L2GL2_DANRE
ID L2GL2_DANRE Reviewed; 1020 AA.
AC Q7SZE3;
DT 18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=LLGL scribble cell polarity complex component 2;
DE AltName: Full=Lethal(2) giant larvae protein homolog 2;
DE AltName: Full=Protein penner;
GN Name=llgl2; Synonyms=pen;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION OF PENNER AS LLGL2, FUNCTION IN HEMIDESMOSOME,
RP PHOSPHORYLATION, CHARACTERIZATION, AND DISRUPTION PHENOTYPE.
RX PubMed=15983403; DOI=10.1242/dev.01904;
RA Sonawane M., Carpio Y., Geisler R., Schwarz H., Maischein H.M.,
RA Nuesslein-Volhard C.;
RT "Zebrafish penner/lethal giant larvae 2 functions in hemidesmosome
RT formation, maintenance of cellular morphology and growth regulation in the
RT developing basal epidermis.";
RL Development 132:3255-3265(2005).
CC -!- FUNCTION: Essential for hemidesmosome formation and maintenance of the
CC cytoskeleton elements as well as cellular morphology in the basal
CC epidermis during development. Also involved in regulating growth of the
CC basal epidermis. {ECO:0000269|PubMed:15983403}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC -!- PTM: Phosphorylated. {ECO:0000269|PubMed:15983403}.
CC -!- DISRUPTION PHENOTYPE: In larvae, basal epidermal cells migrate to
CC ectopic places and hyper-proliferate. {ECO:0000269|PubMed:15983403}.
CC -!- SIMILARITY: Belongs to the WD repeat L(2)GL family. {ECO:0000305}.
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DR EMBL; BC052919; AAH52919.1; -; mRNA.
DR RefSeq; NP_997747.1; NM_212582.1.
DR AlphaFoldDB; Q7SZE3; -.
DR SMR; Q7SZE3; -.
DR STRING; 7955.ENSDARP00000035593; -.
DR PaxDb; Q7SZE3; -.
DR Ensembl; ENSDART00000034550; ENSDARP00000035593; ENSDARG00000023920.
DR Ensembl; ENSDART00000189849; ENSDARP00000148707; ENSDARG00000023920.
DR GeneID; 795670; -.
DR KEGG; dre:795670; -.
DR CTD; 3993; -.
DR ZFIN; ZDB-GENE-030131-9877; llgl2.
DR eggNOG; KOG1983; Eukaryota.
DR GeneTree; ENSGT00950000182906; -.
DR HOGENOM; CLU_005214_0_0_1; -.
DR InParanoid; Q7SZE3; -.
DR OMA; QWPVSGD; -.
DR OrthoDB; 122541at2759; -.
DR PhylomeDB; Q7SZE3; -.
DR TreeFam; TF314585; -.
DR PRO; PR:Q7SZE3; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 12.
DR Bgee; ENSDARG00000023920; Expressed in cleaving embryo and 56 other tissues.
DR ExpressionAtlas; Q7SZE3; baseline.
DR GO; GO:0030864; C:cortical actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0045159; F:myosin II binding; IBA:GO_Central.
DR GO; GO:0030031; P:cell projection assembly; IMP:ZFIN.
DR GO; GO:0030866; P:cortical actin cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0007010; P:cytoskeleton organization; IMP:ZFIN.
DR GO; GO:0008544; P:epidermis development; IMP:ZFIN.
DR GO; GO:0051294; P:establishment of spindle orientation; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR GO; GO:0031581; P:hemidesmosome assembly; IMP:ZFIN.
DR GO; GO:0070121; P:Kupffer's vesicle development; IMP:ZFIN.
DR GO; GO:0044458; P:motile cilium assembly; IMP:ZFIN.
DR GO; GO:0030336; P:negative regulation of cell migration; IMP:ZFIN.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IMP:ZFIN.
DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IMP:ZFIN.
DR GO; GO:0010719; P:negative regulation of epithelial to mesenchymal transition; IMP:ZFIN.
DR GO; GO:0008594; P:photoreceptor cell morphogenesis; IMP:ZFIN.
DR GO; GO:0048919; P:posterior lateral line neuromast development; IMP:ZFIN.
DR GO; GO:0045682; P:regulation of epidermis development; IGI:ZFIN.
