ID   L2K1_DROME              Reviewed;         221 AA.
AC   Q9V574; P91662;
DT   19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 2.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Protein lethal(2)k10201;
DE   AltName: Full=Wunen region B protein;
GN   Name=l(2)k10201; ORFNames=CG13951;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000312|EMBL:AAF58944.2};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=8985246; DOI=10.1038/385064a0;
RA   Zhang N., Zhang J.P., Purcell K.J., Chen Y., Howard K.;
RT   "The Drosophila protein Wunen repels migrating germ cells.";
RL   Nature 385:64-67(1997).
RN   [2] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3] {ECO:0000305}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC   -!- FUNCTION: Vital for development. {ECO:0000269|PubMed:8985246}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC47450.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; U73823; AAC47450.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AE013599; AAF58944.2; -; Genomic_DNA.
DR   RefSeq; NP_788296.1; NM_176116.3.
DR   AlphaFoldDB; Q9V574; -.
DR   BioGRID; 71352; 8.
DR   DIP; DIP-19602N; -.
DR   IntAct; Q9V574; 8.
DR   STRING; 7227.FBpp0087589; -.
DR   PaxDb; Q9V574; -.
DR   PRIDE; Q9V574; -.
DR   EnsemblMetazoa; FBtr0088505; FBpp0087589; FBgn0016970.
DR   GeneID; 48373; -.
DR   KEGG; dme:Dmel_CG13951; -.
DR   FlyBase; FBgn0016970; l(2)k10201.
DR   VEuPathDB; VectorBase:FBgn0016970; -.
DR   eggNOG; KOG4173; Eukaryota.
DR   GeneTree; ENSGT00390000011381; -.
DR   HOGENOM; CLU_092647_1_0_1; -.
DR   InParanoid; Q9V574; -.
DR   OMA; YRFDQGK; -.
DR   OrthoDB; 1360267at2759; -.
DR   PhylomeDB; Q9V574; -.
DR   BioGRID-ORCS; 48373; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 48373; -.
DR   PRO; PR:Q9V574; -.
DR   Proteomes; UP000000803; Chromosome 2R.
DR   Bgee; FBgn0016970; Expressed in secondary oocyte and 22 other tissues.
DR   ExpressionAtlas; Q9V574; baseline and differential.
DR   Genevisible; Q9V574; DM.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR039258; ZNF511.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR21354; PTHR21354; 1.
DR   SMART; SM00355; ZnF_C2H2; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
PE   4: Predicted;
KW   Developmental protein; Metal-binding; Reference proteome; Repeat; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..221
FT                   /note="Protein lethal(2)k10201"
FT                   /id="PRO_0000046927"
FT   ZN_FING         74..97
FT                   /note="C2H2-type 1"
FT   ZN_FING         113..138
FT                   /note="C2H2-type 2"
FT   REGION          146..168
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   221 AA;  24962 MW;  CC906EC62398DAD9 CRC64;
     MDSEAAGVAL LSREQIIRIL SEVPAGFIKP TDPPAPSLAP FKKLGVLVDI DDILGEQDAA
     AARIRDNIDK EQSYSCVECR KMLPTAHLLD LHITEQHDCY FAASVERGDK PMFSCFLEEC
     TIKFHTARQR KDHCIITHKL PANYRFDHSK NRGKQKHQGK SKPNSMEVDE VIEETKSLPY
     VKAFSFGHQT QRSFYTGKDQ RSGKTLDDVQ AMKEAINDIL D