ID   L2MU_ADE12              Reviewed;          72 AA.
AC   P35986;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   23-FEB-2022, entry version 70.
DE   RecName: Full=Late L2 mu core protein;
DE   AltName: Full=11 kDa core protein;
DE   AltName: Full=Protein X;
DE            Short=pX;
DE   AltName: Full=pMu;
DE   Flags: Precursor;
GN   Name=PX;
OS   Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus; Human mastadenovirus A.
OX   NCBI_TaxID=28282;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 28-42.
RC   STRAIN=Huie;
RX   PubMed=8438575; DOI=10.1006/viro.1993.1131;
RA   Freimuth P., Anderson C.W.;
RT   "Human adenovirus serotype 12 virion precursors pMu and pVI are cleaved at
RT   amino-terminal and carboxy-terminal sites that conform to the adenovirus 2
RT   endoproteinase cleavage consensus sequence.";
RL   Virology 193:348-355(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8254750; DOI=10.1128/jvi.68.1.379-389.1994;
RA   Sprengel J., Schmitz B., Heuss-Neitzel D., Zock C., Doerfler W.;
RT   "Nucleotide sequence of human adenovirus type 12 DNA: comparative
RT   functional analysis.";
RL   J. Virol. 68:379-389(1994).
CC   -!- FUNCTION: The role of the precursor might be to condense the viral
CC       prochromatin for encapsidation by virtue of the two basic domains.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the adenoviridae pX family. {ECO:0000305}.
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DR   EMBL; L02237; AAA42515.1; -; Genomic_DNA.
DR   EMBL; X73487; CAA51889.1; -; Genomic_DNA.
DR   PIR; A45393; A45393.
DR   RefSeq; NP_040922.1; NC_001460.1.
DR   GeneID; 1460868; -.
DR   Proteomes; UP000004993; Genome.
DR   GO; GO:0019013; C:viral nucleocapsid; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR008393; Adenovirus_late_L2_mu_core.
DR   Pfam; PF05829; Adeno_PX; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; DNA-binding; Late protein; Virion.
FT   INIT_MET        1
FT                   /note="Removed; by host"
FT                   /evidence="ECO:0000250"
FT   PROPEP          2..27
FT                   /evidence="ECO:0000269|PubMed:8438575"
FT                   /id="PRO_0000036522"
FT   PEPTIDE         28..42
FT                   /note="Late L2 mu core protein"
FT                   /id="PRO_0000036523"
FT   PROPEP          43..72
FT                   /id="PRO_0000036524"
FT   SITE            27..28
FT                   /note="Cleavage; by adenovirus protease"
FT   SITE            42..43
FT                   /note="Cleavage; by adenovirus protease"
SQ   SEQUENCE   72 AA;  7971 MW;  AB56A59BB2327B3F CRC64;
     MALTCRMRIP IPGYRGRPRR RKGLTGNGRF RRRSMRRRMK GGVLPFLIPL IAAAIGAVPG
     IASVALQASR KN