ID   L2HDH_CAEEL             Reviewed;         433 AA.
AC   Q9N4Z0;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 2.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=L-2-hydroxyglutarate dehydrogenase, mitochondrial;
DE            EC=1.1.99.2;
DE   Flags: Precursor;
GN   ORFNames=Y45G12B.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2;
CC         Xref=Rhea:RHEA:21252, ChEBI:CHEBI:13193, ChEBI:CHEBI:16782,
CC         ChEBI:CHEBI:16810, ChEBI:CHEBI:17499; EC=1.1.99.2;
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the L2HGDH family. {ECO:0000305}.
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DR   EMBL; FO080651; CCD65497.1; -; Genomic_DNA.
DR   RefSeq; NP_503730.1; NM_071329.3.
DR   AlphaFoldDB; Q9N4Z0; -.
DR   SMR; Q9N4Z0; -.
DR   BioGRID; 43790; 1.
DR   STRING; 6239.Y45G12B.3; -.
DR   EPD; Q9N4Z0; -.
DR   PaxDb; Q9N4Z0; -.
DR   PeptideAtlas; Q9N4Z0; -.
DR   EnsemblMetazoa; Y45G12B.3a.1; Y45G12B.3a.1; WBGene00021564.
DR   EnsemblMetazoa; Y45G12B.3a.2; Y45G12B.3a.2; WBGene00021564.
DR   GeneID; 178733; -.
DR   KEGG; cel:CELE_Y45G12B.3; -.
DR   UCSC; Y45G12B.3; c. elegans.
DR   CTD; 178733; -.
DR   WormBase; Y45G12B.3a; CE28366; WBGene00021564; -.
DR   eggNOG; KOG2665; Eukaryota.
DR   GeneTree; ENSGT00490000043421; -.
DR   HOGENOM; CLU_024775_0_0_1; -.
DR   InParanoid; Q9N4Z0; -.
DR   OMA; GVHFTRM; -.
DR   OrthoDB; 1310154at2759; -.
DR   PhylomeDB; Q9N4Z0; -.
DR   Reactome; R-CEL-880009; Interconversion of 2-oxoglutarate and 2-hydroxyglutarate.
DR   PRO; PR:Q9N4Z0; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00021564; Expressed in adult organism and 4 other tissues.
DR   ExpressionAtlas; Q9N4Z0; baseline and differential.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0003973; F:(S)-2-hydroxy-acid oxidase activity; IBA:GO_Central.
DR   GO; GO:0047545; F:2-hydroxyglutarate dehydrogenase activity; IBA:GO_Central.
DR   Gene3D; 3.50.50.60; -; 1.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   Pfam; PF01266; DAO; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Mitochondrion; Oxidoreductase; Reference proteome;
KW   Transit peptide.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..433
FT                   /note="L-2-hydroxyglutarate dehydrogenase, mitochondrial"
FT                   /id="PRO_0000331211"
SQ   SEQUENCE   433 AA;  47901 MW;  2565A7A72A5582BA CRC64;
     MLNRGTFQVF RGISGPPKKS VDLPKYDLVI VGGGIVGCAT ARQLLIEKPQ LKVALIEKEK
     ELAVHQSGHN SGVIHAGIYY TPGSLKAKLC VEGLDLSYEF FDKEKVPYKK TGKLIVAVEP
     EEVPRLDALF SRAQTNGCRD IEMIDSSKIT ELEPHCRGLK ALWSPHTGIV DWGYVTKRFG
     EDFEKRGGKI YTSYPLEKIS DNHDPGYPIR VSSGPALAEF ETKNLITCAG LQSDRVAALS
     GCSTDPKIVP FRGEYLLLKP EKRHLVKTNI YPVPDPRFPF LGVHFTPRMN GDIWLGPNAV
     LAYKREGYSY FSISPSDLLE SLSYSGMQKL VKKHFTFGIK ELYRGVWIAA QVKQLQRFIP
     ELKLSDVTRG PAGVRAQAMD SAGNLVDDFV FDSGTGKLSP LLMHVRNAPS PAATSSLAIA
     KMITSEAINR FKL