ID   L2_VACCW                Reviewed;          87 AA.
AC   P07613; Q80HW7;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 2.
DT   23-FEB-2022, entry version 61.
DE   RecName: Full=Protein L2;
DE   AltName: Full=Protein F3;
GN   OrderedLocusNames=VACWR089; ORFNames=L2R;
OS   Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
OS   WR)).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10254;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2987815; DOI=10.1093/nar/13.3.985;
RA   Plucienniczak A., Schroeder E., Zettlmeissl G., Streeck R.E.;
RT   "Nucleotide sequence of a cluster of early and late genes in a conserved
RT   segment of the vaccinia virus genome.";
RL   Nucleic Acids Res. 13:985-998(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J.,
RA   Wohlhueter R.;
RT   "Sequencing of the coding region of Vaccinia-WR to an average 9-fold
RT   redundancy and an error rate of 0.16/10kb.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION, AND INDUCTION.
RX   PubMed=21228235; DOI=10.1128/jvi.02505-10;
RA   Maruri-Avidal L., Domi A., Weisberg A.S., Moss B.;
RT   "Participation of vaccinia virus l2 protein in the formation of crescent
RT   membranes and immature virions.";
RL   J. Virol. 85:2504-2511(2011).
CC   -!- FUNCTION: Early protein involved in early virion morphogenesis.
CC       Participates in the formation and elongation of crescent-shaped
CC       membrane precursors of immature virions in cytoplasmic factories.
CC       {ECO:0000269|PubMed:21228235}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}. Host cytoplasm. Note=Localizes in
CC       cytoplasmic virus factories.
CC   -!- INDUCTION: Expressed in the early phase of the viral replicative cycle.
CC       {ECO:0000269|PubMed:21228235}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae L2 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA26011.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; X01978; CAA26011.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AY243312; AAO89368.1; -; Genomic_DNA.
DR   PIR; C23092; QQVZF3.
DR   RefSeq; YP_232971.1; NC_006998.1.
DR   DNASU; 3707545; -.
DR   GeneID; 3707545; -.
DR   KEGG; vg:3707545; -.
DR   Proteomes; UP000000344; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008447; Prot_L2.
DR   Pfam; PF05803; Chordopox_L2; 1.
PE   2: Evidence at transcript level;
KW   Early protein; Host cytoplasm; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Virion.
FT   CHAIN           1..87
FT                   /note="Protein L2"
FT                   /id="PRO_0000099618"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   87 AA;  10255 MW;  36BA3CE254375E3F CRC64;
     MEVITDRLDD IVKQNIADEK FVDFVIHGLE HQCPAILRPL IRLFIDILLF VIVIYIFTVR
     LVSRNYQMLL ALVALVITLT IFYYFIL