L37A1_HUMAN
ID L37A1_HUMAN Reviewed; 1700 AA.
AC A6NMS7; Q68DY2; Q8IWC7;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 31-MAY-2011, sequence version 3.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Leucine-rich repeat-containing protein 37A;
DE Flags: Precursor;
GN Name=LRRC37A; Synonyms=LRRC37A1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the LRRC37A family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAH18088.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; CR749232; CAH18088.1; ALT_FRAME; mRNA.
DR EMBL; AC005829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC139026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC040501; AAH40501.2; -; mRNA.
DR CCDS; CCDS11504.2; -.
DR RefSeq; NP_055649.4; NM_014834.4.
DR AlphaFoldDB; A6NMS7; -.
DR SMR; A6NMS7; -.
DR BioGRID; 115215; 1.
DR IntAct; A6NMS7; 1.
DR STRING; 9606.ENSP00000326324; -.
DR GlyGen; A6NMS7; 2 sites.
DR iPTMnet; A6NMS7; -.
DR PhosphoSitePlus; A6NMS7; -.
DR BioMuta; LRRC37A; -.
DR MassIVE; A6NMS7; -.
DR PaxDb; A6NMS7; -.
DR PeptideAtlas; A6NMS7; -.
DR PRIDE; A6NMS7; -.
DR ProteomicsDB; 1558; -.
DR Antibodypedia; 67258; 20 antibodies from 8 providers.
DR DNASU; 9884; -.
DR Ensembl; ENST00000320254.5; ENSP00000326324.5; ENSG00000176681.14.
DR GeneID; 9884; -.
DR KEGG; hsa:9884; -.
DR MANE-Select; ENST00000320254.5; ENSP00000326324.5; NM_014834.4; NP_055649.4.
DR UCSC; uc002ikg.3; human.
DR CTD; 9884; -.
DR DisGeNET; 9884; -.
DR GeneCards; LRRC37A; -.
DR HGNC; HGNC:29069; LRRC37A.
DR HPA; ENSG00000176681; Tissue enhanced (testis).
DR MIM; 616555; gene.
DR neXtProt; NX_A6NMS7; -.
DR OpenTargets; ENSG00000176681; -.
DR VEuPathDB; HostDB:ENSG00000176681; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00530000063282; -.
DR InParanoid; A6NMS7; -.
DR OMA; TRSINIC; -.
DR OrthoDB; 181606at2759; -.
DR PhylomeDB; A6NMS7; -.
DR TreeFam; TF341959; -.
DR PathwayCommons; A6NMS7; -.
DR SignaLink; A6NMS7; -.
DR BioGRID-ORCS; 9884; 14 hits in 620 CRISPR screens.
DR ChiTaRS; LRRC37A; human.
DR GeneWiki; LRRC37A; -.
DR GenomeRNAi; 9884; -.
DR Pharos; A6NMS7; Tdark.
DR PRO; PR:A6NMS7; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; A6NMS7; protein.
DR Bgee; ENSG00000176681; Expressed in bone marrow cell and 98 other tissues.
DR ExpressionAtlas; A6NMS7; baseline and differential.
DR Genevisible; A6NMS7; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR015753; LRRC37.
DR InterPro; IPR032754; LRRC37_N.
DR InterPro; IPR029423; LRRC37AB_C.
DR PANTHER; PTHR23045; PTHR23045; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF15779; LRRC37; 7.
DR Pfam; PF14914; LRRC37AB_C; 1.
DR SMART; SM00369; LRR_TYP; 4.
DR PROSITE; PS51450; LRR; 4.
PE 2: Evidence at transcript level;
KW Glycoprotein; Leucine-rich repeat; Membrane; Reference proteome; Repeat;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..35
FT /evidence="ECO:0000255"
FT CHAIN 36..1700
FT /note="Leucine-rich repeat-containing protein 37A"
FT /id="PRO_0000337079"
FT TOPO_DOM 36..1582
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1583..1603
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1604..1700
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 866..887
FT /note="LRR 1"
FT REPEAT 890..911
FT /note="LRR 2"
FT REPEAT 914..935
FT /note="LRR 3"
FT REPEAT 938..959
FT /note="LRR 4"
FT REPEAT 965..986
FT /note="LRR 5"
FT REGION 54..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 130..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 169..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 559..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 619..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 685..708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 729..751
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 758..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1182..1227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1250..1271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1676..1700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..156