DR GO; GO:0032878; P:regulation of establishment or maintenance of cell polarity; IBA:GO_Central.
DR GO; GO:0008593; P:regulation of Notch signaling pathway; IBA:GO_Central.
DR GO; GO:0050708; P:regulation of protein secretion; IBA:GO_Central.
DR GO; GO:0043588; P:skin development; IMP:ZFIN.
DR GO; GO:0098773; P:skin epidermis development; IGI:ZFIN.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR000664; Lethal2_giant.
DR InterPro; IPR013577; LLGL2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF08366; LLGL; 1.
DR PRINTS; PR00962; LETHAL2GIANT.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; SSF50978; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cytoplasm; Cytoskeleton; Exocytosis; Phosphoprotein;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..1020
FT /note="LLGL scribble cell polarity complex component 2"
FT /id="PRO_0000232731"
FT REPEAT 36..69
FT /note="WD 1"
FT REPEAT 76..117
FT /note="WD 2"
FT REPEAT 132..169
FT /note="WD 3"
FT REPEAT 193..227
FT /note="WD 4"
FT REPEAT 233..264
FT /note="WD 5"
FT REPEAT 282..324
FT /note="WD 6"
FT REPEAT 332..364
FT /note="WD 7"
FT REPEAT 386..462
FT /note="WD 8"
FT REPEAT 506..581
FT /note="WD 9"
FT REPEAT 590..651
FT /note="WD 10"
FT REPEAT 710..766
FT /note="WD 11"
FT REPEAT 775..827
FT /note="WD 12"
FT REPEAT 832..884
FT /note="WD 13"
FT REPEAT 898..921
FT /note="WD 14"
FT REGION 935..968
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 951..966
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1020 AA; 113844 MW; CB913A61155AC6B9 CRC64;
MKRFRRHGHE SQRDKHKQDL YQFNKTVEHG FPHQPSALGF SPSLELLAIG TRSGAIKLYG
APGVEFMGLH DENAAVTQVH FLPNQVELVT LLEDNSLHMW TLRAHNSMCE LLEIGRFTLS
GPPGAIPSVT RVTAVLAHSS GELLLLGTEG GHVFVVEVPG FRELEENNIS VEDVQNRVPE
DYVGRRNLES VETLHENPLN PRQVLIGYSR GLMVLWDLDR QRPVQHFLGT QQLESVWWME
DGESILSSHS DGSYCQWTVT GEDPQTEPEK QETPYGAFPC KAISKIIQLP SKQGPPFLIF
SGGMPRASYG DRHCISVIHS KTHEALDFTS RIIDFFVIRE GENHKGEPSA LVVLVEEELV
VVDLQTEGWP VIQTPYLVPL HCSAITCSHH VSSIPLKLWE RVQAAGAHQN THYSRKPWPI
NGGKNLAPDP PQRDLLLTGH EDGTVRFWDA SGVCLYPMYK LSTAGVFHTD ADPNDNMNQG
SEGEWPPFRK VGCFDPYSDD PRLGIQKIHL CKYSGYLTVA GTAGQILVLE LNDEAAEQMV
EATVVDLLQG QEGFRWKGQA RLDVREEPVL FPPGFQPFAL VQCQPPAVVT AIALHSEWKL
VGFGTSHGFG LYDYNQRNNI MVKCTLNPSD QMAMEGPLSR VKSIKKSLRQ SFRRIRRSRV
SMRKHHTNNA AKLQEINARL EAEALQEMEL APVQRKIEAR SSDDSFTGLV RTLYFADTFV
SDSSHSTPSL WAGTNGGAVF AYVLRVPPQE RRAEDPVTAH AAKEIQLMHR APVVGLVVLD
GKGAPLPEPL EVAHDLARSP EMHGSHHLLV VSEEQFKLFT LPKVSSKSKL KLTAVDGSRV
RRVGVAWFGS RTDEQLESCL VVLTNQGELH VISLPSIKML VHYPCIRRED VSGIASCVFT
KYGQGFYLIS PSEFERFSLS TRWVVQPHCL VEPPLQMRSK SPSSPVHRDL PDGVPTEHRN
FKGDSEGYEN SARQVMEHAL LNDESVLQEI QKSLEGDQTT FLENNLKTKP KAGNVLSNGD
