ID   L3BPA_DANRE             Reviewed;         567 AA.
AC   Q24JV9;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Galectin-3-binding protein A;
DE   AltName: Full=Lectin galactoside-binding soluble 3-binding protein A;
DE   Flags: Precursor;
GN   Name=lgals3bpa; Synonyms=lgals3bp; ORFNames=zgc:136780;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Promotes integrin-mediated cell adhesion. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Secreted, extracellular
CC       space, extracellular matrix {ECO:0000250}.
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DR   EMBL; BC114268; AAI14269.1; -; mRNA.
DR   RefSeq; NP_001035130.1; NM_001040041.1.
DR   AlphaFoldDB; Q24JV9; -.
DR   SMR; Q24JV9; -.
DR   STRING; 7955.ENSDARP00000055087; -.
DR   PaxDb; Q24JV9; -.
DR   GeneID; 677742; -.
DR   KEGG; dre:677742; -.
DR   CTD; 677742; -.
DR   ZFIN; ZDB-GENE-060331-57; lgals3bp.3.
DR   eggNOG; ENOG502QU48; Eukaryota.
DR   InParanoid; Q24JV9; -.
DR   OrthoDB; 1174057at2759; -.
DR   PhylomeDB; Q24JV9; -.
DR   Reactome; R-DRE-114608; Platelet degranulation.
DR   PRO; PR:Q24JV9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.250.10; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR001190; SRCR.
DR   InterPro; IPR017448; SRCR-like_dom.
DR   InterPro; IPR036772; SRCR-like_dom_sf.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF00530; SRCR; 1.
DR   PRINTS; PR00258; SPERACTRCPTR.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00202; SR; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   SUPFAM; SSF56487; SSF56487; 1.
DR   PROSITE; PS00420; SRCR_1; 1.
DR   PROSITE; PS50287; SRCR_2; 1.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Disulfide bond; Extracellular matrix; Glycoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..567
FT                   /note="Galectin-3-binding protein A"
FT                   /id="PRO_0000357038"
FT   DOMAIN          34..133
FT                   /note="SRCR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT   DOMAIN          272..374
FT                   /note="BACK"
FT   CARBOHYD        137
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        197
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        200
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        204
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        412
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        432
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        543
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        58..122
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT   DISULFID        71..132
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT   DISULFID        102..112
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
SQ   SEQUENCE   567 AA;  64131 MW;  F74B8FEF056CD35B CRC64;
     MIMYIIWALL FIPVSAQQWT LFDEQAKPKR EGRVRLVGGL PSSGRVEVYH DGQWGTVCDD
     GWDLAEAQVV CRQLGFPGAV SVASGGQYGE GSGPIWLDDM NCKGSESILS ECCFKGWGVN
     DCTHQEDAGV VCDTGTNATN IRQISVDNSL GLSDDLGLLF DSEDGCDFII AVQDLGEEAE
     LTLCVHRVIL MMYPELNITN DTRNLTVDVS QTCQSHVSAL IRYLYTRQID VSATSAQCLY
     QLAFIFGVQR LMEDVGRVFT ALIPEDNTFQ TPVSMYEYGL RTGDLVLQEN VLQYLSWNCE
     FLISSPVWST VSFEMMDALL QRSDLIVKDE AVLLEALERW IQDKGDQISS DKQASLLSHI
     RFLLIPVDKL YDIQFSSSAL YQNNEKLYLT GLLRGFEFNA LPFSKIRNQI DNASSEYLPR
     IYTGDEWSVF INDTTVSSPY YNYNYYGQSN RIQTFFTSAH PSALYKDQKV QWQAQVFLTL
     QECSNYGVSC NTLPVARFYG YSNQYSYSNI ISYNNRLILT CKNQNNVFHV QEFKNDVAVI
     PTNSSMGLPN PCPDDYSFRF VVRPQYI