L37A2_HUMAN
ID L37A2_HUMAN Reviewed; 1700 AA.
AC A6NM11; B7ZMC3;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Leucine-rich repeat-containing protein 37A2;
DE Flags: Precursor;
GN Name=LRRC37A2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 779-1700, AND VARIANTS LEU-1141;
RP THR-1281; LYS-1385 AND PRO-1423.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the LRRC37A family. {ECO:0000305}.
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DR EMBL; AC138645; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC144427; AAI44428.1; -; mRNA.
DR CCDS; CCDS42353.1; -.
DR RefSeq; NP_001006608.2; NM_001006607.2.
DR AlphaFoldDB; A6NM11; -.
DR SMR; A6NM11; -.
DR BioGRID; 138737; 10.
DR IntAct; A6NM11; 6.
DR STRING; 9606.ENSP00000459551; -.
DR GlyGen; A6NM11; 2 sites.
DR iPTMnet; A6NM11; -.
DR PhosphoSitePlus; A6NM11; -.
DR BioMuta; LRRC37A2; -.
DR EPD; A6NM11; -.
DR MassIVE; A6NM11; -.
DR PaxDb; A6NM11; -.
DR PeptideAtlas; A6NM11; -.
DR PRIDE; A6NM11; -.
DR ProteomicsDB; 1505; -.
DR Antibodypedia; 70905; 11 antibodies from 5 providers.
DR DNASU; 474170; -.
DR Ensembl; ENST00000576629.5; ENSP00000459551.1; ENSG00000238083.8.
DR GeneID; 474170; -.
DR KEGG; hsa:474170; -.
DR MANE-Select; ENST00000576629.6; ENSP00000459551.1; NM_001006607.3; NP_001006608.2.
DR UCSC; uc002ikn.2; human.
DR CTD; 474170; -.
DR DisGeNET; 474170; -.
DR GeneCards; LRRC37A2; -.
DR HGNC; HGNC:32404; LRRC37A2.
DR HPA; ENSG00000238083; Group enriched (brain, testis).
DR MalaCards; LRRC37A2; -.
DR MIM; 616556; gene.
DR neXtProt; NX_A6NM11; -.
DR PharmGKB; PA162394530; -.
DR VEuPathDB; HostDB:ENSG00000238083; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00530000063282; -.
DR HOGENOM; CLU_003362_0_0_1; -.
DR InParanoid; A6NM11; -.
DR OMA; SANICEL; -.
DR OrthoDB; 181606at2759; -.
DR PhylomeDB; A6NM11; -.
DR TreeFam; TF341959; -.
DR PathwayCommons; A6NM11; -.
DR SignaLink; A6NM11; -.
DR BioGRID-ORCS; 474170; 15 hits in 643 CRISPR screens.
DR ChiTaRS; LRRC37A2; human.
DR GenomeRNAi; 474170; -.
DR Pharos; A6NM11; Tdark.
DR PRO; PR:A6NM11; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; A6NM11; protein.
DR Bgee; ENSG00000238083; Expressed in right uterine tube and 93 other tissues.
DR Genevisible; A6NM11; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR015753; LRRC37.
DR InterPro; IPR032754; LRRC37_N.
DR InterPro; IPR029423; LRRC37AB_C.
DR PANTHER; PTHR23045; PTHR23045; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF15779; LRRC37; 7.
DR Pfam; PF14914; LRRC37AB_C; 1.
DR SMART; SM00369; LRR_TYP; 4.
DR PROSITE; PS51450; LRR; 4.
