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LAB_DROME
ID   LAB_DROME               Reviewed;         635 AA.
AC   P10105; O97065;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2002, sequence version 2.
DT   03-AUG-2022, entry version 200.
DE   RecName: Full=Homeotic protein labial;
DE   AltName: Full=F24;
DE   AltName: Full=F90-2;
GN   Name=lab; ORFNames=CG1264;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING, TISSUE
RP   SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   STRAIN=Oregon-R; TISSUE=Embryo;
RX   PubMed=2461299; DOI=10.1002/j.1460-2075.1988.tb03106.x;
RA   Mlodzik M., Fjose A., Gehring W.J.;
RT   "Molecular structure and spatial expression of a homeobox gene from the
RT   labial region of the Antennapedia-complex.";
RL   EMBO J. 7:2569-2578(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE (ISOFORM SHORT), AND CHARACTERIZATION.
RC   STRAIN=Canton-S, and Oregon-R; TISSUE=Embryo;
RX   PubMed=2566560; DOI=10.1101/gad.3.3.399;
RA   Diederich R.J., Merrill V.K.L., Pultz M.A., Kaufman T.C.;
RT   "Isolation, structure, and expression of labial, a homeotic gene of the
RT   Antennapedia Complex involved in Drosophila head development.";
RL   Genes Dev. 3:399-414(1989).
RN   [3]
RP   NUCLEOTIDE SEQUENCE (ISOFORM SHORT).
RC   STRAIN=Berkeley;
RA   Celniker S.E., Pfeiffer B., Knafels J., Martin C.H., Mayeda C.A.,
RA   Palazzolo M.J.;
RT   "Complete sequence of the Antennapedia complex of Drosophila.";
RL   Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM SHORT).
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [5]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
RC   STRAIN=Berkeley; TISSUE=Embryo;
RX   PubMed=10731138; DOI=10.1126/science.287.5461.2222;
RA   Rubin G.M., Hong L., Brokstein P., Evans-Holm M., Frise E., Stapleton M.,
RA   Harvey D.A.;
RT   "A Drosophila complementary DNA resource.";
RL   Science 287:2222-2224(2000).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 500-567, AND TISSUE SPECIFICITY.
RC   STRAIN=Canton-S;
RX   PubMed=3014511; DOI=10.1073/pnas.83.13.4809;
RA   Hoey T., Doyle H.J., Harding K., Wedeen C., Levine M.;
RT   "Homeo box gene expression in anterior and posterior regions of the
RT   Drosophila embryo.";
RL   Proc. Natl. Acad. Sci. U.S.A. 83:4809-4813(1986).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. Required for
CC       proper head development.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Long;
CC         IsoId=P10105-1; Sequence=Displayed;
CC       Name=Short;
CC         IsoId=P10105-2; Sequence=VSP_002397;
CC   -!- TISSUE SPECIFICITY: During embryogenesis, expressed in mandibular lobe,
CC       hypopharyngeal organ, neural and epidermal cells of procephalic lobe,
CC       sensory cells of clypeolabrum, posterior midgut, thoracic and abdominal
CC       segments. {ECO:0000269|PubMed:2461299, ECO:0000269|PubMed:3014511}.
CC   -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically. High
CC       expression in embryos and third instar larvae, lower expression in
CC       pupae. {ECO:0000269|PubMed:2461299}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. Labial subfamily.
CC       {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1, Met-2 or Met-7 is the
CC       initiator. {ECO:0000305}.
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DR   EMBL; X13103; CAA31495.1; -; mRNA.
DR   EMBL; X13104; CAB57786.1; -; Genomic_DNA.
DR   EMBL; X13105; CAB57786.1; JOINED; Genomic_DNA.
DR   EMBL; X13106; CAB57786.1; JOINED; Genomic_DNA.
DR   EMBL; X13104; CAB57787.1; -; Genomic_DNA.
DR   EMBL; X13105; CAB57787.1; JOINED; Genomic_DNA.
DR   EMBL; X13106; CAB57787.1; JOINED; Genomic_DNA.
DR   EMBL; AE001572; AAD19811.1; -; Genomic_DNA.
DR   EMBL; AE014297; AAF54098.1; -; Genomic_DNA.
DR   EMBL; AY095089; AAM11417.1; -; mRNA.
DR   EMBL; M13570; AAA28610.1; -; Genomic_DNA.
DR   PIR; A30168; A30168.
DR   PIR; S01164; S01164.
DR   RefSeq; NP_476613.1; NM_057265.4. [P10105-2]
DR   AlphaFoldDB; P10105; -.
DR   SMR; P10105; -.
