ID   LA1_HETSP               Reviewed;          97 AA.
AC   K7WMX6;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2013, sequence version 1.
DT   25-MAY-2022, entry version 16.
DE   RecName: Full=Venom peptide HsVx1;
DE   AltName: Full=HsTx1 protein;
DE   Flags: Precursor;
OS   Heterometrus spinifer (Asia giant forest scorpion) (Malaysian black
OS   scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Iurida; Scorpionoidea; Scorpionidae; Heterometrinae;
OC   Heterometrus.
OX   NCBI_TaxID=118530;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=23099316; DOI=10.1016/j.peptides.2012.10.004;
RA   Zeng X.C., Nie Y., Luo X., Wu S., Shi W., Zhang L., Liu Y., Cao H.,
RA   Yang Y., Zhou J.;
RT   "Molecular and bioinformatical characterization of a novel superfamily of
RT   cysteine-rich peptides from arthropods.";
RL   Peptides 41:45-58(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- PTM: Contains 4 disulfide bonds. {ECO:0000250}.
CC   -!- MISCELLANEOUS: This recombinant protein is not able to act on sodium
CC       channels (Nav). {ECO:0000305|PubMed:23099316}.
CC   -!- SIMILARITY: Belongs to the scorpion La1-like peptide family.
CC       {ECO:0000305}.
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DR   EMBL; JQ821370; AFR60582.1; -; Genomic_DNA.
DR   EMBL; KC140563; AFX60852.1; -; mRNA.
DR   AlphaFoldDB; K7WMX6; -.
DR   SMR; K7WMX6; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR029277; SVWC_dom.
DR   Pfam; PF15430; SVWC; 1.
DR   SMART; SM01318; SVWC; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Secreted; Signal; Toxin.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..97
FT                   /note="Venom peptide HsVx1"
FT                   /id="PRO_0000428818"
SQ   SEQUENCE   97 AA;  10333 MW;  F6F73474EA7817F6 CRC64;
     MSHLRIAVTF LCTLFALTAG AGESCQVGGS AIPVGKTKQE LCNLYECATD SNRVVLKKLT
     CAEQAVKTGC RSVPGDANAP FPDCCPTTLC RGRQWDH