L2CC_DROME
ID L2CC_DROME Reviewed; 276 AA.
AC P24156; Q0E8P3; Q9VIZ4;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 30-AUG-2005, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Protein l(2)37Cc;
GN Name=l(2)37Cc; ORFNames=CG10691;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=3092183; DOI=10.1093/nar/14.15.6169;
RA Eveleth D.D. Jr., Marsh J.L.;
RT "Sequence and expression of the Cc gene, a member of the dopa decarboxylase
RT gene cluster of Drosophila: possible translational regulation.";
RL Nucleic Acids Res. 14:6169-6183(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Required for larval metabolism or for the progression of the
CC larva into a pupa. {ECO:0000269|PubMed:3092183}.
CC -!- DEVELOPMENTAL STAGE: Expressed in early embryos, late embryos, late
CC third instar larvae and adults. {ECO:0000269|PubMed:3092183}.
CC -!- SIMILARITY: Belongs to the prohibitin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA27807.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; X04228; CAA27810.1; ALT_FRAME; mRNA.
DR EMBL; X04227; CAA27807.1; ALT_FRAME; Genomic_DNA.
DR EMBL; AE014134; AAN11026.1; -; Genomic_DNA.
DR EMBL; AY122111; AAM52623.1; -; mRNA.
DR PIR; C25511; C25511.
DR RefSeq; NP_001163012.2; NM_001169541.2.
DR RefSeq; NP_476607.2; NM_057259.6.
DR RefSeq; NP_724165.1; NM_165281.2.
DR AlphaFoldDB; P24156; -.
DR SMR; P24156; -.
DR BioGRID; 72039; 22.
DR IntAct; P24156; 18.
DR MINT; P24156; -.
DR STRING; 7227.FBpp0080707; -.
DR PaxDb; P24156; -.
DR PRIDE; P24156; -.
DR DNASU; 49168; -.
DR EnsemblMetazoa; FBtr0081164; FBpp0080707; FBgn0002031.
DR EnsemblMetazoa; FBtr0081165; FBpp0080708; FBgn0002031.
DR EnsemblMetazoa; FBtr0346428; FBpp0312093; FBgn0002031.
DR GeneID; 49168; -.
DR KEGG; dme:Dmel_CG10691; -.
DR FlyBase; FBgn0002031; l(2)37Cc.
DR VEuPathDB; VectorBase:FBgn0002031; -.
DR eggNOG; KOG3083; Eukaryota.
DR GeneTree; ENSGT00950000183070; -.
DR HOGENOM; CLU_047969_0_0_1; -.
DR InParanoid; P24156; -.
DR OMA; QKMQFVL; -.
DR OrthoDB; 1089994at2759; -.
DR PhylomeDB; P24156; -.
DR Reactome; R-DME-5673000; RAF activation.
DR Reactome; R-DME-8949664; Processing of SMDT1.
DR SignaLink; P24156; -.
DR BioGRID-ORCS; 49168; 0 hits in 1 CRISPR screen.
DR ChiTaRS; l(2)37Cc; fly.
DR GenomeRNAi; 49168; -.
DR PRO; PR:P24156; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0002031; Expressed in embryonic/larval hemocyte (Drosophila) and 39 other tissues.
DR ExpressionAtlas; P24156; baseline and differential.
DR Genevisible; P24156; DM.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005739; C:mitochondrion; HDA:FlyBase.
DR GO; GO:0071456; P:cellular response to hypoxia; IMP:FlyBase.
DR GO; GO:0007005; P:mitochondrion organization; IBA:GO_Central.
DR CDD; cd03401; SPFH_prohibitin; 1.
DR Gene3D; 3.30.479.30; -; 1.
DR InterPro; IPR001107; Band_7.
DR InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR InterPro; IPR000163; Prohibitin.
DR PANTHER; PTHR23222; PTHR23222; 1.
DR Pfam; PF01145; Band_7; 1.
DR PRINTS; PR00679; PROHIBITIN.
DR SMART; SM00244; PHB; 1.
DR SUPFAM; SSF117892; SSF117892; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Reference proteome.
FT CHAIN 1..276
FT /note="Protein l(2)37Cc"
FT /id="PRO_0000213881"
FT CONFLICT 78
FT /note="V -> E (in Ref. 1; CAA27807/CAA27810)"
FT /evidence="ECO:0000305"
FT CONFLICT 125..143
FT /note="Missing (in Ref. 1; CAA27807/CAA27810)"
FT /evidence="ECO:0000305"
FT CONFLICT 220..252
FT /note="AAGLLAKSFGEAGDGLVELRRIEAAEDIAYQLS -> RACVGQVIARPETVW
FT WSLRLIDRPRYRLTSYP (in Ref. 1; CAA27807/CAA27810)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 276 AA; 30384 MW; EFE1CDB98A79F94F CRC64;
MAAQFFNRIG QMGLGVAVLG GVVNSALYNV EGGHRAVIFD RFTGIKENVV GEGTHFFIPW
VQRPIIFDIR SQPRNVPVIT GSKDLQNVNI TLRILYRPIP DQLPKIYTIL GQDYDERVLP
SIAPEVLKAV VAQFDAGELI TQREMVSQRV SQELTVRAKQ FGFILDDISL THLTFGREFT
LAVEMKQVAQ QEAEKARFVV EKAEQQKLAS IISAEGDAEA AGLLAKSFGE AGDGLVELRR
IEAAEDIAYQ LSRSRGVAYL PSGQSTLLNL PSTIAQ
