LAAT1_CHICK
ID LAAT1_CHICK Reviewed; 303 AA.
AC Q5ZJX0; E1BY15;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Lysosomal amino acid transporter 1 homolog {ECO:0000305};
DE AltName: Full=PQ-loop repeat-containing protein 2;
DE AltName: Full=Solute carrier family 66 member 1 {ECO:0000305};
GN Name=SLC66A1; Synonyms=PQLC2; ORFNames=RCJMB04_14o18;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Red jungle fowl;
RX PubMed=15592404; DOI=10.1038/nature03154;
RA Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P.,
RA Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B.,
RA Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C.,
RA Fulton R.S., Graves T.A., Kremitzki C., Layman D., Magrini V.,
RA McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O.,
RA Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W.,
RA Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D.,
RA Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K.,
RA Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L.,
RA Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B.,
RA Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M.,
RA Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M.,
RA Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S.,
RA Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M.,
RA Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M.,
RA Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A.,
RA Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S.,
RA Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J.,
RA Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J.,
RA Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E.,
RA Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M.,
RA Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A.,
RA Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E.,
RA Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S.,
RA Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E.,
RA Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R.,
RA Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R.,
RA Wilson R.K.;
RT "Sequence and comparative analysis of the chicken genome provide unique
RT perspectives on vertebrate evolution.";
RL Nature 432:695-716(2004).
CC -!- FUNCTION: Amino acid transporter that specifically mediates the pH-
CC dependent export of the cationic amino acids arginine, histidine and
CC lysine from lysosomes. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- DOMAIN: The di-leucine motif mediates lysosomal localization.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the laat-1 family. {ECO:0000305}.
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DR EMBL; AJ720314; CAG31973.1; -; mRNA.
DR EMBL; AADN02040695; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AADN02040696; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AADN02040697; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001006304.1; NM_001006304.1.
DR AlphaFoldDB; Q5ZJX0; -.
DR STRING; 9031.ENSGALP00000006392; -.
DR PaxDb; Q5ZJX0; -.
DR Ensembl; ENSGALT00000068441; ENSGALP00000055267; ENSGALG00000033204.
DR GeneID; 419472; -.
DR KEGG; gga:419472; -.
DR CTD; 419472; -.
DR VEuPathDB; HostDB:geneid_419472; -.
DR eggNOG; KOG2913; Eukaryota.
DR GeneTree; ENSGT00390000003344; -.
DR HOGENOM; CLU_019699_3_0_1; -.
DR InParanoid; Q5ZJX0; -.
DR OMA; LAQCFYY; -.
DR OrthoDB; 977963at2759; -.
DR PhylomeDB; Q5ZJX0; -.
DR Reactome; R-GGA-5223345; Miscellaneous transport and binding events.
DR PRO; PR:Q5ZJX0; -.
DR Proteomes; UP000000539; Chromosome 21.
DR Bgee; ENSGALG00000033204; Expressed in granulocyte and 13 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0031301; C:integral component of organelle membrane; ISS:UniProtKB.
DR GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR GO; GO:0015174; F:basic amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0061459; F:L-arginine transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0015189; F:L-lysine transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0080144; P:amino acid homeostasis; ISS:UniProtKB.
DR GO; GO:1903826; P:L-arginine transmembrane transport; ISS:UniProtKB.
DR GO; GO:0015819; P:lysine transport; ISS:UniProtKB.
DR InterPro; IPR006603; PQ-loop_rpt.
DR Pfam; PF04193; PQ-loop; 2.
DR SMART; SM00679; CTNS; 2.
PE 2: Evidence at transcript level;
KW Amino-acid transport; Glycoprotein; Lysosome; Membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..303
FT /note="Lysosomal amino acid transporter 1 homolog"
FT /id="PRO_0000282436"
FT TOPO_DOM 1..38
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..73
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 95..96
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 118..131
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 153..182
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 204..220
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 242..260
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..281
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 282..303
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 36..102
FT /note="PQ-loop 1"
FT DOMAIN 186..251
FT /note="PQ-loop 2"
FT MOTIF 296..297
FT /note="Di-leucine motif"
FT CARBOHYD 13
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 303 AA; 32167 MW; C42ED476B0D13183 CRC64;
MAEGLRAPPP PGNGSECPDG ARWVLRLLGE CARDGRDVGS ALLGLLSIGC FAAAALPQFY
QACKTGIMDR ALSIYFLLGW LGGDLLNLIG SFLANQLPLQ VYTAVYYVLA DLVMLSLYGY
YKAKNWGTGA TASINAACLF CLLGTATTLT VLSHDTGPAP NPAAFGGRSL LSLGLEGPGP
EPISKTEIIG FAIGSISSVL YLCSRLPQIY TNYRRKSTAG VSFLLFALVM LGNLLYGTSV
LLKNPEPGQS EGDYILHHLP WLIGSLGVLS LDVIISFQFL AYRTGQPSAG EEREALLAEH
GDS
