ID   L3_VAR67                Reviewed;         349 AA.
AC   P0DSZ1; P33042;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   29-SEP-2021, entry version 7.
DE   RecName: Full=Protein L3;
GN   ORFNames=L3L, M3L;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8383392; DOI=10.1016/0168-1702(93)90110-9;
RA   Shchelkunov S.N., Blinov V.M., Totmenin A.V., Marennikova S.S.,
RA   Kolykhalov A.A., Frolov I.V., Chizhikov V.E., Gytorov V.V., Gashikov P.V.,
RA   Belanov E.F., Belavin P.A., Resenchuk S.M., Andzhaparidze O.G.,
RA   Sandakhchiev L.S.;
RT   "Nucleotide sequence analysis of variola virus HindIII M, L, I genome
RT   fragments.";
RL   Virus Res. 27:25-35(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
CC   -!- FUNCTION: Might be required for transcription of early genes.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host cytoplasm
CC       {ECO:0000250}. Note=Localizes in cytoplasmic virus factories and
CC       present in the virion core. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae L3 family. {ECO:0000305}.
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DR   EMBL; X67119; CAA47574.1; -; Genomic_DNA.
DR   EMBL; S55844; AAB24671.1; -; Genomic_DNA.
DR   EMBL; X69198; CAA49016.1; -; Genomic_DNA.
DR   PIR; S33089; S33089.
DR   RefSeq; NP_042119.1; NC_001611.1.
DR   GeneID; 1486472; -.
DR   KEGG; vg:1486472; -.
DR   Proteomes; UP000002060; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR005007; Poxvirus_L3/FP4.
DR   Pfam; PF03339; Pox_L3_FP4; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Late protein; Reference proteome; Virion.
FT   CHAIN           1..349
FT                   /note="Protein L3"
FT                   /id="PRO_0000099623"
FT   REGION          1..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..40
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   349 AA;  40460 MW;  8CEF789F1C1C60A3 CRC64;
     MNTRTDVTND NIDKNPTKRG NKNIPGRNER FNDRNRFNND GNNRPRLQPS PPPRQDNKCR
     EENGDFINIR LCAYEKEYCN DGYLSPAYYM LKQVDDEEMS CWSELSSLVR SKKAVGFPLL
     KAAKRISHGS MLYFEQFKNS KVVRLTPQVK CLNDTVIFQT VVILYSMYKR DIYSNEFCFD
     LVSIPRTNIV FSVNQLMFNI CTDILVVLSI CGNRLYRTNL PQSCYLNFIH GHETIACRGY
     EHSNYFFEWL IKNHLSLLTK QTMDILKVKK KYATGAPVNR LLEPGTLVYV PKEDYYFIGI
     SLTDVSISDN VRVLFSTDGI VLEIEDFNIK HLFMAGEMFV RSQSSTIIV