ID   LA89_LACAI              Reviewed;          46 AA.
AC   Q48501; Q9R5H2;
DT   11-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Bacteriocin acidocin 8912;
DE   Flags: Precursor;
GN   Name=acdT;
OS   Lactobacillus acidophilus.
OG   Plasmid pLA103.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=1579;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=TK8912;
RX   PubMed=8554765; DOI=10.1111/j.1472-765x.1995.tb01087.x;
RA   Kanatani K., Tahara T., Oshimura M., Sano K., Umezawa C.;
RT   "Cloning and nucleotide sequence of the gene for acidocin 8912, a
RT   bacteriocin from Lactobacillus acidophilus TK8912.";
RL   Lett. Appl. Microbiol. 21:384-386(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=TK8912;
RA   Nakachi I.;
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   PROTEIN SEQUENCE OF 21-44.
RC   STRAIN=TK8912;
RX   PubMed=1368836; DOI=10.1271/bbb.56.1212;
RA   Tahara T., Kanatani K., Yoshida K., Miura H., Sakamoto M., Oshimura M.;
RT   "Purification and some properties of acidocin 8912, a novel bacteriocin
RT   produced by Lactobacillus acidophilus TK8912.";
RL   Biosci. Biotechnol. Biochem. 56:1212-1215(1992).
CC   -!- FUNCTION: Has a bactericidal effect on sensitive cells but not a
CC       bacteriolytic effect.
CC   -!- SUBCELLULAR LOCATION: Secreted.
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DR   EMBL; D43626; BAA07737.1; -; Genomic_DNA.
DR   EMBL; AB081463; BAB86322.1; -; Genomic_DNA.
DR   RefSeq; NP_604414.1; NC_003458.1.
DR   RefSeq; WP_011017212.1; NC_003458.1.
DR   AlphaFoldDB; Q48501; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR010133; Bacteriocin_signal_seq.
DR   TIGRFAMs; TIGR01847; bacteriocin_sig; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Bacteriocin; Direct protein sequencing; Plasmid;
KW   Secreted.
FT   PROPEP          1..20
FT                   /evidence="ECO:0000269|PubMed:1368836"
FT                   /id="PRO_0000002762"
FT   PEPTIDE         21..46
FT                   /note="Bacteriocin acidocin 8912"
FT                   /id="PRO_0000002763"
FT   CONFLICT        33
FT                   /note="W -> R (in Ref. 3; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   46 AA;  5331 MW;  EAF910D04D2AC3E8 CRC64;
     MISSHQKTLT DKELALISGG KTHYPTNAWK SLWKGFWESL RYTDGF