L2GL2_PONAB
ID L2GL2_PONAB Reviewed; 1019 AA.
AC Q5RCX2;
DT 18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=LLGL scribble cell polarity complex component 2;
DE AltName: Full=Lethal(2) giant larvae protein homolog 2;
GN Name=LLGL2;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-
CC 6, which may ensure the correct organization and orientation of bipolar
CC spindles for normal cell division. This complex plays roles in the
CC initial phase of the establishment of epithelial cell polarity (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6. The
CC complex is enhanced during mitosis. Interacts with DCAF1 (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Localized in the
CC perinuclear structure and faintly at the cell-cell contacts sites in
CC the interphase. Localized at the cell periphery during metaphase.
CC Cortical localization in mitotic cells (By similarity). {ECO:0000250}.
CC -!- PTM: Phosphorylated at Ser-653 by PRKCI. Phosphorylation is enhanced
CC during cell polarization induced by calcium. Phosphorylation may occur
CC during the cell-cell contact-induced cell polarization and may
CC contribute to the segregation of LLGL2 from the PRKCI/aPKC and
CC PARD6B/Par-6 complex (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat L(2)GL family. {ECO:0000305}.
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DR EMBL; CR858146; CAH90385.1; -; mRNA.
DR RefSeq; NP_001127280.1; NM_001133808.1.
DR AlphaFoldDB; Q5RCX2; -.
DR SMR; Q5RCX2; -.
DR STRING; 9601.ENSPPYP00000009692; -.
DR PRIDE; Q5RCX2; -.
DR GeneID; 100174337; -.
DR KEGG; pon:100174337; -.
DR CTD; 3993; -.
DR eggNOG; KOG1983; Eukaryota.
DR InParanoid; Q5RCX2; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR000664; Lethal2_giant.
DR InterPro; IPR013577; LLGL2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF08366; LLGL; 1.
DR PRINTS; PR00962; LETHAL2GIANT.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Cell division; Cytoplasm; Exocytosis; Phosphoprotein;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..1019
FT /note="LLGL scribble cell polarity complex component 2"
FT /id="PRO_0000232730"
FT REPEAT 36..69
FT /note="WD 1"
FT REPEAT 76..117
FT /note="WD 2"
FT REPEAT 132..169
FT /note="WD 3"
FT REPEAT 193..227
FT /note="WD 4"
FT REPEAT 233..268
FT /note="WD 5"
FT REPEAT 282..324
FT /note="WD 6"
FT REPEAT 332..366
FT /note="WD 7"
FT REPEAT 388..464
FT /note="WD 8"
FT REPEAT 508..583
FT /note="WD 9"
FT REPEAT 592..653
FT /note="WD 10"
FT REPEAT 713..769
FT /note="WD 11"
FT REPEAT 778..830
FT /note="WD 12"
FT REPEAT 835..888
FT /note="WD 13"
FT REPEAT 902..925
FT /note="WD 14"
FT REGION 647..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 939..975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 992..1019
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 648..666
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 653
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6P1M3"
FT MOD_RES 965
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6P1M3"
SQ SEQUENCE 1019 AA; 113582 MW; 3CAA26AE358F5469 CRC64;
MRRFLRPGHD PVRERLKRDL FQFNKTVEHG FPHQPSALGY SPSLRILAIG TRSGAIKLYG
APGVEFMGLH RENNAVTQIH LLPGQCQLVT LLDDNSLHLW SLKVKGGASE LQEDESFTLR
GPPGAAPSAT QITVVLPHSS CELLYLGTES GNVFVVQLPA FRALEDRTIS SDAVLQRLPE
EARHRRVFEM VEALQEHPRD PNQILIGYSR GLVVIWDLQG SRVLYHFLSS QQLENIWWQR
DGRLLVSCHS DGSYCQWPMS SEAQQPEPLR SLVPYGPFPC KAITKILWLT TRQGLPFTIF
QGGMPRASYG DRHCTSVIHD GQQTAFDFTS RVIDFTVLTE ADPAAAFDDP YALVVLAEEE
LVVIDLQTAG WPPVQLPYLA SLHCSAITCS HHVSNIPLKL WERIIAAGSR QNAHFSTMEW
PIDGGTSLTP APPQRDLLLT GHEDGTVRFW DASGVCLRLL YKLSTVRVFL TDTDPNENLS
AHGEDEWPPL RKVGSFDPYS DDPRLGIQKI FLCKYSGYLA VAGTAGQVLV LELNDEAAEQ
AVEQVEADLL QDQEGYRWKG HERLAAHSGP VRFEPGFQPF VLVQCQPPAV VTSLALHSEW
RLVAFGTSHG FGLFDHQQRR QVFVKCTLHP SDQLALEGPL SRVKSLKKSL RQSFRRMRRS
RVSSRKRRPA GPPGEVQEGS VKAERPGLQN MELAPVQRKI EARSVEDSFT GFVRTLYFAD
TYLRDSSRHC PSLWAGTNGG TIYAFSLRVP PAERRMDETV RAEQAKEIQL MHRAPVVGIL
VLDGHSVPLP EPLEVAHDLS KSPDMPGSHQ LLVVSEEQFK VFTLPKVSAK LKLKLTALEG
SRVRRVSVAH FGSRRAEDYG EHHLAVLTNL GDIQVVSLPL LKPQVRYSCI RREDVSGIAS
CVFTKYGQGF YLISPSEFER FSLSTKWLVE PRCLVDSAET KNHRPGNGAG PKKAPSRVRN
SGTQSDGEEK QPGLVMERAL LSDERVLKEI QSTLEGDRGS RNWRSHRAAV GCSLGNGGE
