L37A3_HUMAN
ID L37A3_HUMAN Reviewed; 1634 AA.
AC O60309; Q49A01; Q49A80; Q8NB33;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 2.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Leucine-rich repeat-containing protein 37A3;
DE Flags: Precursor;
GN Name=LRRC37A3; Synonyms=KIAA0563;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=9628581; DOI=10.1093/dnares/5.1.31;
RA Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N.,
RA Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. IX. The
RT complete sequences of 100 new cDNA clones from brain which can code for
RT large proteins in vitro.";
RL DNA Res. 5:31-39(1998).
RN [2]
RP SEQUENCE REVISION.
RA Ohara O., Nagase T., Kikuno R., Ishikawa K.;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1019-1634.
RC TISSUE=Fetal brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the LRRC37A family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA25489.3; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC03710.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB011135; BAA25489.3; ALT_INIT; mRNA.
DR EMBL; BC043145; AAH43145.1; -; mRNA.
DR EMBL; AK091625; BAC03710.1; ALT_INIT; mRNA.
DR CCDS; CCDS32708.1; -.
DR RefSeq; NP_955372.2; NM_199340.3.
DR AlphaFoldDB; O60309; -.
DR SMR; O60309; -.
DR BioGRID; 131922; 2.
DR STRING; 9606.ENSP00000464535; -.
DR GlyGen; O60309; 2 sites.
DR iPTMnet; O60309; -.
DR PhosphoSitePlus; O60309; -.
DR BioMuta; LRRC37A3; -.
DR EPD; O60309; -.
DR MassIVE; O60309; -.
DR PaxDb; O60309; -.
DR PeptideAtlas; O60309; -.
DR PRIDE; O60309; -.
DR ProteomicsDB; 49338; -.
DR Antibodypedia; 45816; 26 antibodies from 12 providers.
DR DNASU; 374819; -.
DR Ensembl; ENST00000319651.9; ENSP00000325713.5; ENSG00000176809.11.
DR Ensembl; ENST00000584306.6; ENSP00000464535.1; ENSG00000176809.11.
DR GeneID; 374819; -.
DR KEGG; hsa:374819; -.
DR MANE-Select; ENST00000584306.6; ENSP00000464535.1; NM_199340.5; NP_955372.2.
DR UCSC; uc002jey.3; human.
DR CTD; 374819; -.
DR DisGeNET; 374819; -.
DR GeneCards; LRRC37A3; -.
DR HGNC; HGNC:32427; LRRC37A3.
DR HPA; ENSG00000176809; Tissue enhanced (testis).
DR MIM; 616557; gene.
DR neXtProt; NX_O60309; -.
DR OpenTargets; ENSG00000176809; -.
DR PharmGKB; PA162394563; -.
DR VEuPathDB; HostDB:ENSG00000176809; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00530000063282; -.
DR HOGENOM; CLU_003362_0_0_1; -.
DR InParanoid; O60309; -.
DR OMA; PIRASHM; -.
DR OrthoDB; 181606at2759; -.
DR PhylomeDB; O60309; -.
DR TreeFam; TF341959; -.
DR PathwayCommons; O60309; -.
DR BioGRID-ORCS; 374819; 383 hits in 998 CRISPR screens.
DR ChiTaRS; LRRC37A3; human.
DR GenomeRNAi; 374819; -.
DR Pharos; O60309; Tdark.
DR PRO; PR:O60309; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; O60309; protein.
DR Bgee; ENSG00000176809; Expressed in right uterine tube and 149 other tissues.
DR ExpressionAtlas; O60309; baseline and differential.
DR Genevisible; O60309; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR015753; LRRC37.
DR InterPro; IPR032754; LRRC37_N.
DR InterPro; IPR029423; LRRC37AB_C.
DR PANTHER; PTHR23045; PTHR23045; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF15779; LRRC37; 6.
DR Pfam; PF14914; LRRC37AB_C; 1.
DR SMART; SM00369; LRR_TYP; 4.
DR PROSITE; PS51450; LRR; 4.
