LAC2_MOUSE
ID LAC2_MOUSE Reviewed; 104 AA.
AC P01844;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Ig lambda-2 chain C region;
GN Name=Iglc2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6812053; DOI=10.1073/pnas.79.15.4681;
RA Selsing E., Miller J., Wilson R., Storb U.;
RT "Evolution of mouse immunoglobulin lambda genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 79:4681-4685(1982).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6287422; DOI=10.1093/nar/10.13.3831;
RA Wu G.E., Govindji N., Hozumi N., Murialdo H.;
RT "Nucleotide sequence of a chromosomal rearranged lambda 2 immunoglobulin
RT gene of mouse.";
RL Nucleic Acids Res. 10:3831-3843(1982).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (MOPC 315).
RX PubMed=6283385; DOI=10.1038/298380a0;
RA Bothwell A.L.M., Paskind M., Reth M., Imanishi-Kari T., Rajewsky K.,
RA Baltimore D.;
RT "Somatic variants of murine immunoglobulin lambda light chains.";
RL Nature 298:380-382(1982).
RN [4]
RP PROTEIN SEQUENCE (MOPC 315).
RX PubMed=4760498;
RA Dugan E.S., Bradshaw R.A., Simms E.S., Eisen H.N.;
RT "Amino acid sequence of the light chain of a mouse myeloma protein (MOPC-
RT 315).";
RL Biochemistry 12:5400-5416(1973).
RN [5]
RP PROTEIN SEQUENCE OF 66-104 (MOPC 315), AND SEQUENCE REVISION.
RX PubMed=6165998; DOI=10.1073/pnas.78.1.569;
RA Azuma T., Steiner L.A., Eisen H.N.;
RT "Identification of a third type of lambda light chain in mouse
RT immunoglobulins.";
RL Proc. Natl. Acad. Sci. U.S.A. 78:569-573(1981).
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DR EMBL; J00595; AAA39151.1; -; Genomic_DNA.
DR PIR; C93922; L2MS.
DR PDB; 2QHR; X-ray; 2.00 A; L=1-102.
DR PDBsum; 2QHR; -.
DR AlphaFoldDB; P01844; -.
DR SMR; P01844; -.
DR STRING; 10090.ENSMUSP00000100464; -.
DR MaxQB; P01844; -.
DR PaxDb; P01844; -.
DR PeptideAtlas; P01844; -.
DR PRIDE; P01844; -.
DR ProteomicsDB; 264905; -.
DR Ensembl; ENSMUST00000103749; ENSMUSP00000100464; ENSMUSG00000076937.
DR MGI; MGI:99547; Iglc2.
DR VEuPathDB; HostDB:ENSMUSG00000076937; -.
DR eggNOG; ENOG502TFGA; Eukaryota.
DR GeneTree; ENSGT00940000153307; -.
DR InParanoid; P01844; -.
DR OMA; CQITHEG; -.
DR PhylomeDB; P01844; -.
DR EvolutionaryTrace; P01844; -.
DR PRO; PR:P01844; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; P01844; protein.
DR Bgee; ENSMUSG00000076937; Expressed in spleen and 58 other tissues.
DR ExpressionAtlas; P01844; baseline and differential.
DR Genevisible; P01844; MM.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR Pfam; PF07654; C1-set; 1.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Disulfide bond;
KW Immunoglobulin domain; Reference proteome.
FT CHAIN <1..104
FT /note="Ig lambda-2 chain C region"
FT /id="PRO_0000153609"
FT DOMAIN 6..99
FT /note="Ig-like"
FT DISULFID 27..85
FT DISULFID 103
FT /note="Interchain (with heavy chain)"
FT NON_TER 1
FT STRAND 7..11
FT /evidence="ECO:0007829|PDB:2QHR"
FT HELIX 15..19
FT /evidence="ECO:0007829|PDB:2QHR"
FT STRAND 22..35
FT /evidence="ECO:0007829|PDB:2QHR"
FT STRAND 38..43
FT /evidence="ECO:0007829|PDB:2QHR"
FT STRAND 46..48
FT /evidence="ECO:0007829|PDB:2QHR"
FT STRAND 52..54
FT /evidence="ECO:0007829|PDB:2QHR"
FT STRAND 58..60
FT /evidence="ECO:0007829|PDB:2QHR"
FT STRAND 63..73
FT /evidence="ECO:0007829|PDB:2QHR"
FT HELIX 74..79
FT /evidence="ECO:0007829|PDB:2QHR"
FT STRAND 83..89
FT /evidence="ECO:0007829|PDB:2QHR"
FT STRAND 92..98
FT /evidence="ECO:0007829|PDB:2QHR"
SQ SEQUENCE 104 AA; 11255 MW; CE4B67B8688862D3 CRC64;
QPKSTPTLTV FPPSSEELKE NKATLVCLIS NFSPSGVTVA WKANGTPITQ GVDTSNPTKE
GNKFMASSFL HLTSDQWRSH NSFTCQVTHE GDTVEKSLSP AECL
