ID   L3_VACCW                Reviewed;         350 AA.
AC   P07614; Q76ZT6;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   29-SEP-2021, entry version 58.
DE   RecName: Full=Protein L3;
DE   AltName: Full=Protein F4;
GN   Name=VACWR090; ORFNames=F4;
OS   Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
OS   WR)).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10254;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2987815; DOI=10.1093/nar/13.3.985;
RA   Plucienniczak A., Schroeder E., Zettlmeissl G., Streeck R.E.;
RT   "Nucleotide sequence of a cluster of early and late genes in a conserved
RT   segment of the vaccinia virus genome.";
RL   Nucleic Acids Res. 13:985-998(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J.,
RA   Wohlhueter R.;
RT   "Sequencing of the coding region of Vaccinia-WR to an average 9-fold
RT   redundancy and an error rate of 0.16/10kb.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION, SUBCELLULAR LOCATION, AND INDUCTION.
RX   PubMed=16282472; DOI=10.1128/jvi.79.23.14719-14729.2005;
RA   Resch W., Moss B.;
RT   "The conserved poxvirus L3 virion protein is required for transcription of
RT   vaccinia virus early genes.";
RL   J. Virol. 79:14719-14729(2005).
CC   -!- FUNCTION: Might be required for transcription of early genes.
CC       {ECO:0000269|PubMed:16282472}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:16282472}. Host
CC       cytoplasm {ECO:0000269|PubMed:16282472}. Note=Localizes in cytoplasmic
CC       virus factories and present in the virion core.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC       {ECO:0000269|PubMed:16282472}.
CC   -!- SIMILARITY: Belongs to the poxviridae L3 family. {ECO:0000305}.
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DR   EMBL; X01978; CAA26012.1; -; Genomic_DNA.
DR   EMBL; AY243312; AAO89369.1; -; Genomic_DNA.
DR   PIR; A26216; QQVZF4.
DR   RefSeq; YP_232972.1; NC_006998.1.
DR   DNASU; 3707546; -.
DR   GeneID; 3707546; -.
DR   KEGG; vg:3707546; -.
DR   Proteomes; UP000000344; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR005007; Poxvirus_L3/FP4.
DR   Pfam; PF03339; Pox_L3_FP4; 1.
PE   2: Evidence at transcript level;
KW   Host cytoplasm; Late protein; Reference proteome; Virion.
FT   CHAIN           1..350
FT                   /note="Protein L3"
FT                   /id="PRO_0000099622"
FT   REGION          1..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..36
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   350 AA;  40621 MW;  74EF2C3AAADF6F91 CRC64;
     MNTRTDVTND NIDKNPTKRG DKNIPGRNER FNDQNRFNND IPKPKPRLQP NQPPKQDNKC
     REENGDFINI RLCAYEKEYC NDGYLSPAYY MLKQVDDEEM SCWSELSSLV RSRKAVGFPL
     LKAAKRISHG SMLYFEQFKN SKVVRLTPQV KCLNDTVIFQ TVVILYSMYK RGIYSNEFCF
     DLVSIPRTNI VFSVNQLMFN ICTDILVVLS ICGNRLYRTN LPQSCYLNFI HGHETIARRG
     YEHSNYFFEW LIKNHISLLT KQTMDILKVK KKYAIGAPVN RLLEPGTLVY VPKEDYYFIG
     ISLTDVSISD NVRVLFSTDG IVLEIEDFNI KHLFMAGEMF VRSQSSTIIV