PE 2: Evidence at transcript level;
KW Glycoprotein; Leucine-rich repeat; Membrane; Reference proteome; Repeat;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..35
FT /evidence="ECO:0000255"
FT CHAIN 36..1634
FT /note="Leucine-rich repeat-containing protein 37A3"
FT /id="PRO_0000076244"
FT TOPO_DOM 36..1581
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1582..1602
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1603..1634
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 137..160
FT /note="LRR 1"
FT REPEAT 230..253
FT /note="LRR 2"
FT REPEAT 267..290
FT /note="LRR 3"
FT REPEAT 864..887
FT /note="LRR 4"
FT REPEAT 888..911
FT /note="LRR 5"
FT REPEAT 912..935
FT /note="LRR 6"
FT REPEAT 937..959
FT /note="LRR 7"
FT REPEAT 963..987
FT /note="LRR 8"
FT REPEAT 1002..1027
FT /note="LRR 9"
FT REPEAT 1124..1146
FT /note="LRR 10"
FT REPEAT 1151..1176
FT /note="LRR 11"
FT REPEAT 1359..1384
FT /note="LRR 12"
FT REGION 53..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 172..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 619..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 758..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1181..1227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1306..1329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1614..1634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..279
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..386
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..521
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 296
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1079
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 1215
FT /note="K -> E (in dbSNP:rs9893710)"
FT /id="VAR_051088"
FT VARIANT 1590
FT /note="G -> A (in dbSNP:rs28532307)"
FT /id="VAR_061672"
FT CONFLICT 51
FT /note="S -> P (in Ref. 3; AAH43145)"
FT /evidence="ECO:0000305"
FT CONFLICT 1086
FT /note="I -> T (in Ref. 3; AAH43145)"
FT /evidence="ECO:0000305"
FT CONFLICT 1417
FT /note="T -> A (in Ref. 3; AAH43145)"
FT /evidence="ECO:0000305"
FT CONFLICT 1419
FT /note="Y -> H (in Ref. 4; BAC03710)"
FT /evidence="ECO:0000305"
FT CONFLICT 1619
FT /note="S -> P (in Ref. 4; BAC03710)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1634 AA; 180621 MW; 84C8F93290B29EB1 CRC64;
MTSAQCPALA CVMSPLRFWG PWPLLMWQLL WLLVKEAQPL EWVKDPLQLT SNPLGPPEPW
SSHSSHFPRE SPHAPTLPAD PWDFDHLGPS ASSEMPAPPQ ESTENLVPFL DTWDSAGELP
LEPEQFLASQ QDLKDKLSPQ ERLPVSPKKL KKDPAQRWSL AEIIGIIHQL STPQSQKQTL
QNEYSSTDTP YPGSLPPELR VKSDEPPGPS EQVGPSQFHL EPETQNPETL EDIQSSSLQQ
EAPAQLPQLL EEEPSSMQQE APALPPESSM ESLTLPNHEV SVQPPGEDQA YYHLPNITVK
PADVEVTITS EPTNETESSQ AQQETPIQFP EEVEPSATQQ EAPIEPPVPP MEHELSISEQ
QQPVQPSESS REVESSPTQQ ETPGQPPEHH EVTVSPPGHH QTHHLASPSV SVKPPDVQLT
IAAEPSAEVG TSLVHQEATT RLSGSGNDVE PPAIQHGGPP LLPESSEEAG PLAVQQETSF
QSPEPINNEN PSPTQQEAAA EHPQTAEEGE SSLTHQEAPA QTPEFPNVVV AQPPEHSHLT
QATVQPLDLG FTITPESMTE VELSPTMKET PTQPPKKVVP QLRVYQGVTN PTPGQDQAQH
PVSPSVTVQL LDLGLTITPE PTTEVGHSTP PKRTIVSPKH PEVTLPHPDQ VQTQHSHLTR
ATVQPLDLGF TITPKSMTEV EPSTALMTTA PPPGHPEVTL PPSDKGQAQH SHLTQATVQP
LDLELTITTK PTTEVKPSPT TEETSTQLPD LGLAIIPEPT TETGHSTALE KTTAPRPDRV
QTLHRSLTEV TGPPTELEPA QDSLVQSESY TQNKALTAPE EHKASTSTNI CELCTCGDEM
LSCIDLNPEQ RLRQVPVPEP NTHNGTFTIL NFQGNYISYI DGNVWKAYSW TEKLILRENN
LTELHKDSFE GLLSLQYLDL SCNKIQSIER HTFEPLPFLK FINLSCNVIT ELSFGTFQAW
HGMQFLHKLI LNHNPLTTVE DPYLFKLPAL KYLDMGTTLV PLTTLKNILM MTVELEKLIV
PSHMACCLCQ FKNSIEAVCK TVKLHCNSAC LTNTTHCPEE ASVGNPEGAF MKVLQARKNY
TSTELIIEPE EPSDSSGINL SGFGSEQLDT NDESDVTSTL SYILPYFSAV NLDVKSLLLP
FIKLPTTGNS LAKIQTVGKN RQRLNRVLMG PRSIQKRHFK EVGRQSIRRE QGAQASVENT
AEEKRLGSPA PRELKQPHTQ QGPEKLAGNA VYTKPSFTQE HKAAVSVLKP FSKGAPSTSS
PAKALPQVRD RWKDLTHAIS ILESAKARVT NMKTSKPIVH SRKKYRFHKT RSRMTHRTPK
VKKSPKVRKK SYLSRLMLSN RLPFSAAKSL INSPSQGAFS SLRDLSPQEN PFLEVSAPSE
HFIENNNTKD TTARNAFEEN VFMENTNMPE GTISENTNYN HPPEADSAGT AFNLGPTVKQ
TETKWEYNNV GTDLSPEPKS FNYPLLSSPG DQFEIQLTQQ LQSVIPNNNV RRLIAHVIRT
LKMDCSGAHV QVTCAKLVSR TGHLMKLLSG QQEVKASKIE WDTDQWKTEN YINESTEAQS
EQKEKSLEFT KELPGYGYTK KLILALIVTG ILTILIILLC LIEICCHRRS LQEDEEGFSR
DSEAPTEEES EALP
