ID   L3BPB_DANRE             Reviewed;         572 AA.
AC   Q6NY73;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Galectin-3-binding protein B;
DE   AltName: Full=Lectin galactoside-binding soluble 3-binding protein B;
DE   Flags: Precursor;
GN   Name=lgals3bpb; ORFNames=zgc:77059;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Promotes integrin-mediated cell adhesion. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Secreted, extracellular
CC       space, extracellular matrix {ECO:0000250}.
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DR   EMBL; BC066712; AAH66712.1; -; mRNA.
DR   RefSeq; NP_998038.1; NM_212873.1.
DR   AlphaFoldDB; Q6NY73; -.
DR   SMR; Q6NY73; -.
DR   STRING; 7955.ENSDARP00000092605; -.
DR   PaxDb; Q6NY73; -.
DR   PRIDE; Q6NY73; -.
DR   GeneID; 405809; -.
DR   KEGG; dre:405809; -.
DR   CTD; 405809; -.
DR   ZFIN; ZDB-GENE-040426-2262; lgals3bp.1.
DR   eggNOG; ENOG502QU48; Eukaryota.
DR   InParanoid; Q6NY73; -.
DR   OrthoDB; 1174057at2759; -.
DR   PhylomeDB; Q6NY73; -.
DR   PRO; PR:Q6NY73; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.250.10; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR001190; SRCR.
DR   InterPro; IPR017448; SRCR-like_dom.
DR   InterPro; IPR036772; SRCR-like_dom_sf.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF00530; SRCR; 1.
DR   PRINTS; PR00258; SPERACTRCPTR.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00202; SR; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   SUPFAM; SSF56487; SSF56487; 1.
DR   PROSITE; PS50097; BTB; 1.
DR   PROSITE; PS00420; SRCR_1; 1.
DR   PROSITE; PS50287; SRCR_2; 1.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Disulfide bond; Extracellular matrix; Glycoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..14
FT                   /evidence="ECO:0000255"
FT   CHAIN           15..572
FT                   /note="Galectin-3-binding protein B"
FT                   /id="PRO_0000357039"
FT   DOMAIN          32..131
FT                   /note="SRCR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT   DOMAIN          164..231
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          270..372
FT                   /note="BACK"
FT   CARBOHYD        135
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        195
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        202
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        430
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        548
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        56..120
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT   DISULFID        69..130
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT   DISULFID        100..110
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
SQ   SEQUENCE   572 AA;  64901 MW;  206BFBC94F319322 CRC64;
     MLLLWPLLFL QVSALRRTLF DRPKQLMQEG RVRLVGVIPS SGRVEVYHDG QWGTVCDDGW
     DLAEAQVVCR QLGFPGAVSV ATGGQYGEGS GRVWLDDMNC KGSESLLSEC SFKGWGVSDC
     THKEDAGVIC APGKNTTSIR QMSVDNSLGL SDDLGLLFDS EDGCDFTIAV RDLSEEAELT
     FCVHRVILMI YPELNLTHDT RNITVDISQT CHTHVPRFLR YLYTRQIDVS TTSAQCLHQL
     AFIFGVQKLM EDVGRVFTAL IPEDNTFQTQ VSMYEYGVRT GDLVLQENVL QYLSWNCEFL
     ISSPVWSTVS FDMMDALLQR SDLIVKDEAV LLEALERWIQ DKGDQISSDK QVSLLNHIRF
     LLIPVDKLYD IQFSSSALRQ SNEKLYLTGL LRGFQFNALP FSKIRDQVVK LSGNYIPRIY
     IGDEWSLGLN VSTVNNPHYN PYQYGYDQRY GQSNRIEKYL STPAHPSAVY RGQMIQWQAQ
     VFRSVQDCRN SGISCNSVPL VRFLATSSQY SYSSTIRYNN RLVLTCKNQN NVFHVQDFKN
     NMAVIPTNSS MGLPNPCPDD YSFRFVVRPQ YI