ID   L2HDH_PONAB             Reviewed;         419 AA.
AC   Q5R9N7;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=L-2-hydroxyglutarate dehydrogenase, mitochondrial;
DE            Short=Duranin;
DE            EC=1.1.99.2;
DE   Flags: Precursor;
GN   Name=L2HGDH;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2;
CC         Xref=Rhea:RHEA:21252, ChEBI:CHEBI:13193, ChEBI:CHEBI:16782,
CC         ChEBI:CHEBI:16810, ChEBI:CHEBI:17499; EC=1.1.99.2;
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the L2HGDH family. {ECO:0000305}.
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DR   EMBL; CR859349; CAH91523.1; -; mRNA.
DR   RefSeq; NP_001125894.1; NM_001132422.1.
DR   AlphaFoldDB; Q5R9N7; -.
DR   SMR; Q5R9N7; -.
DR   GeneID; 100172827; -.
DR   KEGG; pon:100172827; -.
DR   CTD; 79944; -.
DR   InParanoid; Q5R9N7; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0047545; F:2-hydroxyglutarate dehydrogenase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.50.50.60; -; 1.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   Pfam; PF01266; DAO; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; FAD; Flavoprotein; Mitochondrion; Oxidoreductase;
KW   Reference proteome; Transit peptide.
FT   TRANSIT         1..51
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           52..419
FT                   /note="L-2-hydroxyglutarate dehydrogenase, mitochondrial"
FT                   /id="PRO_0000228131"
FT   MOD_RES         104
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q91YP0"
FT   MOD_RES         173
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q91YP0"
SQ   SEQUENCE   419 AA;  45538 MW;  CB1D46E465CAC0A6 CRC64;
     MVPALRYLVG ACGRARGGFA GDFPGASGLA SGRPRPLCGG SRSASTSSFD IVIVGGGIVG
     LASARALILR HPSLSIGVLE KEKDLAVHQT GHNSGVIHSG IYYKPESLKA KLCVQGAALL
     YEYCQQKGIS YKQCGKLIVA VEQEEIPRLQ ALYERGLQNG VQGLRLIQQD DIKKKEPYCR
     GLMAIDCPHT GIVDYRQVAL SFAQDFQDAG GSVLTNFEVK DIEMAKESLS RSIDGMQYPI
     VIKNIKGEEI RCQYVVTCAG LYSDRISELS GCSPDPRIVS FRGDYLLLKP EKCYLVKGNI
     YPVPDSRFPF LGVHFTLRMD GSIWLGPNAV LAFKREGYRP FDFSATDVMD IIINRGPAGV
     RAQALDRDGN LVDDFVFDAG VGDIGNRILH VRNAPSPAAT SSIAISGMIA DEVQQRFEL