DR   BioGRID; 66015; 11.
DR   DIP; DIP-59868N; -.
DR   IntAct; P10105; 2.
DR   STRING; 7227.FBpp0081194; -.
DR   PaxDb; P10105; -.
DR   DNASU; 40817; -.
DR   EnsemblMetazoa; FBtr0081696; FBpp0081194; FBgn0002522. [P10105-2]
DR   GeneID; 40817; -.
DR   KEGG; dme:Dmel_CG1264; -.
DR   UCSC; CG1264-RA; d. melanogaster. [P10105-1]
DR   CTD; 40817; -.
DR   FlyBase; FBgn0002522; lab.
DR   VEuPathDB; VectorBase:FBgn0002522; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   GeneTree; ENSGT00940000174017; -.
DR   HOGENOM; CLU_433673_0_0_1; -.
DR   InParanoid; P10105; -.
DR   OMA; WHHQQHL; -.
DR   SignaLink; P10105; -.
DR   BioGRID-ORCS; 40817; 0 hits in 3 CRISPR screens.
DR   GenomeRNAi; 40817; -.
DR   PRO; PR:P10105; -.
DR   Proteomes; UP000000803; Chromosome 3R.
DR   Bgee; FBgn0002522; Expressed in embryonic procephalic segment and 34 other tissues.
DR   ExpressionAtlas; P10105; baseline and differential.
DR   Genevisible; P10105; DM.
DR   GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR   GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IDA:FlyBase.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0046982; F:protein heterodimerization activity; IPI:FlyBase.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0007420; P:brain development; IMP:FlyBase.
DR   GO; GO:0035284; P:brain segmentation; IGI:FlyBase.
DR   GO; GO:0030154; P:cell differentiation; TAS:FlyBase.
DR   GO; GO:0001709; P:cell fate determination; TAS:FlyBase.
DR   GO; GO:0060323; P:head morphogenesis; IMP:FlyBase.
DR   GO; GO:0007494; P:midgut development; TAS:FlyBase.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:FlyBase.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR046327; HXA1/B1/D1.
DR   PANTHER; PTHR45946; PTHR45946; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Developmental protein; DNA-binding; Homeobox;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..635
FT                   /note="Homeotic protein labial"
FT                   /id="PRO_0000200262"
FT   DNA_BIND        507..566
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          39..113
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          127..153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          287..389
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          584..635
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        301..389
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        596..635
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         406..411
FT                   /note="Missing (in isoform Short)"
FT                   /evidence="ECO:0000303|PubMed:10731138"
FT                   /id="VSP_002397"
FT   CONFLICT        31
FT                   /note="S -> A (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        46
FT                   /note="P -> H (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        139
FT                   /note="T -> K (in Ref. 1; CAB57786/CAB57787)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        444
FT                   /note="G -> D (in Ref. 1; CAA31495/CAB57786/CAB57787)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        447
FT                   /note="N -> S (in Ref. 1 and 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   635 AA;  68154 MW;  B39A58813F4D5778 CRC64;
     MMDVSSMYGN HPHHHHPHAN AYDGYSTTTA SAANASSYFA PQQHQPHLQL QQQQQHQHLQ
     QPQQHLTYNG YESSSPGNYY PQQQAQLTPP PTSSHQVVQQ HQQQQQAQQQ QLYPHSHLFS
     PSAAEYGITT STTTGNPGTP LHPSSHSPAD SYYESDSVHS YYATAAVATV APPSNSSPIT
     AANASATSNT QQQQQQAAII SSENGMMYTN LDCMYPTAQA QAPVHGYAGQ IEEKYAAVLH
     ASYAPGMVLE DQDPMMQQAT QSQMWHHQQH LAGSYALDAM DSLGMHAHMH HGLPHGHLGN
     LANNPHQQQP QVQQQQQQPH QQPQHPQNQS PAAHQQHHQN SVSPNGGMNR QQRGGVISPG
     SSTSSSTSAS NGAHPASTQS KSPNHSSSIP TYKWMQLKRN VPKPQAPSYL PAPKLPASGI
     ASMHDYQMNG QLDMCRGGGG GGSGVGNGPV GVGGNGSPGI GGVLSVQNSL IMANSAAAAG
     SAHPNGMGVG LGSGSGLSSC SLSSNTNNSG RTNFTNKQLT ELEKEFHFNR YLTRARRIEI
     ANTLQLNETQ VKIWFQNRRM KQKKRVKEGL IPADILTQHS TSVISEKPPQ QQQPQPPELQ
     LKSQGSDLGG NELATGAPST PTTAMTLTAP TSKQS
 
 
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