaxID=401614;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=U112;
RX   PubMed=17550600; DOI=10.1186/gb-2007-8-6-r102;
RA   Rohmer L., Fong C., Abmayr S., Wasnick M., Larson Freeman T.J., Radey M.,
RA   Guina T., Svensson K., Hayden H.S., Jacobs M., Gallagher L.A., Manoil C.,
RA   Ernst R.K., Drees B., Buckley D., Haugen E., Bovee D., Zhou Y., Chang J.,
RA   Levy R., Lim R., Gillett W., Guenthener D., Kang A., Shaffer S.A.,
RA   Taylor G., Chen J., Gallis B., D'Argenio D.A., Forsman M., Olson M.V.,
RA   Goodlett D.R., Kaul R., Miller S.I., Brittnacher M.J.;
RT   "Comparison of Francisella tularensis genomes reveals evolutionary events
RT   associated with the emergence of human pathogenic strains.";
RL   Genome Biol. 8:R102.1-R102.16(2007).
RN   [2]
RP   FUNCTION IN VIRULENCE, INDUCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=U112;
RX   PubMed=23584588; DOI=10.1038/nature12048;
RA   Sampson T.R., Saroj S.D., Llewellyn A.C., Tzeng Y.L., Weiss D.S.;
RT   "A CRISPR/Cas system mediates bacterial innate immune evasion and
RT   virulence.";
RL   Nature 497:254-257(2013).
RN   [3]
RP   ERRATUM OF PUBMED:23584588.
RX   DOI=10.1038/nature12498;
RA   Sampson T.R., Saroj S.D., Llewellyn A.C., Tzeng Y.L., Weiss D.S.;
RL   Nature 501:602-602(2013).
CC   -!- FUNCTION: Stimulates the host immune inflammatory signaling system
CC       allowing the host to combat the bacteria. Stimulates mouse interleukin-
CC       6 (Il6) production (PubMed:23584588). {ECO:0000269|PubMed:23584588}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC       ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC   -!- INDUCTION: During infection of mouse bone marrow-derived macrophages
CC       (BMDM) expression decreases when the bacteria is expected to be in the
CC       phagosome. Disruption of genes for cas9 or either of its associated
CC       tracrRNA or scaRNA increases transcript levels about 100-fold both in
CC       culture and in mouse BMDM. {ECO:0000269|PubMed:23584588}.
CC   -!- DISRUPTION PHENOTYPE: Significantly decreases interleukin-6 (Il6)
CC       production in a Tlr2-dependent fashion by C57BL/6 mouse BMDM.
CC       {ECO:0000269|PubMed:23584588}.
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DR   EMBL; CP000439; ABK89989.1; -; Genomic_DNA.
DR   RefSeq; WP_003039722.1; NZ_CP009633.1.
DR   AlphaFoldDB; A0Q6X4; -.
DR   EnsemblBacteria; ABK89989; ABK89989; FTN_1103.
DR   KEGG; ftn:FTN_1103; -.
DR   OMA; KIQCDPG; -.
DR   OrthoDB; 843171at2; -.
DR   BioCyc; FTUL401614:G1G75-1145-MON; -.
DR   Proteomes; UP000000762; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR021699; DUF3281.
DR   Pfam; PF11685; DUF3281; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Signal; Virulence.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           29..282
FT                   /note="Bacterial lipoprotein FTN_1103"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT                   /id="PRO_0000436107"
FT   LIPID           29
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           29
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ   SEQUENCE   282 AA;  30599 MW;  732E506C3E3F7C52 CRC64;
     MKYGNLMMTK KKLLIGMVTI SGIVILGSCG KTETVNELLI VDQCNDVRDL CRLELANAQV
     SRYTNFLGKT IKRLQSQTPL RDIQGTVTWN ASAGTSLADN SDVQSELGLS CQDDNCTANS
     NSTAYTLPVG SNTISVSGTV TVDGKTIDLA TDVPALVINT SAAGSSVHVF PTELEGNLTL
     QDLVDSLNQG RHYAHATFSA DGSNLKIQCD PGYVWLDDIN PEYGGQSSAA SARSVAMVSW
     VEELEEFRVD EFRFLHFDMS SLTLNGVRLG NHVFWEMGCW PT