ID   LABA_JATMU              Reviewed;          10 AA.
AC   P13270;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   11-DEC-2019, entry version 40.
DE   RecName: Full=Labaditin;
OS   Jatropha multifida (Coralbush).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Jatropheae;
OC   Jatropha.
OX   NCBI_TaxID=3996;
RN   [1]
RP   PROTEIN SEQUENCE, AND CROSS-LINK.
RC   TISSUE=Latex;
RA   Kosasi S., van der Sluis W.G., Boelens R., T'Hart L.A., Labadie R.P.;
RT   "Labaditin, a novel cyclic decapeptide from the latex of Jatropha multifida
RT   L. (Euphorbiaceae). Isolation and sequence determination by means of two-
RT   dimensional NMR.";
RL   FEBS Lett. 256:91-96(1989).
CC   -!- FUNCTION: Labaditin is an active peptide which inhibits the classical
CC       pathway of complement activation in vitro. Activity seems to be based
CC       on an interaction with C1.
CC   -!- PTM: This is a cyclic peptide.
CC   -!- MISCELLANEOUS: Latex of this plant is used in folkloric medicine for
CC       treatment of infected wounds, skins infections and scabies.
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PE   1: Evidence at protein level;
KW   Direct protein sequencing.
FT   PEPTIDE         1..10
FT                   /note="Labaditin"
FT                   /id="PRO_0000044151"
FT   CROSSLNK        1..10
FT                   /note="Cyclopeptide (Ala-Ile)"
SQ   SEQUENCE   10 AA;  1089 MW;  D98AAD6362D1B362 CRC64;
     AGVWTVWGTI