ID   ARCC2_ENTFA             Reviewed;         312 AA.
AC   P59625;
DT   23-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   23-APR-2003, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Carbamate kinase 2;
DE            EC=2.7.2.2;
GN   Name=arcC2; Synonyms=arcC-2; OrderedLocusNames=EF_0386;
OS   Enterococcus faecalis (strain ATCC 700802 / V583).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=226185;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700802 / V583;
RX   PubMed=12663927; DOI=10.1126/science.1080613;
RA   Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R.,
RA   Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H.,
RA   Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C.,
RA   DeBoy R.T., Durkin S.A., Kolonay J.F., Madupu R., Nelson W.C.,
RA   Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M.,
RA   Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M.;
RT   "Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus
RT   faecalis.";
RL   Science 299:2071-2074(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + hydrogencarbonate + NH4(+) = ADP + carbamoyl phosphate +
CC         H(+) + H2O; Xref=Rhea:RHEA:10152, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58228, ChEBI:CHEBI:456216; EC=2.7.2.2;
CC   -!- PATHWAY: Metabolic intermediate metabolism; carbamoyl phosphate
CC       degradation; CO(2) and NH(3) from carbamoyl phosphate: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the carbamate kinase family. {ECO:0000305}.
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DR   EMBL; AE016830; AAO80247.1; -; Genomic_DNA.
DR   RefSeq; NP_814176.1; NC_004668.1.
DR   RefSeq; WP_002355252.1; NZ_KE136524.1.
DR   AlphaFoldDB; P59625; -.
DR   SMR; P59625; -.
DR   STRING; 226185.EF_0386; -.
DR   EnsemblBacteria; AAO80247; AAO80247; EF_0386.
DR   GeneID; 60892835; -.
DR   KEGG; efa:EF0386; -.
DR   PATRIC; fig|226185.45.peg.2943; -.
DR   eggNOG; COG0549; Bacteria.
DR   HOGENOM; CLU_076278_0_0_9; -.
DR   OMA; ESQGFIG; -.
DR   SABIO-RK; P59625; -.
DR   UniPathway; UPA00996; UER00366.
DR   Proteomes; UP000001415; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008804; F:carbamate kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006525; P:arginine metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0035975; P:carbamoyl phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd04235; AAK_CK; 1.
DR   Gene3D; 3.40.1160.10; -; 1.
DR   InterPro; IPR036393; AceGlu_kinase-like_sf.
DR   InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR   InterPro; IPR003964; Carb_kinase.
DR   PANTHER; PTHR30409; PTHR30409; 1.
DR   Pfam; PF00696; AA_kinase; 1.
DR   PIRSF; PIRSF000723; Carbamate_kin; 1.
DR   SUPFAM; SSF53633; SSF53633; 1.
DR   TIGRFAMs; TIGR00746; arcC; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism; ATP-binding; Cytoplasm; Kinase; Nucleotide-binding;
KW   Reference proteome; Transferase.
FT   CHAIN           1..312
FT                   /note="Carbamate kinase 2"
FT                   /id="PRO_0000185123"
SQ   SEQUENCE   312 AA;  33572 MW;  CCE2D334F33107F5 CRC64;
     MSLNVIALGG NAILDTDPTD EGQKAVVNHA AKYIAEFVAK GEQVIVCHGN GPQVGNLLLQ
     QKAGESEKNP ALKLDTCVAM TQGSIGYWLQ NALTNEFEKR NIAKPVISVV TQVRVDKEDP
     SFKKPSKPIG PFYTKEEADA EAAKDGSTYV EDAGRGYRKV VPSPMPKEIV EKEAVRALVE
     ADVLTICSGG GGIPVVAEDG QYVGVEAVND KDFSARVLAE NVDADRLIIL TGVDNIYINY
     NQPDQKALEQ ISVAEAEEYI KEGHFAAGSM LPKIEAALDF VKGDDKRKAI ITSIENLENI
     DKEAGTVISQ KG