PE 2: Evidence at transcript level;
KW Glycoprotein; Leucine-rich repeat; Membrane; Reference proteome; Repeat;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..35
FT /evidence="ECO:0000255"
FT CHAIN 36..1700
FT /note="Leucine-rich repeat-containing protein 37A2"
FT /id="PRO_0000337080"
FT TOPO_DOM 36..1582
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1583..1603
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1604..1700
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 137..160
FT /note="LRR 1"
FT REPEAT 230..253
FT /note="LRR 2"
FT REPEAT 267..290
FT /note="LRR 3"
FT REPEAT 864..887
FT /note="LRR 4"
FT REPEAT 888..911
FT /note="LRR 5"
FT REPEAT 912..935
FT /note="LRR 6"
FT REPEAT 937..959
FT /note="LRR 7"
FT REPEAT 963..987
FT /note="LRR 8"
FT REPEAT 1002..1027
FT /note="LRR 9"
FT REPEAT 1124..1146
FT /note="LRR 10"
FT REGION 54..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 130..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 169..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 559..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 619..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 729..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1182..1227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1309..1328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1675..1700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..156
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..279
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..386
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..521
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 729..748
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 296
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1079
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 1141
FT /note="F -> L (in dbSNP:rs1863115)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_070799"
FT VARIANT 1281
FT /note="I -> T (in dbSNP:rs62073349)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_070800"
FT VARIANT 1385
FT /note="N -> K (in dbSNP:rs1969205)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_070801"
FT VARIANT 1423
FT /note="H -> P (in dbSNP:rs201103889)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_070802"
FT CONFLICT 1508
FT /note="A -> T (in Ref. 2; AAI44428)"
FT /evidence="ECO:0000305"
FT CONFLICT 1628
FT /note="W -> R (in Ref. 2; AAI44428)"
FT /evidence="ECO:0000305"
FT CONFLICT 1686..1687
FT /note="Missing (in Ref. 2; AAI44428)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1700 AA; 188393 MW; B80368373F772CDF CRC64;
MSSAQCPALV CVMSRLRFWG PWPLLMWQLL WLLVKEAQPL EWVKDPLQLT SNPLGPPDSW
SSHSSHFPRE SPHAPTLPAD PWDFDHLGPS ASSEMPAPPQ ESTENLVPFL DTWDSAGEQP
LEPEQFLASQ QDLKDKLSPQ ERLPVSPKKL KKDPAQRWSL AEIIGITRQL STPQSQKQTL
QNEYSSTDTP YPGSLPPELR VKSDEPPGPS EQVGPSQFHL EPETQNPETL EDIQSSSLQQ
EAPAQLPQLL EEEPSSMQQE APALPPESSM ESLTLPNHEV SVQPPGEDQA YYHLPNITVK
PADVEVTITS EPTNETESSQ AQQETPIQFP EEVEPSATQQ EAPIEPPVPP MEHELSISEQ
QQPVQPSESP REVESSPTQQ ETPGQPPEHH EVTVSPPGHH QTHHLASPSV SVKPPDVQLT
IAAEPSAEVG TSLVHQEATT RLSGSGNDVE PPAIQHGGPP LLPESSEEAG PLAVQQETSF
QSPEPINNEN PSPTQQEAAA EHPQTAEEGE SSLTHQEAPA QTPEFPNVVV AQPPEHSHLT
QATVQPLDLG FTITPESKTE VELSPTMKET PTQPPKKVVP QLRVYQGVTN PTPGQDQAQH
PVSPSVTVQL LDLGLTITPE PTTEVGHSTP PKRTIVSPKH PEVTLPHPDQ VQTQHSHLTR
ATVQPLDLGF TITPKSMTEV EPSTALMTTA PPPGHPEVTL PPSDKGQAQH SHLTQATVQP
LDLELTITTK PTTEVKPSPT TEETSTQPPD LGLAIIPEPT TETRHSTALE KTTAPRPDRV
QTLHRSLTEV TGPPTELEPA QDSLVQSESY TQNKALTAPE EHKASTSTNI CELCTCGDEM
LSCIDLNPEQ RLRQVPVPEP NTHNGTFTIL NFQGNYISYI DGNVWKAYSW TEKLILRENN
LTELHKDSFE GLLSLQYLDL SCNKIQSIER HTFEPLPFLK FINLSCNVIT ELSFGTFQAW
HGMQFLHKLI LNHNPLTTVE DPYLFKLPAL KYLDMGTTLV PLTTLKNILM MTVELEKLIL
PSHMACCLCQ FKNSIEAVCK TVKLHCNSAC LTNTTHCPEE ASVGNPEGAF MKVLQARKNY
TSTELIVEPE EPSDSSGINL SGFGSEQLDT NDESDFISTL SYILPYFSAV NLDVKSLLLP
FIKLPTTGNS LAKIQTVGQN RQRVKRVLMG PRSIQKRHFK EVGRQSIRRE QGAQASVENA
AEEKRLGSPA PREVEQPHTQ QGPEKLAGNA VYTKPSFTQE HKAAVSVLKP FSKGAPSTSS
PAKALPQVRD RWKDLTHAIS ILESAKARVT NTKTSKPIVH ARKKYRFHKT RSHVTHRTPK
VKKSPKVRKK SYLSRLMLAN RLPFSAAKSL INSPSQGAFS SLGDLSPQEN PFLEVSAPSE
HFIENNNTKH TTARNAFEEN DFMENTNMPE GTISENTNYN HPHEADSAGT AFNLGPTVKQ
TETKWEYNNV GTDLSPEPKS FNYPLLSSPG DQFEIQLTQQ LQSLIPNNNV RRLIAHVIRT
LKMDCSGAHV QVTCAKLISR TGHLMKLLSG QQEVKASKIE WDTDQWKIEN YINESTEAQS
EQKEKSLELK KEVPGYGYTD KLILALIVTG ILTILIILFC LIVICCHRRS LQEDEEGFSR
GIFRFLPWRG CSSRRESQDG LSSFGQPLWF KDMYKPLSAT RINNHAWKLH KKSSNEDKIL
NRDPGDSEAP TEEEESEALP