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..279
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..386
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..521
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 729..748
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1251..1265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 296
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1079
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 58
FT /note="E -> D (in Ref. 1; CAH18088 and 3; AAH40501)"
FT /evidence="ECO:0000305"
FT CONFLICT 349
FT /note="P -> S (in Ref. 1; CAH18088 and 3; AAH40501)"
FT /evidence="ECO:0000305"
FT CONFLICT 370
FT /note="P -> S (in Ref. 1; CAH18088 and 3; AAH40501)"
FT /evidence="ECO:0000305"
FT CONFLICT 377
FT /note="P -> L (in Ref. 1; CAH18088 and 3; AAH40501)"
FT /evidence="ECO:0000305"
FT CONFLICT 406
FT /note="A -> D (in Ref. 1; CAH18088 and 3; AAH40501)"
FT /evidence="ECO:0000305"
FT CONFLICT 440
FT /note="T -> A (in Ref. 1; CAH18088 and 3; AAH40501)"
FT /evidence="ECO:0000305"
FT CONFLICT 552
FT /note="T -> I (in Ref. 1; CAH18088)"
FT /evidence="ECO:0000305"
FT CONFLICT 558
FT /note="K -> M (in Ref. 1; CAH18088 and 3; AAH40501)"
FT /evidence="ECO:0000305"
FT CONFLICT 630
FT /note="P -> A (in Ref. 1; CAH18088 and 3; AAH40501)"
FT /evidence="ECO:0000305"
FT CONFLICT 776
FT /note="R -> H (in Ref. 1; CAH18088 and 3; AAH40501)"
FT /evidence="ECO:0000305"
FT CONFLICT 785
FT /note="R -> Q (in Ref. 1; CAH18088 and 3; AAH40501)"
FT /evidence="ECO:0000305"
FT CONFLICT 1255
FT /note="T -> A (in Ref. 1; CAH18088 and 3; AAH40501)"
FT /evidence="ECO:0000305"
FT CONFLICT 1288
FT /note="R -> G (in Ref. 1; CAH18088)"
FT /evidence="ECO:0000305"
FT CONFLICT 1384
FT /note="E -> G (in Ref. 3; AAH40501)"
FT /evidence="ECO:0000305"
FT CONFLICT 1693
FT /note="E -> G (in Ref. 3; AAH40501)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1700 AA; 188258 MW; F5DBA6389568D792 CRC64;
MSSAQCPALV CVMSRLRFWG PWPLLMWQLL WLLVKEAQPL EWVKDPLQLT SNPLGPPESW
SSHSSHFPRE SPHAPTLPAD PWDFDHLGPS ASSEMPAPPQ ESTENLVPFL DTWDSAGEQP
LEPEQFLASQ QDLKDKLSPQ ERLPVSPKKL KKDPAQRWSL AEIIGITRQL STPQSQKQTL
QNEYSSTDTP YPGSLPPELR VKSDEPPGPS EQVGPSQFHL EPETQNPETL EDIQSSSLQQ
EAPAQLPQLL EEEPSSMQQE APALPPESSM ESLTLPNHEV SVQPPGEDQA YYHLPNITVK
PADVEVTITS EPTNETESSQ AQQETPIQFP EEVEPSATQQ EAPIEPPVPP MEHELSISEQ
QQPVQPSESP REVESSPTQQ ETPGQPPEHH EVTVSPPGHH QTHHLASPSV SVKPPDVQLT
IAAEPSAEVG TSLVHQEATT RLSGSGNDVE PPAIQHGGPP LLPESSEEAG PLAVQQETSF
QSPEPINNEN PSPTQQEAAA EHPQTAEEGE SSLTHQEAPA QTPEFPNVVV AQPPEHSHLT
QATVQPLDLG FTITPESKTE VELSPTMKET PTQPPKKVVP QLRVYQGVTN PTPGQDQAQH
PVSPSVTVQL LDLGLTITPE PTTEVGHSTP PKRTIVSPKH PEVTLPHPDQ VQTQHSHLTR
ATVQPLDLGF TITPKSMTEV EPSTALMTTA PPPGHPEVTL PPSDKGQAQH SHLTQATVQP
LDLELTITTK PTTEVKPSPT TEETSTQPPD LGLAIIPEPT TETGHSTALE KTTAPRPDRV
QTLHRSLTEV TGPPTELEPA QDSLVQSESY TQNKALTAPE EHKASTSTNI CELCTCGDEM
LSCIDLNPEQ RLRQVPVPEP NTHNGTFTIL NFQGNYISYI DGNVWKAYSW TEKLILRENN
LTELHKDSFE GLLSLQYLDL SCNKIQSIER HTFEPLPFLK FINLSCNVIT ELSFGTFQAW
HGMQFLHKLI LNHNPLTTVE DPYLFKLPAL KYLDMGTTLV PLTTLKNILM MTVELEKLIL
PSHMACCLCQ FKNSIEAVCK TVKLHCNSAC LTNTTHCPEE ASVGNPEGAF MKVLQARKNY
TSTELIVEPE EPSDSSGINL SGFGSEQLDT NDESDFISTL SYILPYFSAV NLDVKSLLLP
FIKLPTTGNS LAKIQTVGQN RQRVKRVLMG PRSIQKRHFK EVGRQSIRRE QGAQASVENA
AEEKRLTSPA PREVEQPHTQ QGPEKLAGNA VYTKPSFTQE HKAAVSVLKP FSKGTPSTSS
PAKALPQVRD RSKDLTHAIS ILESAKARVT NTKTSKPIVH ARKKYRFHKT RSHVTHRTTK
VKKSPKVRKK SYLSRLMLAN RLPFSAAKSL INSPSQGAFS SLGDLSPQEN PFLEVSALSE
HFIEKNNTKH TTARNAFEEN DFMENTNMPE GTISENTNYN HPPEADSAGT AFNLGPTVKQ
TETKWEYNNV GTDLSPEPKS FNYPLLSSPG DQFEIQLTQQ LQSLIPNNNV RRLIAHVIRT
LKMDCSGAHV QVTCAKLISR TGHLMKLLSG QQEVKASKIE WDTDQWKIEN YINESTEAQS
EQKEKSLELK KEVPGYGYTD KLILALIVTG ILTILIILFC LIVICCHRRS LQEDEEGFSR
GIFRFLPWRG CSSRRESQDG LSSFGQPLWF KDLYKPLSAT RINNHAWKLH KKSSNEDKIL
NRDPGDSEAP TEEEESEALP
